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Satisfaction and tolerability using virtual reality (VR) as adjunctive treatment during flexible bronchoscopy: a randomized control trial
BackgroundPatient comfort during invasive and therapeutic procedures is important. The use of virtual reality (VR) devices during flexible...
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A randomized controlled double-blinded split-face prospective clinical trial to assess the efficacy, safety, and tolerability of a novel 3-step routine compared to benzoyl peroxide for the treatment of mild to moderate acne vulgaris
Adult acne vulgaris affects up to 43–51% of individuals. While there are numerous treatment options for acne including topical, oral, and...
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The utility and tolerability of ultrasound guided muscle biopsy in the investigation of myopathy: a follow-up study
IntroductionOpen surgical muscle biopsy has traditionally been required for the histological diagnosis of myopathy but requires neurosurgical...
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Interindividual differences in aronia juice tolerability linked to gut microbiome and metabolome changes—secondary analysis of a randomized placebo-controlled parallel intervention trial
BackgroundAronia melanocarpa is a berry rich in polyphenols known for health benefits. However, the bioavailability of polyphenols has been...
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Assessing tolerability and physiological responses to 17α-estradiol administration in male rhesus macaques
17α-estradiol has recently been shown to extend healthspan and lifespan in male mice through multiple mechanisms. These benefits occur in the absence...
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Efficacy and tolerability of lacosamide as adjunctive therapy in patients with focal-onset seizures: an observational, prospective study
PurposeTo evaluate the efficacy and tolerability of adjunctive lacosamide (LCM) in patients with focal-onset seizures, with or without combined...
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Safety, tolerability, pharmacokinetics and effects of diet on AD16, a novel neuroinflammatory inhibitor for Alzheimer’s disease: a randomized phase 1 study
BackgroundAD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing...
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Safety and Tolerability of Antimicrobial Agents in the Older Patient
Older patients are at high risk of infections, which often present atypically and are associated with high morbidity and mortality. Antimicrobial...
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First-in-Human Safety, Tolerability, and Pharmacokinetics of Single-Dose Kukoamine B Mesylate in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase I Study
IntroductionKukoamine B mesylate (KB) is a mesylate chrysamine B targeting lipopolysaccharides and CpG DNA, two potential treatment targets in sepsis.
...
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Efficacy, safety, and tolerability of dolutegravir-based ART regimen in Durban, South Africa: a cohort study
BackgroundDolutegravir is an integrase strand transfer inhibitor that has been recommended for use in first-line antiretroviral regimens by the World...
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Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
BackgroundWe compared the efficacy, tolerability, and safety of oral sulfate tablets (OST, which contains simethicone) and 2 L-polyethylene...
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Maximum dose, safety, tolerability and ketonemia after triheptanoin in glucose transporter type 1 deficiency (G1D)
Augmentation of anaplerosis, or replenishment of carbon lost during intermediary metabolic transitions, is desirable in energy metabolism defects....
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Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
BackgroundGalcanezumab has shown efficacy and effectiveness in the treatment of episodic and chronic migraine (CM), however, the population...
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Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies
Hedgehog pathway inhibitors (HHIs) have broadened the treatment options available for patients with advanced basal cell carcinoma (BCC) for whom...
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Comparing the tolerability of preservative-free tafluprost versus preserved latanoprost in the management of glaucoma and ocular hypertension — an observer blinded active-control trial
BackgroundDry eye is a condition related to long-term topical eye therapy. We wish to evaluate the effectiveness and tolerability of preservative...
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Tolerability of clobazam as add-on therapy in patients aged 50 years and older with drug-resistant epilepsy
ObjectiveTo evaluate the tolerability of clobazam in patients with drug-resistant epilepsy aged 50 years and older.
MethodsWe performed a single...
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Long-term safety, tolerability and efficacy of apomorphine sublingual film in patients with Parkinson’s disease complicated by OFF episodes: a phase 3, open-label study
BackgroundApomorphine sublingual film (SL-APO) is an on-demand treatment for OFF episodes in patients with Parkinson’s disease (PD).
Objective ...
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Pharmacokinetics and Tolerability of Zibotentan in Patients with Concurrent Moderate Renal and Moderate Hepatic Impairment
Background and ObjectiveZibotentan, a selective endothelin A receptor antagonist, is in development for chronic liver and kidney disease. The...
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Evaluating adherence, tolerability and safety of oral calcium citrate in elderly osteopenic subjects: a real-life non-interventional, prospective, multicenter study
BackgroundOsteoporosis is a common concern in the elderly that leads to fragile bones. Calcium supplementation plays a crucial role in improving bone...
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Long-Term Safety and Tolerability of Daridorexant in Patients with Insomnia Disorder
Background and ObjectiveDaridorexant is a dual orexin receptor antagonist for the treatment of insomnia. In two phase III, 12-week studies in...
