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An updated and comprehensive review of traditional uses, phytochemistry, and pharmacological progress on the Hypecoum genus
The Hypecoum genus belongs to the family Papaveraceae, consists of roughly 16 accepted species, and is extensively distributed from the Mediterranean...
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Niclosamide modulates phenotypic switch and inflammatory responses in human pulmonary arterial smooth muscle cells
Excessive proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) represent key steps of pulmonary vascular remodeling,...
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Evaluating the Impact of an Organic Trace Mineral mix on the Redox Homeostasis, Immunity, and Performance of Sows and their Offspring
The objective of the study was to evaluate the effects of trace mineral supplementation in sows during gestation and lactation on the performance and...
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KIAA1429 promotes the malignancy of oral squamous cell carcinoma by regulating CA9 m6A methylation
KIAA1429 has been reported as a cancer regulator, but its role and mechanism in the progression of oral squamous cell carcinoma (OSCC) remain...
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Delineation of the phenotypes and genotypes of PIK3CA-related overgrowth spectrum in East asians
PIK3CA -related overgrowth spectrum (PROS) is an umbrella term to describe a diverse range of developmental disorders. Research to date has...
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Carbene Complexes of Heme Proteins and Iron Porphyrin Models
The possible formation of carbene complexes of cytochromes P450 enzymes in various metabolisms of xenobiotics is first described. In view of these...
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Ferrocene–Peptide Bioconjugates
This chapter sketches an outline of ferrocene–peptide bioconjugates. A variety of ferrocene–peptide bioconjugates have been designed to induce...
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Catalytic Nickel–Iron–Sulfur Clusters: From Minerals to Enzymes
The geochemical theory of the origin of life proposes that primordial, pre-biotic reactions were carried out in a metal-sulfide-rich environment...
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Microwave-Assisted Synthesis and Functionalization of 2-Pyridones, 2-Quinolones and Other Ring-Fused 2-Pyridones
2-pyridones are important heterocycles with great applicability in medicinal chemistry and this core structure can be found in compounds with...
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Total Synthesis of Marine Macrolides
Recent progress (2002–2005) of total syntheses of bioactive marine macrolides, lasonolide A, zampanolide, dactylolide, and leucascandrolide A, was...
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Applications of Flexible Molecular Descriptors in the QSPR–QSAR Study of Heterocyclic Drugs
Various formulations of optimal descriptors introduced by different authors during the last 10 years are discussed for the special case of...
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QSAR and Molecular Modeling Studies of HIV Protease Inhibitors
Acquired immunodeficiency syndrome (AIDS) and its related disorders, caused by retrovirus human immunodeficiency virus (HIV) are a major health...
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Auxin Transport and Recycling of PIN Proteins in Plants
Polar transport of the phytohormone auxin is mediated by plasma-membrane and endosome localized carrier proteins. PIN proteins are the best...
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Microwave-Assisted Synthesis of Sulfur and Nitrogen-Containing Heterocycles
This chapter aims to review recent developments in the synthesis of sulfur and nitrogen-containing heteroaromatic compounds under conditions that...
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Spectroscopic Study of the Structure of Zetekitoxin AB
Zetekitoxin (former name: atelopidtoxin) was reported by Mosher and colleagues in 1969 as a potent, water-soluble, guanidinium toxin found in...
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The Chemistry of 2-(1H)-Pyrazinones in Solution and on Solid Support
An overview on the microwave-enhanced synthesis and decoration of the 2(1H)-pyrazinone system is presented. Scaffold decoration using...
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In silico Studies on PPARγ Agonistic Heterocyclic Systems
Several heterocyclic derivatives like oxazolidinediones, thiazolidinediones, tetarazoles, phenoxazines, etc. are being developed for the treatment...
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Manganese(III)-Based Peroxidation of Alkenes to Heterocycles
Synthesis of endoperoxides and hydroperoxides using tris(2,4-pentanedionato)manganese(III) or manganese(III) acetate is described. The reaction of...
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Rab GTPases in Plant Endocytosis
The Rab family is part of the Ras superfamily of small GTPases. In eukaryotes Rab GTPases are present as members of gene families, and the...
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MDR/PGP Auxin Transport Proteins and Endocytic Cycling
Auxin is an essential regulator of plant growth and development. Polarized transport of auxin is responsible for apical dominance, tropic growth,...