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Article
Pharmacokinetics of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, in man
Objective: This study investigated the pharmacokinetics of the catechol-O-methyltransferase (COMT) inhibitor entacapone by giving simultaneously stable non-radioactive isotope 13C-entacapone int...
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Article
COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers
We studied the effects of entacapone, a novel inhibitor of the enzyme catechol-O-methyltransferase (COMT), on spontaneous and levodopa (LD) modulated secretion of growth hormone (GH) and prolactin (PRL) in 12 ...
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Article
Haemodynamic interactions of a new calcium sensitizing drug levosimendan and captopril
Objective: Levosimendan in a new inodilator drug that sensitises troponin C in heart muscle cells to calcium, thus improving contractility. In previous studies, a single 2 mg intravenous dose of levosimendan inc...