72 Result(s)

Article

H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition

The exit from pluripotency or pluripotent-somatic transition (PST) landmarks an event of early mammalian embryonic development, representing a model for cell fate transition.

Runxia Lin, Ziwei Zhai, Junqi Kuang, Chuman Wu, Yuxiang Yao, Ruona Shi… in Cell & Bioscience (2022)

Article

Akt-GSK3β-mPTP pathway regulates the mitochondrial dysfunction contributing to odontoblasts apoptosis induced by glucose oxidative stress

Diabetes Mellitus can cause dental pulp cells apoptosis by oxidative stress, and affect the integrity and function of dental pulp tissue. Mitochondria are the main attack targets of oxidative stress and have a...

Danni Wu, Liya Yan, Chuchu Zheng, Xuekun Ren, Yihuai Pan… in Cell Death Discovery (2022)

Article

Genetic correction of concurrent α- and β-thalassemia patient-derived pluripotent stem cells by the CRISPR-Cas9 technology

Thalassemia is a genetic blood disorder characterized by decreased hemoglobin production. Severe anemia can damage organs and severe threat to life safety. Allogeneic transplantation of bone marrow-derived hem...

Lingli Li, Hongyan Yi, Zheng Liu, ** Long, Tao Pan… in Stem Cell Research & Therapy (2022)

Article

Cancer-associated fibroblast-derived exosomal miR-18b promotes breast cancer invasion and metastasis by regulating TCEAL7

Studies have shown that cancer-associated fibroblasts (CAFs) play an irreplaceable role in the occurrence and development of tumors. Therefore, exploring the action and mechanism of CAFs on tumor cells is part...

Ziqian Yan, Zhimei Sheng, Yuanhang Zheng, Ruijun Feng, Qinpei **ao… in Cell Death & Disease (2021)

Article

CircRFX3 contributes to glioma progression through the circRFX3-miR-1179/miR-1229-VASP axis

Circular RNAs (circRNAs) are implicated in the carcinogenesis of human cancers. However, the functional roles of circRFX3 in glioma are not elucidated.

Hongli Li, Yiwei Zhang, Huiqin Song, Li Li in Cancer Cell International (2021)

Article

Genome sequencing and comparative genome analysis of 6 hypervirulent Klebsiella pneumoniae strains isolated in China

Hypervirulent Klebsiella pneumoniae (hvKP) has been increasingly reported over the past three decades and causes severe infections. To increase our understanding of hvKP at the genome level, genome sequencing and...

Ling Du, Jiaxue Zhang, Pin Liu, Xuan Li, Kewen Su, Lingyue Yuan… in Archives of Microbiology (2021)

Article

Utidelone inhibits growth of colorectal cancer cells through ROS/JNK signaling pathway

Utidelone (UTD1), a novel microtubule stabilizing agent, is an epothilone B analogue which was produced by genetic engineering. UTD1 has exhibited broad antitumor activity in multiple solid tumors. However, it...

Fuli Li, Tinglei Huang, Yao Tang, Qingli Li, Jianzheng Wang… in Cell Death & Disease (2021)

Article

Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis

Chuang Yuan, Ming Wu, Qicai **ao, Wang Zhao… in Signal Transduction and Targeted Therapy (2021)

Article

Radial extracorporeal shockwave promotes subchondral bone stem/progenitor cell self-renewal by activating YAP/TAZ and facilitates cartilage repair in vivo

Radial extracorporeal shockwave (r-ESW), an innovative and noninvasive technique, is gaining increasing attention in regenerative medicine due to its mechanobiological effects. Subchondral bone stem/progenitor...

Zhidong Zhao, Yuxing Wang, Qian Wang, Jiawu Liang, Wei Hu… in Stem Cell Research & Therapy (2021)

Article

Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by targeting HOXC6

Subretinal fibrosis resulting from neovascular age-related macular degeneration (nAMD) is one of the major causes of serious and irreversible vision loss worldwide, and no definite and effective treatment exis...

Dongli Li, Junxiu Zhang, Zijia Liu, Yuanyuan Gong… in Stem Cell Research & Therapy (2021)

Article

Linc00426 accelerates lung adenocarcinoma progression by regulating miR-455-5p as a molecular sponge

Increasing lines of evidence indicate the role of long non-coding RNAs (LncRNAs) in gene regulation and tumor development. Hence, it is important to elucidate the mechanisms of LncRNAs underlying the prolifera...

Hongli Li, Qingjie Mu, Guoxin Zhang, Zhixin Shen, Yuanyuan Zhang… in Cell Death & Disease (2020)

Article

Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE₂ and the associated epithelial barrier protein Filaggrin in the bronchial epithelium

Particulate matter (PM) is an environmental pollutant closely associated with human airway inflammation. However, the molecular mechanisms of PM-related airway inflammation remains to be fully elucidated. It i...

Chenjian Song, Ling**g Liu, Junjie Chen, Yiran Hu… in Cell Biology and Toxicology (2020)

Article

Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61

Circular RNAs (circRNAs) are emerging regulators in the development of human cancers. However, the role of circRNAs in melanoma is poorly understood. Microarray analysis and qRT-PCR was applied to screen out c...

Jun Chen, **aobo Zhou, Jie Yang, Qilin Sun, Yang Liu, Ningli Li… in Cell Death & Disease (2020)

Article

Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression

Tumor-necrosis factor (TNF) and its superfamily members are pleiotropic cytokines. Activation of TNF can lead to distinct cellular outcomes including inflammation, cell survival, and different forms of cell de...

Mingli Li, Shiyao Sun, Jessica Priest, **aolin Bi, Yun Fan in Cell Death & Disease (2019)

Article

RETRACTED ARTICLE: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in energy storage and metabolism regulation by the secreti...

Haiyang Zhang, Ting Deng, Shaohua Ge, Ying Liu, Ming Bai, Kegan Zhu, Qian Fan… in Oncogene (2019)