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Quercetin Simultaneously Inhibited Cytochrome P450 and P-Glycoprotein to Improve the Pharmacokinetics of Osthole in Rat Plasma
Plant-based medicines derived from traditional Chinese medicine have garnered widespread attention for their potential in the prevention and...
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Influence of Common Tansy (Tanacetum vulgare) Flower Polysaccharide Complex on P-Glycoprotein Transporter Activity in Vitro
The influence of the common tansy ( Tanacetum vulgare ) flower polysaccharide complex on P-glycoprotein (Pgp, ABCB1-protein) activity in Caco-2 cell...
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Computer Regression Models for P-Glycoprotein Transport of Drugs
Regression models of the cellular substrate specificity of 177 drugs for P-glycoprotein were built using linear regression, random forest, and...
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Cordycepin Inhibits Pathological High Shear-Induced Platelet Aggregation, Activation, and Phosphatidylserine Exposure by Regulating the Phosphorylation of Akt Protein
Cordycepin can effectively inhibit adenosine diphosphate-induced platelet aggregation; however, the inhibitory effect on shear-induced platelet...
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Prescribe colchicine with care and be aware of colchicine drug interactions
Colchicine has multiple anti-inflammatory properties and is used for a variety of disorders. As the use of colchicine expands from its approved uses...
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Pharmacological Strategies for Overcoming Multidrug Resistance to Chemotherapy
Actual mechanisms of multidrug resistance (MDR) to chemotherapy in oncology are considered. ABC-transporters such as P-glycoprotein, BCRP protein,...
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Synthesis, Pass Predication of Antimicrobial Activity and Pharmacokinetic Properties of Hexanoyl Galactopyranosides and Experimental Evaluation of their Action against Four Human Pathogenic Bacteria and Four Fungal Strains
Direct unimolar hexanoylation of methyl α-D-galactopyranoside (MDG) at low temperature gave 6- O -hexanoate in 53% yield indicating regioselectivity at...
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Experimental Studies of the Effects of Progesterone on the Functional Activity of P-Glycoprotein
Experiments on female Chinchilla rabbits addressed the effects of progesterone on the functional activity of P-glycoprotein (Pgp). Animals were...
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Gold Nanoparticles as Potential Antitumor Agents (Review)
The present review considers the main methods for obtaining nanoparticles of precious metals and methods of functionalization of their surfaces. The...
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Effects of Aspirin on the Bioavailability and Pharmacokinetics of Repaglinide: Possible Role of Cytochrome P450 3A Isoforms Inhibition by Aspirin
The purpose of this study was to investigate the effects of aspirin on the bioavailability and pharmacokinetics of repaglinide in rats. Repaglinide...
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Effects of Testosterone on the Functional Activity of P-Glycoprotein
The effects of testosterone undecanoate on the functional activity of P-glycoprotein (ABCB1 protein) were studied in male Chinchilla rabbits....
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Targeted Synthesis of New 5-Phenyl-2-[(E)-Styryl]-1H-Pyrimidin-6-One Derivatives and Their Inhibitory Activity Toward SARS-CoV-2 Major (MPRO) and Papain-Like Proteases (PLPRO)
The use of the 5-phenyl-1 H -pyrimidin-6-one scaffold in the search for biologically active compounds with antiviral activity based on the...
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ABCB1 c.2677G>T/c.3435C>T diplotype increases the early-phase oral absorption of losartan
Losartan has been shown to be a substrate of the drug-efflux transporter MDR1, encoded by the ABCB1 gene. ABCB1 c.2677G>T and c.3435C>T variants are...
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A Double-Edged Sword: Focusing on Potential Drug-to-Drug Interactions of Quercetin
Herbal and herbal dietary supplements have a massive share of the global market, and their use continues to grow worldwide. There is a general...
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Anti-dengue Potential of Mangiferin: Intricate Network of Dengue to Human Genes
Dengue fever has become one of the deadliest infectious diseases and requires the development of effective antiviral therapies. It is caused by...
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Adjust antimicrobial agent regimens in older patients to correct for changes in pharmacokinetics and to avoid adverse events
Treating infections with antimicrobial agents in older patients can be challenging. Physiological changes associated with aging can alter the...
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Wie wirken Arzneistoffe: Angriffspunkte für eine Therapie
Wie viele Angriffspunkte bestehen für eine Arzneimitteltherapie? Es gibt Abschätzungen, die von derzeit etwa 600–700 Zielstrukturen oder Targets...
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Liganden für Oberflächenrezeptoren
Im ► Kap. 29 wurden Rezeptoren vorgestellt, die eine Signalvermittlung von außerhalb einer Zelle in ihr...
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Paliperidone palmitate intramuscular 6-monthly formulation in schizophrenia: a profile of its use
The 6-monthly formulation of intramuscular paliperidone palmitate [INVEGA HAFYERA ™ (USA); BYANNLI ® (EU)] represents a useful and convenient...
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Current Advancements for New Drug Discovery Against Dengue Virus: A Review (2015 – 2020)
Dengue fever is a viral ailment mostly found in tropical and sub-tropical communities. Dengue fever is spread by the mosquito Aedes aegypti....
