Abstract
2-pyridones are important heterocycles with great applicability in medicinal chemistry and this core structure can be found in compounds with various biological/medicinal applications. Here we show how microwave-assisted chemistry can be used to effectively synthesize and functionalize substituted monocyclic 2-pyridones, 2-quinolones and other ring-fused 2-pyridones. The chapter covers recent advancements in this field mainly describing methods developed with instruments specially designed for microwave-assisted organic synthesis (MAOS).
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Abbreviations
- BINAP:
-
2,2′-Bis(diphenylphosphino)-1,1′-binaphtyl
- BMS:
-
Borane methylsulfide
- Bn:
-
Benzyl
- Bu:
-
Butyl
- dba:
-
Dibenzylideneaceton
- DCE:
-
1,2-dichloroethane
- DEAD:
-
Diethyl azodicarboxylate
- DMA:
-
N,N-dimethylacetamide
- DME:
-
1,2-dimethoxyethane
- DMF:
-
N,N-dimethylformamide
- DMFDMA:
-
N,N-dimethylformamide dimethyl acetal
- DMFDEA:
-
N,N-dimethylformamide diethyl acetal
- MAOS:
-
Microwave-assisted organic synthesis
- MW:
-
Microwaves
- NBS:
-
N-bromosuccinimide
- NMP:
-
N-methyl-2-pyrrolidinone
- TEA:
-
Triethylamine
- TFA:
-
Trifluroacetic acid
- THF:
-
Tetrahydrofurane
- rt:
-
Room temperature
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Acknowledgments
We are very grateful to Prof. Dr. Basudeb Basu and M.Sc. Veronica Åberg for helpful discussions in the process of finalizing this book chapter.
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Pemberton, N., Chorell, E., Almqvist, F. Microwave-Assisted Synthesis and Functionalization of 2-Pyridones, 2-Quinolones and Other Ring-Fused 2-Pyridones. In: Van der Eycken, E., Kappe, C.O. (eds) Microwave-Assisted Synthesis of Heterocycles. Topics in Heterocyclic Chemistry, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_006
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