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Metformin protects retinal pigment epithelium cells against H2O2-induced oxidative stress and inflammation via the Nrf2 signaling cascade
PurposeDysfunctions of retinal pigment epithelium (RPE) attributed to oxidative stress and inflammation are implicated with age-related macular...
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Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells
The retinal pigment epithelium (RPE) is a polarized monolayer that secretes growth factors and cytokines towards the retina apically and the choroid...
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Biomechanical Characterization of Retinal Pigment Epitheliums Derived from hPSCs Using Atomic Force Microscopy
The retinal pigment epithelium (RPE), a multifunctional cell monolayer located at the back of the eye, plays a crucial role in the survival and...
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Low-dose rosmarinic acid and thymoquinone accelerate wound healing in retinal pigment epithelial cells
PurposeThymoquinone (TQ) and rosmarinic acid (RA) are two biologically active compounds found in plants and that possess remarkable anti-oxidant and...
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Transcriptional patterns of human retinal pigment epithelial cells under protracted high glucose
BackgroundThe retinal pigment epithelium (RPE) is essential for retinal homeostasis. Comprehensively exploring the transcriptional patterns of...
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Resveratrol and quercetin protect from Benzo(a)pyrene-induced autophagy in retinal pigment epithelial cells
PurposeThis study aims to investigate the role of Resveratrol (RES) and quercetin (QR) treatments against Benzo(a)pyrene (B(a)p)-induced autophagy in...
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Investigating mitochondrial fission, fusion, and autophagy in retinal pigment epithelium from donors with age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries, characterized by the death of retinal...
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Retinal and Choroidal Tumors
This chapter provides the vitreoretinal surgeon with a concise, practical, overview of important uveal tumors that is relevant to everyday...
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Comparison of pigment epithelium detachment composition indices between neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
PurposeTo compare changes in the fibrous component of pigment epithelium detachment composition indices (PEDCI-F) in neovascular age-related macular...
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Vitamin C alleviates hyperglycemic stress in retinal pigment epithelial cells
BackgroundRetinal pigment epithelial cells (RPECs) are a type of retinal cells that structurally and physiologically support photoreceptors. However,...
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Vitamin D alleviation of oxidative stress in human retinal pigment epithelial cells
BackgroundOxidative stress-induced retinal pigment epithelium (RPE) cell damage is a major factor in age-related macular degeneration (AMD). Vitamin D
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Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue
Mutations in the ubiquitously expressed pre-mRNA processing factor ( PRPF ) 31 gene, one of the most common causes of dominant form of Retinitis...
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In vivo multimodal retinal imaging of disease-related pigmentary changes in retinal pigment epithelium
Melanosomes, lipofuscin, and melanolipofuscin are the three principal types of pigmented granules found in retinal pigment epithelium (RPE) cells....
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Epithelial-Mesenchymal Transition: Molecular Mechanisms of Retinal Pigment Epithelial Cell Activation
AbstractActivated cells of human retinal pigment epithelium (RPE) are the main effector cells in the process of fibrosis, the main pathological...
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Human Wharton’s Jelly Mesenchymal Stem Cell Secretome Modifies the Processes of Neuroprotection and Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium at Transcriptional Level
BackgroundRetinal pigment epithelium (RPE) cells are potential targets for treating retinal detachment (RD) and proliferative vitreoretinopathy...
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En face optical coherence tomography transillumination for evaluation of retinal pigment epithelium alteration in central serous chorioretinopathy: correlation with multimodal imaging
PurposeTo study optical coherence tomography (OCT) en face imaging approach to evaluate retinal pigment epithelium (RPE) alteration in central serous...
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Oxidative stress in retinal pigment epithelium impairs stem cells: a vicious cycle in age-related macular degeneration
Aging, chronic oxidative stress, and inflammation are major pathogenic factors in the development and progression of age-related macular degeneration...
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An In Vitro Bilayer Model of Human Primary Retinal Pigment Epithelial and Choroid Endothelial Cells for Permeability Studies
The blood-retinal barrier (BRB) present in the posterior chamber of the eye plays a major role in maintaining the proper function and integrity of...
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Comparative Analysis of Physicochemical Characteristics of Fluorophore Groups of Lipofuscin Granules from Retinal Pigment Epithelium Cells of Human Cadaver Eyes in Normal and Pathology
AbstractA comparative study of individual groups of bisretinoids and their oxidation and degradation products in chloroform extracts from cells of...
