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Microwave-Assisted Synthesis of Sulfur and Nitrogen-Containing Heterocycles

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Microwave-Assisted Synthesis of Heterocycles

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 1))

Abstract

This chapter aims to review recent developments in the synthesis of sulfur and nitrogen-containing heteroaromatic compounds under conditions that include the application of microwave irradiation in the ring-forming step. The review is grouped according to the main heterocycle types in order of increasing complexity; commencing with five-membered sulfur-containing ring systems containing one, two, and three heteroatoms and their fused-ring analogues, followed by six- and seven-membered systems with more than one heteroatom, and then the analogous higher-membered ring systems. Fused-ring aromatic heterocycles and polycyclic molecules are also described.

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Abbreviations

Ac:

Acetyl

Ar:

Aryl

Bn:

Benzyl

Bu:

Butyl

t-Bu:

tert-butyl

Bz:

Benzoyl

DBU:

1,8-diazabicyclo[5.4.0]undec-7-ene

DCC:

N,N-dicyclohexylcarbodiimide

DCM:

Dichloromethane

DMAP:

4-(dimethylamino)pyridine

DMF:

Dimethylformamide

DMSO:

Dimethyl sulfoxide

Et:

Ethyl

Me:

Methyl

MW:

Microwave(s)

Ph:

Phenyl

Pr:

Propyl

i-Pr:

Isopropyl

TFA:

Trifluoroacetic acid

THF:

Tetrahydrofuran

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Authors and Affiliations

  1. Laboratoire de Biotechnologies et Chimie Bio-organique; FRE CNRS 2766, URF Sciences Fondamentales et Sciences pour l'Ingénieur, Université de La Rochelle, Batiment Marie Curie, 17042, La Rochelle cedex 1, France

    Thierry Besson & Valérie Thiéry

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  1. Thierry Besson
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  2. Valérie Thiéry
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Correspondence to Thierry Besson .

Editor information

Erik Van der Eycken C. Oliver Kappe

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Besson, T., Thiéry, V. Microwave-Assisted Synthesis of Sulfur and Nitrogen-Containing Heterocycles. In: Van der Eycken, E., Kappe, C.O. (eds) Microwave-Assisted Synthesis of Heterocycles. Topics in Heterocyclic Chemistry, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_008

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