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Potato Steroidal Glycoalkaloids: Biosynthesis and Genetic Manipulation

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Abstract

The potato steroidal glycoalkaloids (SGAs) are important components of plant resistance against pests and pathogens but can be toxic to humans at high levels. SGAs derive their toxicity from anticholinesterase activity affecting the central nervous system and the disruptive effects on cell membrane integrity affecting the digestive system and other organs. Accordingly, current safety regulations limit their content in the edible tuber to 20 mg per 100 g fresh weight. SGA composition and level are genetically determined, with unfavourable growth conditions and inappropriate postharvest management inducing the accumulation of SGAs at levels in the tubers of “safe” cultivars beyond the maximum level set by the industry. Hence, genetic alteration of potato to prevent toxic levels of SGAs in tubers is highly desirable. At the same time, maintaining high SGA levels in other plant organs will contribute to plant resistance against pathogen and pest attacks. To this end, SGA biosynthesis and degradation should be manipulated precisely to exploit tissue-specific expression rather than whole-plant suppression of SGA production, to produce potato cultivars with SGA content enriched in the foliage but diminished in the edible tubers. Only a few details are known about the SGA biosynthetic pathway, its genes and intermediates. Research on factors that regulate SGA biosynthesis and catabolism as well as searches for genetic markers linked to total and specific SGA levels have only recently been pursued. The present review summarizes current data on these issues to encourage further discussion on SGA manipulation for safer food products.

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Abbreviations

FPP:

2-trans,6-trans-Farnesyl diphosphate

HMGR:

3-hydroxy-3-methylglutaryl coenzyme A reductase

SGA:

steroidal glycoalkaloid

SS:

squalene synthase

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  1. Institute of Plant Sciences, ARO, Volcani Center, P.O. Box 6, Bet Dagan, 50250, Israel

    Idit Ginzberg

  2. Department of Horticulture, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA

    James G. Tokuhisa & Richard E. Veilleux

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  1. Idit Ginzberg
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Ginzberg, I., Tokuhisa, J.G. & Veilleux, R.E. Potato Steroidal Glycoalkaloids: Biosynthesis and Genetic Manipulation. Potato Res. 52, 1–15 (2009). https://doi.org/10.1007/s11540-008-9103-4

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