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Ternary Solid Dispersion of Celecoxib Produced by the Solvent Method with Improved Solubility and Dissolution Properties
Celecoxib, the first cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug, has a wide range of pharmacological effects, including...
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Effects of Surfactant and Polymer on Thermodynamic Solubility and Solution Stability of Carbamazepine–Cinnamic Acid Cocrystal
This study was aimed at evaluating the solubility and solution stability of a cocrystal form of carbamazepine with cinnamic acid in the presence of...
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Determination of Paclitaxel Solubility and Stability in the Presence of Injectable Excipients
Due to poor aqueous solubility of paclitaxel, cremophor is one of the excipients used to improve solubility in Taxol while it is responsible for a...
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Development of New Dosage forms of Niclosamide with Increased Solubility and Cytotoxic Activity
The work was devoted to increasing the solubility of the anthelmintic agent niclosamide (NS). Methods for increasing the solubility of NS were...
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Enhancing solubility and bioavailability of coenzyme Q10: formulation of solid dispersions using Soluplus® as a carrier
Improving the aqueous solubility of poorly soluble compounds have been a major issue in the pharmaceutical industry. In the present study, binary...
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Influence of Water-Soluble Pharmaceutically Acceptable Polymers on the Solubility of Darunavir and Darunavir Ethanolate
The solubility of darunavir (D) and darunavir ethanolate (DE) at physiological pH values and temperatures in solutions of pharmaceutically acceptable...
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Strategies for Solubility Enhancement of Anthelmintics (Review)
Most drug substances are poorly soluble in water so that their efficacies must be improved by increasing the dosage, which not only creates economic...
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Studies on the Potential Vehicles (Co-Vehicles) for Formulating Intranasal Solution of Lamotrigine
Lamotrigine, an antiepileptic agent belonging to class II of the Biopharmaceutical Classification System (BCS), has linear pharmacokinetics and wide...
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Co-Amorphous System (Paracetamol:Indomethacin): Investigations on Physical Stability and Intermolecular Interactions
To increase the performance of indomethacin (IND) by enhancing its water solubility and promoting its therapeutic efficiency, a ternary physically...
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Physical Chemistry
Many pharmaceutical dosage forms are liquids or semi-liquids such as solutions, colloidal systems, suspensions and emulsions. This chapter deals with...
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New Formulation Technique for Solubility and Dissolution Rate Enhancement of Poorly Soluble Drugs
Ebastine (EBS) is a second-generation non-sedating antihistamine used for the prevention and treatment of allergic rhinitis and chronic idiopathic...
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Production of the Amorphous Form of Ibrutinib and Study of its Physicochemical Properties
The main lyophilization parameters enabling the production of amorphous ibrutinib active pharmaceutical ingredient (API) are presented. The amorphous...
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Determination of the Physical and Chemical Properties of Pomalidomide (Form A)
The structure and polymorphic modification of the active pharmaceutical ingredient (API) pomalidomide (AMEDART LLC, Russia), which appeared to be...
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Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids
The pharmacological activity of flavonoids as potential candidates for the development of drugs based on biologically active substances of plant...
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Design and Statistical Optimization of Pluronic Based Ibuprofen Gels by Box-Behnken Design and Their Physicochemical Characterization
The present work was focused on the development of pluronic based ibuprofen gels for the purpose of increasing drug solubility with the aid of...
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Water Soluble Curcuminoids: Encapsulation into Cyclodextrins and In-vitro Antioxidant Properties
A water-soluble curcuminoid powder was developed using cyclodextrins and quantified individual curcuminoids using high-performance liquid...
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Recent Formulation Advances of Mangiferin
Nutraceuticals have recently gained interest owing to their valuable contribution in the treatment of several diseases, with high safety margin and...
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Synthesis and In-Vitro Evaluation of Raloxifene–Oxalyl Chloride Conjugate Targeting Breast Cancer
Anticancer drugs mostly produce minimal to severe side effects due to lack of selectivity. The present work envisaged selective targeting of MCF-7...
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Nanocurcumin: its Applications in Preventive, Restorative, and Regenerative Dentistry
Curcumin, a natural biphenolicdiaryl heptanoid, is known to have a wide range of therapeutic dental applications due to its variety of biological and...
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Recent Advances in the Pharmacological Activities of Glycyrrhizin, Glycyrrhetinic Acid, and Their Analogs
In recent years, natural products have become increasingly popular for treating various ailments. Studies have shown that glycyrrhizin and...
