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Effects of Surfactant and Polymer on Thermodynamic Solubility and Solution Stability of Carbamazepine–Cinnamic Acid Cocrystal

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Pharmaceutical Chemistry Journal Aims and scope

This study was aimed at evaluating the solubility and solution stability of a cocrystal form of carbamazepine with cinnamic acid in the presence of sodium dodecyl sulfate (SDS) as surfactant and polyvinyl pyrrolidone K17 (PVP) as polymer in the aqueous medium. The solubilities of carbamazepine and cinnamic acid, as well as that of cocrystal, were evaluated in various media including phosphate buffer solution (PBS) (pH 6.8), SDS at 0.5 and 2% concentration, and PVP at 0.5, 1, and 2% concentration. Carbamazepine–cinnamic acid cocrystal was more soluble than carbamazepine alone in PBS. Solubility and solution stability of cocrystal were improved by PVP and SDS. At high SDS concentration (2%), solubility of cocrystal is less than carbamazepine because of preferential solubilization of the drug despite increase of solution stability. Thus, SDS and PVP significantly influence the solubility and solution stability of carbamazepine–cinnamic acid cocrystal, which should be taken into account in develo** cocrystal formulations.

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Authors and Affiliations

  1. Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Saba Sabouri

  2. Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Ali Shayanfar

  3. Editorial Office of Pharmaceutical Sciences Journal, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Ali Shayanfar

Authors
  1. Saba Sabouri
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  2. Ali Shayanfar
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Correspondence to Ali Shayanfar.

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Sabouri, S., Shayanfar, A. Effects of Surfactant and Polymer on Thermodynamic Solubility and Solution Stability of Carbamazepine–Cinnamic Acid Cocrystal. Pharm Chem J 56, 913–917 (2022). https://doi.org/10.1007/s11094-022-02726-8

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  • DOI: https://doi.org/10.1007/s11094-022-02726-8

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