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Article
Open AccessAppetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic suscep...
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Article
Open AccessCorrection: Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
A Correction to this paper has been published: https://doi.org/10.1038/s41366-021-00770-0
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Article
Open AccessGene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies
Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the fu...
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Article
Open AccessAssociations of sleep quality, quantity and nutrition in oldest-old men The Helsinki Businessmen Study (HBS)
To investigate associations of sleep quality and quantity and nutrition in oldest-old men.
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Article
Open AccessThe association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study
Approximately 25% of the general population carries at least one ε4 allele of the Apolipoprotein E (APOE ε4), the strongest genetic risk factor for late onset Alzheimer’s disease. Beyond its association with late...
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Article
Open AccessLong working hours and change in body weight: analysis of individual-participant data from 19 cohort studies
To examine the relation between long working hours and change in body mass index (BMI).
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Article
Open AccessRisk prediction models for dementia: role of age and cardiometabolic risk factors
Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is the only currently available midlife risk score for dementia. We compared CAIDE to Framingham cardiovascular Risk Score (FRS)...
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Article
Open AccessAssociations between long-term adherence to healthy diet and recurrent depressive symptoms in Whitehall II Study
We examined whether long-term adherence to three diet quality scores—the Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approach to Stop Hypertension (DASH) and transformed-Mediterranean Diet Scor...
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Article
Open AccessAssociation of moderate and vigorous physical activity with incidence of type 2 diabetes and subsequent mortality: 27 year follow-up of the Whitehall II study
This work examined the role of physical activity in the course of diabetes using data spanning nearly three decades. Our first aim was to examine the long-term association of moderate and vigorous physical act...
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Open AccessReversion from prediabetes to normoglycaemia and risk of cardiovascular disease and mortality: the Whitehall II cohort study
Reversion from prediabetes to normoglycaemia is accompanied by an improvement in cardiovascular risk factors, but it is unclear whether this translates into a reduction in risk of cardiovascular disease (CVD) ...
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Article
Open AccessDo worse baseline risk factors explain the association of healthy obesity with increased mortality risk? Whitehall II Study
To describe 20-year risk factor trajectories according to initial weight/health status and investigate the extent to which baseline differences explain greater mortality among metabolically healthy obese (MHO)...
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Article
Open AccessThe association between accelerometer-assessed physical activity and respiratory function in older adults differs between smokers and non-smokers
The association between physical activity and lung function is thought to depend on smoking history but most previous research uses self-reported measures of physical activity. This cross-sectional study inves...
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Article
Open AccessCorrection: Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies
This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly.
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Article
Open AccessHealthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies
With depression being the psychiatric disorder incurring the largest societal costs in developed countries, there is a need to gather evidence on the role of nutrition in depres...
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Article
Open AccessWork Stress and Satisfaction with Leadership Among Nurses Encountering Patient Aggression in Psychiatric Care: A Cross-Sectional Survey Study
We examined the associations between work stress (job strain, effort-reward imbalance), perceived job insecurity, workplace social capital, satisfaction with leadership and working hours in relation to the lik...
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Open AccessMulti-cohort study identifies social determinants of systemic inflammation over the life course
Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation...
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Article
Open AccessExploring variability in basal ganglia connectivity with functional MRI in healthy aging
Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving...
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Open AccessAuthor Correction: Development and validation of a risk prediction model for work disability: multicohort study
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessLong Working Hours and Risk of Cardiovascular Disease
To summarize the evidence on the relationship between long working hours and cardiovascular disease, such as coronary heart disease and stroke.
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Article
Open AccessEffect of retirement on cognitive function: the Whitehall II cohort study
According to the ‘use it or lose it’ hypothesis, a lack of mentally challenging activities might exacerbate the loss of cognitive function. On this basis, retirement has been suggested to increase the risk of ...
