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Autonomic dysfunction is associated with the development of arterial stiffness: the Whitehall II cohort
This study aims to examine the association between baseline level and change of autonomic nervous function with subsequent development of arterial stiffness. Autonomic nervous function was assessed in 4901 pa...
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Open AccessMetformin use and early lactate levels in critically ill patients according to chronic and acute renal impairment
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Effect of familial diabetes status and age at diagnosis on type 2 diabetes risk: a nation-wide register-based study from Denmark
We assessed whether the risk of develo** type 2 diabetes and the age of onset varied with the age at diabetes diagnosis of affected family members.
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Open AccessReversion from prediabetes to normoglycaemia and risk of cardiovascular disease and mortality: the Whitehall II cohort study
Reversion from prediabetes to normoglycaemia is accompanied by an improvement in cardiovascular risk factors, but it is unclear whether this translates into a reduction in risk of cardiovascular disease (CVD) ...
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Effect of duration and burden of microvascular complications on mortality rate in type 1 diabetes: an observational clinical cohort study
The role of burden and duration of multiple microvascular complications on mortality rate has not been explored in detail in type 1 diabetes. Taking complication burden and time-updated duration into account w...
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Spousal cardiometabolic risk factors and incidence of type 2 diabetes: a prospective analysis from the English Longitudinal Study of Ageing
In the UK, more than one million people have undiagnosed diabetes and an additional five million are at high risk of develo** the disease. Given that early identification of these people is key for both prim...
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Article
Can insulin response patterns predict metabolic disease risk in individuals with normal glucose tolerance? Reply to Crofts CAP, Brookler K, Henderson G [letter]
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Glucose patterns during an oral glucose tolerance test and associations with future diabetes, cardiovascular disease and all-cause mortality rate
In addition to blood glucose concentrations measured in the fasting state and 2 h after an OGTT, intermediate measures during an OGTT may provide additional information regarding a person’s risk of future diab...
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Open AccessExamining the provisional guidelines for weight gain in twin pregnancies: a retrospective cohort study
Weight gain during pregnancy has an important impact on maternal and neonatal health. Unlike the Institute of Medicine (IOM) recommendations for weight gain in singleton pregnancies, those for twin gestations ...
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Open AccessTrajectories of glycaemia, insulin sensitivity and insulin secretion in South Asian and white individuals before diagnosis of type 2 diabetes: a longitudinal analysis from the Whitehall II cohort study
South Asian individuals have reduced insulin sensitivity and increased risk of type 2 diabetes compared with white individuals. Temporal changes in glycaemic traits during middle age suggest that impaired insu...
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Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk
We aimed to examine heterogeneity in glucose response curves during an oral glucose tolerance test with multiple measurements and to compare cardiometabolic risk profiles between identified glucose response cu...
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Open AccessAre women who quit smoking at high risk of excess weight gain throughout pregnancy?
Smoking cessation has been reported to be associated with high total gestational weight gain (GWG), which itself is a risk factor for adverse maternal-infant outcomes. Recent studies have criticized convention...
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Open AccessAge trajectories of glycaemic traits in non-diabetic South Asian and white individuals: the Whitehall II cohort study
South Asian individuals have an increased prevalence of type 2 diabetes, but little is known about the development of glycaemic traits in this ethnic group. We compared age-related changes in glycaemic traits ...
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The use of regression methods for the investigation of trends in suicide rates in Hungary between 1963 and 2011
Suicide rates in Hungary have been analyzed from different aspects in recent decades. However, only descriptive rates have been reported. The aim of our epidemiological study was to characterize the pattern of...