-
Article
Open AccessDoes pattern mixture modelling reduce bias due to informative attrition compared to fitting a mixed effects model to the available cases or data imputed using multiple imputation?: a simulation study
Informative attrition occurs when the reason participants drop out from a study is associated with the study outcome. Analysing data with informative attrition can bias longitudinal study inferences. Approache...
-
Article
Open AccessAssociation of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies
Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk. We aimed to identify metabolite profiles associated with high adherence to dietary recommendations - the Alternat...
-
Article
Open AccessAllostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study
The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in ...
-
Article
Effects of stress on the development and progression of cardiovascular disease
Pooling of individual-level data and published data from multiple cohorts into mega-studies has allowed for a more precise assessment of the association betwee...
-
Article
Open AccessPsychosocial characteristics as potential predictors of suicide in adults: an overview of the evidence with new results from prospective cohort studies
In this narrative overview of the evidence linking psychosocial factors with future suicide risk, we collected results from published reports of prospective studies with verified suicide events (mortality or, ...
-
Article
Open AccessWorkplace bullying and violence as risk factors for type 2 diabetes: a multicohort study and meta-analysis
The aim of this multicohort study was to examine whether employees exposed to social stressors at work, such as workplace bullying and violence, have an increased risk of type 2 diabetes.
-
Article
Open AccessAdiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study
Biomarkers of inflammation and adiponectin are associated with cardiovascular autonomic neuropathy (CAN) in cross-sectional studies, but prospective data are scarce. This study aimed to assess the associations...
-
Article
Open AccessDevelopment and validation of a risk prediction model for work disability: multicohort study
Work disability affects quality of life, earnings, and opportunities to contribute to society. Work characteristics, lifestyle and sociodemographic factors have been associated with the risk of work disability...
-
Article
Open AccessWork stress, anthropometry, lung function, blood pressure, and blood-based biomarkers: a cross-sectional study of 43,593 French men and women
Work stress is a risk factor for cardio-metabolic diseases, but few large-scale studies have examined the clinical profile of individuals with work stress. To address this limitation, we conducted a cross-sect...
-
Article
Open AccessChange in body mass index during transition to statutory retirement: an occupational cohort study
Retirement is a major life transition affecting health behaviors. The aim of this study was to examine within-individual changes in body mass index (BMI) during transition from full-time work to statutory reti...
-
Article
Open AccessWork disability before and after a major cardiovascular event: a ten-year study using nationwide medical and insurance registers
We examined the trajectories of work disability before and after IHD and stroke events. New IHD (n = 13521) and stroke (n = 7162) cases in 2006–2008 were retrieved from nationwide Swedish hospital records and ...
-
Article
Open AccessLifecourse socioeconomic status and type 2 diabetes: the role of chronic inflammation in the English Longitudinal Study of Ageing
We examined the association between lifecourse socioeconomic status (SES) and the risk of type 2 diabetes at older ages, ascertaining the extent to which adult lifestyle factors and systemic inflammation expla...
-
Article
Open AccessChanges in physical activity during transition to retirement: a cohort study
Retirement is a major life transition which may affect lifestyle. The aim of this study is to examine within-individual changes in physical activity during the transition from full-time work to retirement.
-
Article
Open AccessLong working hours and cancer risk: a multi-cohort study
Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear.
-
Article
Clustering of adversity in young adults on disability pension due to mental disorders: a latent class analysis
Mental disorders are the leading cause of work disability among young adults. This study examined whether distinct classes could be identified among young adults on the basis of medical history before receivin...
-
Article
Trajectories of self-rated health in the last 15 years of life by cause of death
Poor self-rated health is associated with increased risk of mortality, but no previous study has examined how long-term trajectories of self-rated health differ among people at risk of subsequent death compare...
-
Chapter
Work Stress and Cardiovascular Disease: Reviewing Research Evidence with a Focus on Effort-Reward Imbalance at Work
Cardiovascular disease is the leading cause of death globally and a significant source of disability and impairment of quality of life. Stress may influence the development of cardiovascular disease across the...
-
Article
Open AccessIndependent and combined effects of physical activity and body mass index on the development of Type 2 Diabetes – a meta-analysis of 9 prospective cohort studies
The aim of this harmonized meta-analysis was to examine the independent and combined effects of physical activity and BMI on the incidence of type 2 diabetes.
-
Article
Open AccessWork Stress as a Risk Factor for Cardiovascular Disease
The role of psychosocial work stress as a risk factor for chronic disease has been the subject of considerable debate. Many researchers argue in support of a causal connection while others remain skeptical and...
-
Article
Open AccessAge trajectories of glycaemic traits in non-diabetic South Asian and white individuals: the Whitehall II cohort study
South Asian individuals have an increased prevalence of type 2 diabetes, but little is known about the development of glycaemic traits in this ethnic group. We compared age-related changes in glycaemic traits ...
