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Article
Open AccessINOVATYON/ ENGOT-ov5 study: Randomized phase III international study comparing trabectedin/pegylated liposomal doxorubicin (PLD) followed by platinum at progression vs carboplatin/PLD in patients with recurrent ovarian cancer progressing within 6-12 months after last platinum line
This trial investigated the hypothesis that the treatment with trabectedin/PLD (TP) to extend the platinum-free interval (TFIp) can improve overall survival (OS) in patients with recurrent ovarian cancer (OC).
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Article
Assessment of PARP protein expression in epithelial ovarian cancer by ELISA pharmacodynamic assay and immunohistochemistry
Targeting Poly (ADP-ribose) polymerase 1 (PARP-1) involved in base excision repair (BER) has been shown to be a clinically effective treatment strategy in epithelial ovarian cancer (EOC) defective in homologou...
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Article
Open AccessCA-125 can be part of the tumour evaluation criteria in ovarian cancer trials: experience of the GCIG CALYPSO trial
CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration i...
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Article
Open AccessSCOTROC 2B: feasibility of carboplatin followed by docetaxel or docetaxel–irinotecan as first-line therapy for ovarian cancer
The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive...
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Article
Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
Background: Quercetin is a flavonoid with a wide range of biological activities. It mainly occurs in plants as glycosides, such as rutin (quercetin rutinoside) in tea. Quercetin and rutin are us...
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Article
Mitotic index in the subrenal capsule assay as an indicator of the chemosensitivity of ovarian cancer
The subrenal capsule assay (SRCA) is used in clinical oncology to assess the sensitivity of individual malignant tumors to various anticancer agents and their combinations. Mitotic indices reflect cancer cell...
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Article
Transient incidental glucosuria in children
A consecutive series of 78 children with transient asymptomatic glucosuria was studied and followed up for up to 7.3 years. The age at presentation was 0.9–17.6 (median 4.6) years. One third of the patients ha...
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Article
Serum insulin profiles in consecutive children 2 years after the diagnosis of IDDM
We studied associations of 24-h serum insulin profiles with insulin dose, age, gender, haemoglobin A1c (HbA1c) and C-peptide values, as well as blood glucose profiles in 77 consecutive childrennine aged 2–4, 1...
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Article
Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children
Associations of infant feeding patterns and milk consumption with cow's milk protein antibody titres were studied in 697 newly-diagnosed diabetic children, 415 sibling-control children and 86 birth-date-and se...
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Article
Natural history of preclinical IDDM in high risk siblings
To learn more about the preclinical phase of IDDM we observed for a median period of 46.5 months (range 0.5–69 months) a group of 57 siblings positive for ICA and/or IAA when first screened within 6 months of ...
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Article
Regulation of coumarin 7-hydroxylation in man
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Article
Decline of mumps antibodies in Type 1 (insulin-dependent) diabetic children and a plateau in the rising incidence of Type 1 diabetes after introduction of the mumps-measles-rubella vaccine in Finland
A nationwide mumps-measles-rubella vaccination was introduced in 1982 in Finland to children aged 1.5 to 6 years and since then mumps has virtually disappeared in the country. We investigated whether this rapi...
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Article
HLA haplotypes in Type 1 (insulin-dependent) diabetes mellitus: molecular analysis of the HLA-DQ locus
In Caucasians the predisposition to Type 1 (insulin-dependent) diabetes mellitus has been shown to associate with HLA-DR3,DQw2 and DR4,DQw8 and with the presence of amino acids other than aspartic acid at posi...
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Article
Epidemiology of childhood diabetes mellitus in Finland — background of a nationwide study of Type 1 (insulin-dependent) diabetes mellitus
A nationwide study of childhood Type 1 (insulin-dependent) diabetes mellitus was established in 1986 in Finland, the country with the highest incidence of this disease worldwide. The aim of the project called ...
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Article
Cardiac tamponade due to ovarian carcinoma
We describe a patient with ovarian carcinoma who presented with cardiac tamponade with subsequently development of cardiac arrest as the initial symptom. After successful resuscitation and pericardiocentesis o...
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Article
Perforation of the uterus following IUD insertion in the puerperium
Perforation of the uterus by an IUD is very rare. However, during the puerperium when the uterus is small and the uterine wall is thin the risk of perforation increases. We present three patients treated withi...
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Article
Abdominopelvic actinomycosis associated with intrauterine devices. Two case reports
Two case reports of abdominopelvic actinomycosis associated with an intrauterine device (IUD) are presented. In the first case, the association was difficult to establish and in the second one, a pelvic malign...
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Article
LOW DOSE TESTOSTERONE TREATMENT OF DELAYED GROWTH
Anabolic steroids are used to accelerate the growth of normal boys with constitutional, delay of growth and puberty. We have treated 17 healthy boys aged 9.8 to 15.9 years (mean 13.3 years) who were short (hei...
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Article
JUVENILE AUTOIMMUNE THYROIDITIS (JAIT) IS ASSOCIATED WITH HLA-DR4
The associations of Hashimoto's goitrous thyroiditis with HLA-DR5, atrophic thyroiditis with DR3, postpartum thyroiditis with DR4 and Grave's disease with DR3 have been described. We studied HLA-A, B, C, DR an...
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Article
THYROID INFILTRATING CELLS III JUVENILE AUTOIMMUNE THYROIDITIS (JAIT)
Thyroid infiltrating cells in 12 patients with JAIT were analyzed. The mean age of the children was 13.6±1.7 years. Three of the patients were hypothyroid and two had elevated levels of TSH in serum. Eight had...
