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Article
Systemic and local immunity in juvenile autoimmune thyroiditis
The relative and absolute numbers of circulating and thyroidal T and B lymphocytes were studied in 16 euthyroid patients with juvenile autoimmune thyroiditis (JAIT). The same cell populations were tested for c...
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Article
A controlled study of the antihypertensive effect of carteolol, a newβ-adrenergic receptor blocking drug, in combination with hydrochlorthiazide and amiloride
The antihypertensive effect of carteolol, a new β-blocking agent, added to basal diuretic treatment (hydrochlorthiazide 50 mg and amiloride 5 mg) has been assessed in a controlled trial in 17 patients with mil...
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Article
Pharmacokinetics and tolerance of slow-release indomethacin tablets in rheumatoid arthritis
The pharmacokinetics, efficacy and tolerance of a new formulation of slow-release indomethacin tablet were compared with those of a conventional indomethacin capsule in 30 patients with rheumatoid arthritis. T...
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Article
Effect of acetylsalicylic acid on plasma thromboxane B2 and platelet aggregation in man
The effect of acetylsalicylic acid (ASA) on plasma thromboxane A2 (TXA2) and platelet aggregation was studied in 12 healthy, non-smoking, male students, in a double-blind, cross-over study, after single doses and...
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Article
Metabolic parameters after changing from hydrochlorothiazide to verapamil treatment in hypertension
The effect of verapamil on different metabolic parameters has been studied after changing the treatment of hypertension from hydrochlorothiazide to verapamil monotherapy. Verapamil 80 to 160 mg b.i.d. was cont...
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Article
Sustained release verapamil in hypertension. Results from a noninvasive ambulatory blood pressure monitoring and a clinical study
The antihypertensive effect of a new sustained-release matrix formulation of verapamil 200 mg was investigated in a dose-response study in patients with mild to moderate essential hypertension. Noninvasive amb...
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Article
Pharmacokinetics of slow-release diltiazem and its effect on atrioventricular conduction in healthy volunteers
The pharmacokinetics and effect of a slow-release and a conventional diltiazem tablet on atrioventricular conduction were compared in a randomized cross-over study after a single dose and at steady state in 12...
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Article
A six-month follow-up study of a slow-release indomethacin tablet in rheumatic diseases
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Article
Bilateral baker's cyst as the presenting symptom of paraneoplastic syndrome
Paraneoplastic syndrome is defined as a systemic malignancy producing prostaglandins or other substances that lead to various manifestations, syndromes or diseases. In the following report we present a case of...
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Article
Effect of erythromycin on the oro-caecal transit time in man
Erythromycins often cause gastrointestinal side-effects due to an increase in motility or to change in the intestinal bacterial flora. In order to evaluate the effect of erythromycin on gastrointestinal motili...
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Article
The circadian heart rate but not blood pressure profile is influenced by the timing of β-blocker administration in hypertensives
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Article
Inhibition of human erythrocyte and gastroduodenal catechol-O-methyltransferase activity by nitecapone
The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in hea...
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Article
The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition
We have studied resting and exercise haemodynamics and catecholamine disposition after catechol-O-methyl-transferase (COMT) inhibition with nitecapone 100 mg t. d. s. for 7 days in 15 healthy men (aged 21 to 2...
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Article
Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone
The inhibition of soluble catechol-O-methyltransferase (S-COMT) in red blood cells (RBCs) by entacapone, and the pharmacokinetics of entacapone after single oral (5–800 mg) and IV (25 mg) doses have been examined...
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Article
COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers
We studied the effects of entacapone, a novel inhibitor of the enzyme catechol-O-methyltransferase (COMT), on spontaneous and levodopa (LD) modulated secretion of growth hormone (GH) and prolactin (PRL) in 12 ...
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Article
Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: lack of interactions
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Article
Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition
Objective: Entacapone is a peripherally acting catechol O-methyltransferase (COMT) inhibitor used as an adjunct to each daily levodopa/dopa decarboxylase (DDC) inhibitor dose in the trea...
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Article
Clinical advantages of COMT inhibition with entacapone – a review
Two catechol-O-methyltransferase (COMT) inhibitors, entacapone and tolcapone, were developed during the 1990’s to be used as adjuncts to levodopa (LD) – dopa decarboxylase (DDC) inhibitors in the treatment of Par...
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Article
A Comparison of SnifProbe and SPME for Aroma Sampling
The popular solid phase micro extraction (SPME) device and method is compared with SnifProbe (Gordin and Amirav in J Chromatogr A 903:155–172, 2000) in their application for coffee aroma sampling for its analysis...
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Article
Correction: Effects of neurodevelopmental risk factors on brainstem maturation in premature infants
