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Hepatic drug-metabolizing enzymes and drug transporters in Wilson’s disease patients with liver failure
BackgroundWilson’s disease is a genetic disorder inherited in a recessive manner, caused by mutations in the copper-transporter ATP7B. Although it is...
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The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver
BackgroundOur recent studies showed that prolonged administration of novel atypical antipsychotics affected the expression and activity of cytochrome...
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The reference liver—CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype
BackgroundHepatic enzymes involved in drug metabolism vary markedly in expression, abundance and activity, which affects individual susceptibility to...
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Co-administration of Acarbose with Aqueous Extract of Root and Leaf of Sphenocentrum jollyanum Accelerates Wound Closure in Type 2 Diabetic Rats
Acarbose is an anti-hyperglycemic drug recognized as an inhibitor of carbohydrate-metabolizing enzymes. Hyperglycemia is a risk factor for wound...
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Synthetic cannabinoids are substrates and inhibitors of multiple drug-metabolizing enzymes
Synthetic cannabinoids, a new class of psychoactive substances, are potent agonists of cannabinoid receptors, which mimic the psychoactive effects of...
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GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders
Movement disorders are neurological conditions characterized by involuntary motor movements, such as dystonia, ataxia, chorea myoclonus, tremors,...
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Effects of simvastatin on nuclear receptors, drug metabolizing enzymes and transporters expression in Human Umbilical Vein Endothelial Cells
BackgroundVascular endothelial cells (EC) are constantly exposed to endo- and exogenous compounds, which may disturb EC function. One of the...
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Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review
Cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes involved in the biosynthesis and degradation of the...
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Investigation of the Anti-asthmatic Activity of Solidagenone, In Vitro Toxicity Versus In Silico Studies
Solidagenone, a labdane diterpene isolated from inflorescences of Solidago chilensis Meyen, Asteraceae, was investigated for its anti-inflammatory...
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Physiologically based pharmacokinetic modeling of candesartan related to CYP2C9 genetic polymorphism in adult and pediatric patients
Candesartan cilexetil is an angiotensin II receptor blocker and it is widely used to treat hypertension and heart failure. This drug is a prodrug...
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Tetrachloromethane Induced Acute Liver Injury in Mice: Biochemical and Histopathological Study of the Hepatoprotective Effect of Hep-X Standardized Botanical Dietary Supplement
This work was aimed at investigating the hepatoprotective effect of Hep-X, a polyherbal formulation containing Silybum marianum L. (Milk thistle), Rosm...
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Cannabinoids in the treatment of glioblastoma
Glioblastoma (GBM) is the most prevalent primary malignant tumor of the nervous system. While the treatment of other neoplasms is increasingly more...
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Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure–activity relationship, and prospects for clinical advancement
Cancer remains one of the leading causes of death in the world. Despite the considerable success of conventional treatment strategies, the incidence...
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Pharmacogenomics and Cancer Treatment
Somatic and germline genetic variations are two types of interindividual variations affecting drug response in cancer treatment. Pharmacogenomics...
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Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems
Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables. It was shown in numerous studies to be active against...
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Cis-element architecture of Nrf2–sMaf heterodimer binding sites and its relation to diseases
Cellular detoxication is essential for health because it provides protection against various chemicals and xenobiotics. The KEAP1–NRF2 system is...
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Pharmacology and adverse effects of new psychoactive substances: synthetic cannabinoid receptor agonists
Over the last decade, new psychoactive substances (NPS) have continuously been the focus of the international society since their emergence on the...
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Disease Prevention and Treatment Using β-Carotene: the Ultimate Provitamin A
Humans being unable to synthesize beta-carotene, the provitamin A, depend on external sources as its supplement. Health benefits and dietary...
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Assessment of Polyunsaturated Fatty Acids on COVID-19-Associated Risk Reduction
Pooled evidence conveys the association between polyunsaturated fatty acids and infectious disease. SARS-CoV-2, an enveloped mRNA virus, was also...
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Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
Pyrrolizidine alkaloids (PAs) are potent hepatotoxins that can cause liver damage. Hyperoside (Hyp), a natural flavonoid, can be extracted from...
