SpringerLink
Log in

Influence of Water-Soluble Pharmaceutically Acceptable Polymers on the Solubility of Darunavir and Darunavir Ethanolate

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

The solubility of darunavir (D) and darunavir ethanolate (DE) at physiological pH values and temperatures in solutions of pharmaceutically acceptable polymeric excipients was studied to substantiate dosage form formulations. Both substances were determined to dissolve better in HCl at pH 1.2 and 37°C. Use of PVP 90 in peroral dosage form formulations was shown to be unadvisable because of a negative effect on the solubility of the substances. The effect of Soluplus® on the solubility of D and DE was complicated by multifactor and heteropolar effects. PVP 12 – 30, HPMC 606, and Kollidon® VA64 HPC had positive effects on the solubility of D and DE substances. The best results were obtained for Eudragit® E PO solutions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. K. Goke, T. Lorenz, A. Repanas, et al., Eur. J. Pharm. Biopharm., No. 126, 40 – 56 (2018).

    Article  Google Scholar 

  2. J. C. R. Correa, D. M. D’Arcy, C. H. dos Reis Sierra, and H. R. N. Salgado, Pharmacology, 90, 102 – 103 (2012).

    Article  Google Scholar 

  3. S. A. Zolotov, N. B. Demina, and A. S. Zolotova, Vopr. Biol., Med. Farm. Khim., 22(6), 30 – 35 (2019).

    CAS  Google Scholar 

  4. N. B. Demina, Razrab. Regist. Lek. Sredstv, No. 2, 56 – 60 (2017).

    Google Scholar 

  5. J. Aguila-Hernandez, A. Trejo, and B. E. Garcia-Flores, J. Chem. Eng. Data, 56, 2371 – 2378 (2011).

    Article  CAS  Google Scholar 

  6. S. Mezdour, Food Hydrocolloids, 21, 776 – 781 (2007).

    Article  CAS  Google Scholar 

  7. Huanan Ligong Daxue Xuebao (J. South China Univ. Technol.), 41(12), 18 – 23 (2013).

  8. S. Tanida, T. Kurokawa, H. Sato, et al., Chem. Pharm. Bull., 64, 68 – 72 (2016).

    Article  Google Scholar 

  9. B. V. Reddy, G. Jyothi, B. S. Reddy, et al., J. Chromatogr. Sci., 51(5), 471 – 476 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. AMEDART LLC, Moscow, 109316, Russia

    S. A. Zolotov

  2. I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russia

    N. B. Demina

  3. Farm-Sintez Lab LLC, Moscow, 121205, Russia

    A. S. Zolotova

Authors
  1. S. A. Zolotov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. B. Demina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. S. Zolotova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. B. Demina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 12, pp. 44 – 47, December, 2020.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zolotov, S.A., Demina, N.B. & Zolotova, A.S. Influence of Water-Soluble Pharmaceutically Acceptable Polymers on the Solubility of Darunavir and Darunavir Ethanolate. Pharm Chem J 54, 1274–1277 (2021). https://doi.org/10.1007/s11094-021-02354-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-021-02354-8

Keywords

Search

Navigation