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Article
Open AccessCirc-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61
Circular RNAs (circRNAs) are emerging regulators in the development of human cancers. However, the role of circRNAs in melanoma is poorly understood. Microarray analysis and qRT-PCR was applied to screen out c...
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Article
Open AccessRetraction Note: Correlation of CD44v6 expression with ovarian cancer progression and recurrence
The authors have retracted this original article [1] because a number of the figures exhibit irregularities.
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Article
Open AccessCYR61, a potential biomarker of tumor inflammatory response in epithelial ovarian cancer microenvironment of tumor progress
Recent studies have found that inflammatory response is involved in the pathogenesis of ovarian cancer. Advanced ovarian cancer is often presented with ascites that is rich in cytokines, inflammatory factors o...
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Article
Open AccessFGF2 cooperates with IL-17 to promote autoimmune inflammation
IL-17 is a pro-inflammatory cytokine implicated a variety of autoimmune diseases. We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-...
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Article
Open AccessCCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis
CCN1, an extracellular protein also known as cysteine-rich protein 61 (Cyr61), is a novel pro-inflammatory factor involved in the pathogenesis of rheumatoid arthritis. As an inflammatory disease, psoriasis is ...
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Article
Open AccessCyr61 participates in the pathogenesis of acute lymphoblastic leukemia by enhancing cellular survival via the AKT/NF-κB signaling pathway
Cyr61 (CCN1) is the product of a growth factor–inducible immediate early gene and is involved in cell adhesion, survival, proliferation and differentiation. Cyr61 is overexpressed in human tumors and is involv...
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Article
Open AccessAdiponectin exacerbates collagen-induced arthritis via enhancing Th17 response and prompting RANKL expression
We previously reported adiponectin (AD) is highly expressed in the inflamed synovial joint tissue and correlates closely with progressive bone erosion in Rheumatoid arthritis (RA) patients. Here, we investigat...
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Article
Open AccessCyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis
It is well known that neutrophils play very important roles in the development of rheumatoid arthritis (RA) and interleukin (IL)-8 is a critical chemokine in promoting neutrophil migration. We previously showe...
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Article
Open AccessRETRACTED ARTICLE: Correlation of CD44v6 expression with ovarian cancer progression and recurrence
Previously some groups demonstrated that CD44 variant 6 (CD44v6) is correlated with progression and metastasis of ovarian cancer. However, a number of other groups failed to find such an association. Moreover,...
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Article
A novel anti-Cyr61 antibody inhibits breast cancer growth and metastasis in vivo
Cysteine-rich protein 61(CCN1/Cyr61) has been implicated as an important mediator in proliferation and metastasis of breast cancer, which indicated that blockage of Cyr61 might be a potent target for breast ca...
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Article
Apparent ages of suspended sediment and soil erosion of the Pearl River (Zhujiang) drainage basin
The carbon isotopic composition (Δ14C, δ13C) and apparent ages of suspended sediment were determined in the Pearl River in the years 1998, 2000 and 2005. These results indicate that suspended POC consists mostly ...
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Article
A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1
Bone-marrow-derived mesenchymal stem cells (MSCs) have been shown to possess immunosuppressive properties, e.g., by inhibiting T cell proliferation. Activated T cells can also enhance the immunosuppression abi...
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Article
Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells
Regulatory T cells (Treg) play important roles in immune system homeostasis, and may also be involved in tumor immunotolerance by suppressing Th1 immune response which is involved in anti-tumor immunity. We ha...
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Article
Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45β
Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reactions to deplete autoreactive T cells, which are involved in autoimmune diseases. However, it is unknown whether attenu...
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Article
The influence of the p53 gene on the in vitro chemosensitivity of colorectal cancer cells
Purpose : The p53 gene is considered one of the most important in the control of apoptosis, and its mutations have a close relationship with chemosensitivity. The aim of this work was to investigate the role of
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Article
Analysis of apoptosis by DNA end labeling method (TDT) in leukemia cell lines HL-60 and U937
Antitumor-drug-induced apoptosis in leukemia cell lines HL-60 and U937 was quantitatively analyzed with TDT (terminal deoxynuleotidyl transferase-mediated nick-end labeling) approach, which allows to label the...
