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Article
Open AccessStructural basis of peptide secretion for Quorum sensing by ComA
Quorum sensing (QS) is a crucial regulatory mechanism controlling bacterial signalling and holds promise for novel therapies against antimicrobial resistance. In Gram-positive bacteria, such as Streptococcus pneu...
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Article
Early detection of COPD based on graph convolutional network and small and weakly labeled data
Chronic obstructive pulmonary disease (COPD) is a common disease with high morbidity and mortality, where early detection benefits the population. However, the early diagnosis rate of COPD is low due to the ab...
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Article
Open AccessAkt-GSK3β-mPTP pathway regulates the mitochondrial dysfunction contributing to odontoblasts apoptosis induced by glucose oxidative stress
Diabetes Mellitus can cause dental pulp cells apoptosis by oxidative stress, and affect the integrity and function of dental pulp tissue. Mitochondria are the main attack targets of oxidative stress and have a...
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Article
Structure of a nascent membrane protein as it folds on the BAM complex
Mitochondria, chloroplasts and Gram-negative bacteria are encased in a double layer of membranes. The outer membrane contains proteins with a β-barrel structure1,2. β-Barrels are sheets of β-strands wrapped into ...
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Article
Spatial variability of soil organic matter in a gravel-sand mulched jujube orchard at field scale
In agricultural ecosystems, soil organic matter (SOM) is a major determinant and indicator of soil fertility and quality. The objectives of this study were to understand the spatial distribution of SOM and the...
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Article
Evaluation of Soil Fertility in a Gravel-Sand-Mulched Jujube (Ziziphus jujuba) Orchard Based on Modified Nemoro Fertility Indexing Method
An effective evaluation of soil fertility can provide a theoretical basis for managing quality and strategies of fertilization for soil. Based on 32 m × 32 m grid sampling, the soil organic matter, total N, to...
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Article
Comparison of IDW, cokriging and ARMA for predicting spatiotemporal variability of soil salinity in a gravel–sand mulched jujube orchard
Information about the spatiotemporal variability of soil salinity is important for managing salinization in gravel–sand mulched fields. We used inverse distance weighting (IDW) and cokriging to model the spati...
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Article
Develo** a comprehensive evaluation method for Interconnected River System Network assessment: A case study in Tangxun Lake group
The Interconnected River System Network (IRSN) plays a crucial role in water resource allocation, water ecological restoration and water quality improvement. It has become a key part of the urban lake manageme...
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Article
Open AccessStructural basis of RIP2 activation and signaling
Signals arising from bacterial infections are detected by pathogen recognition receptors (PRRs) and are transduced by specialized adapter proteins in mammalian cells. The Receptor-interacting-serine/threonine-...
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Article
Open AccessStructure of the mouse TRPC4 ion channel
Members of the transient receptor potential (TRP) ion channels conduct cations into cells. They mediate functions ranging from neuronally mediated hot and cold sensation to intracellular organellar and primary...
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Article
A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter
The cryo-electron microscopy structure of human TAP transporter, a peptide transporter central to MHC class I antigen presentation and cellular immunity, in complex with the herpes simplex virus protein ICP47.
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Article
Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel
Na+-activated K+ channels are members of the Slo family of large conductance K+ channels that are widely expressed in the brain, where their opening regulates neuronal excitability. These channels fulfil a number...
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Article
Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor
The active EGFR kinase domain dimerizes through an asymmetrical interface, and it is even more active when an asymmetric dimer is formed. Negative-stain EM analysis of EGFR now shows that the kinase domains of...
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Article
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization
Ribonucleotide reductase is essential to maintain the cellular pools of dNTPs, and its activity is controlled allosterically by ATP (activator) and dATP (inhibitor). Now crystal and EM structures of human and ...
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Article
Coat protein fold and maturation transition of bacteriophage P22 seen at subnanometer resolutions
Bacteriophage P22 is a prototypical biological machine used for studying protein complex assembly and capsid maturation. Using cryo-EM, we solved the structures of P22 before and after the capsid maturation at...
