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Brivaracetam and topiramate serum levels during pregnancy and delivery: a case report and a review of literature
BackgroundAn increasing use of newer antiseizure medication (ASM) such as SV2A ligand brivaracetam is observed. However, data on newer antiseizure...
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Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy
Impairments in cognition are common in epilepsy and may be caused or exacerbated by antiseizure medications (ASMs). Positive effects on cognition may...
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Preferential Antiseizure Medications in Pediatric Patients with Convulsive Status Epilepticus: A Systematic Review and Network Meta-Analysis
Background and ObjectiveThe optimal choice for first- and second-line antiseizure medications for pediatric patients with convulsive status...
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Third-Generation Antiseizure Medications for Adjunctive Treatment of Focal-Onset Seizures in Adults: A Systematic Review and Network Meta-analysis
BackgroundBrivaracetam (BRV), cenobamate (CNB), eslicarbazepine acetate (ESL), lacosamide (LCM) and perampanel (PER) are antiseizure medications...
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Fenfluramine in clinical practice: new therapy option for Dravet and Lennox–Gastaut syndromes
Fenfluramine is an antiseizure medication for the treatment of Dravet and Lennox–Gastaut syndromes. This review summarizes the literature on the...
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The three pillars in treating antibody-mediated encephalitis
The rapid initiation of immunotherapy has a decisive impact on the course of the disease in patients with antibody-mediated encephalitis (AE). The...
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Genes Involved in Pharmacoresistant Epilepsy
This chapter is devoted to drug-resistant epilepsy and its genetic mechanisms. There are currently six hypotheses proposed for pharmacoresistant... -
Case report of antiseizure medicine-induced long QT syndrome and a literature review
BackgroundTo realize the clinical characteristics of long QT syndrome (LQTS) caused by antiseizure medicines (ASMs), and to improve the prevention...
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Antiseizure medications (antiepileptic drugs) in adults: starting, monitoring and stop**
Up to 10% of people living to 80 years of age have one or more seizures; and many will not require anti-seizure medication (ASMs). In 85% of...
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Non-adherence and epileptic emergency—reasons and solutions
BackgroundOne important cause of epileptic treatment failure and emergency department visits is due to non-adherence. Medication adherence is...
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Afebrile benign convulsions with or without a reversible splenial lesion in two pediatric patients with COVID-19
BackgroundSeizures in children with coronavirus disease 2019 (COVID-19) were markedly increased during the Omicron variant surge. Most seizures...
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Therapeutic Drug Monitoring of Lacosamide in Chinese Pediatric Patients with Epilepsy: Efficacy and Factors Influencing the Plasma Concentration
Background and ObjectiveThe impact of individual patient variables on drug metabolism is particularly important for antiseizure medication, and...
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Commentary: Consensus Guidelines on the Appropriate Use of Brand-Name and Generic Anti-Seizure Medication for the Management of Epilepsy in the Gulf Region
IntroductionThe clinical, social, and economic burden of epilepsy is undeniable. Local guidance on epilepsy management is limited and needed to...
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Effect of Number of Previous Antiseizure Medications on Efficacy and Tolerability of Adjunctive Brivaracetam for Uncontrolled Focal Seizures: Post Hoc Analysis
IntroductionThe aim was to evaluate the efficacy and tolerability of adjunctive brivaracetam (BRV) in adults with severely drug-resistant focal...
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Epilepsy and ASM Formulations
Epilepsy, characterized by abnormalities in neuronal activity, remains a challenge for a significant proportion of patients despite the increasing... -
Depression in Epilepsy
Depression is prevalent in people living with epilepsy (PLWE) due to a reciprocal relationship between both conditions. Various depressive disorders... -
The Current Role of Valproic Acid in the Treatment of Epilepsy: A Glimpse into the Present of an Old Ally
Purpose of the reviewThe primary purpose of this review is to explore the specific clinical scenarios where valproic acid demonstrates superiority...
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Treatment Outcomes of Newly Diagnosed Epilepsy: A Systematic Review and Meta-analysis
Background and ObjectivesUnderstanding the multi-faceted treatment outcomes of newly diagnosed epilepsy is critical for develo** rational...
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Variation in electroencephalography and neuroimaging for children receiving extracorporeal membrane oxygenation
BackgroundSeizures, strokes, and intracranial hemorrhage are common and feared complications in children receiving extracorporeal membrane...