Search
Search Results
-
Design, Synthesis, Biological Activity and Molecular Docking Studies of New Imine-Chalcone Derivatives
Schiff base derivatives, owing to their non-toxic qualities and biodegradability are widely used in the pharmaceutical-chemical industry,...
-
Investigation of Antimicrobial Activities and Molecular Docking Studies of Synthesized Sulfonamide Compounds
Sulfonamides are commonly used worldwide. In this study, several sulfonamide compounds such as N -(4-acetylphenyl)-4-methylbenzenesulfonamide (PSASF), N ...
-
The Anti-angiogenic and Anti-microbial Effect of Diosmin: Potential Receptor Interactions via Molecular Docking
This study examined the antiangiogenic capacity of diosmin in vitro and their interactions with certain important receptors related to cancer and...
-
Design, Synthesis, Pharmacological Screening and Molecular Docking Study of New Substituted Benzimidazole Derivatives
The present work aimed to study the therapeutic significance of various substituted benzimidazole derivatives in the treatment of peptic ulcers....
-
Integration of Antioxidant Activity, Affinity Ultrafiltration, and Molecular Docking Simulations to Decipher the Tyrosinase Inhibitor of Embelia laeta
Embelia laeta (L.) Mez., Primulaceae, is mostly used by Chinese ethnic minorities. However, only little is known about its antioxidant chemical...
-
Synthesis, Antiproliferative, and Molecular Docking Studies of 3-Mercapto-1,2,4-Triazole Derivatives as Combretastatin A-4 Analogs
In the present work, a series of 1,2,4-triazole derivatives are designed as combretastatin A-4 analogs with the 4-nitrophenyl group and different...
-
Ethionamide and Prothionamide Based Coumarinyl-Thiazole Derivatives: Synthesis, Antitubercular Activity, Toxicity Investigations and Molecular Docking Studies
The goal of this research work was to prepare and evaluate the antitubercular (anti-TB) activity of ethionamide (ETH) and prothionamide (PTH) based...
-
Deciphering the Antidiarrheal Mechanisms of Macleaya cordata by Combining Network Pharmacology, Molecular Docking, and Experimental Evaluations
Diarrhea continues to be a major public health problem and is thought to be the cause of 525,000 child fatalities annually. Studies have shown that Mac...
-
Synthesis, Anti-Inflammatory Activity and Molecular Docking Studies of New 1,2,4-Triazolo[3,4-b][1,3,4]Thiadiazine Derivatives
The reaction of 4-chlorobenzohydrazide 1 with carbon disulphide in the presence of methanolic potassium hydroxide afforded 4-chloro potassium...
-
The Cytotoxicity Profile, Apoptosis Mechanism, and Molecular Docking Studies of a Series of Benzimidazolium Derivative Morpholine-Substituted Ag(I) Heterocyclic Carbene Complexes
The main problems experienced in treatment with anticancer drugs are undesirable side effects, and toxicity. Minimal side effects for new anticancer...
-
Synthesis, Antioxidant and Some Enzyme Inhibition Activities of New Sulfonyl Hydrazones and their Molecular Docking Simulations
In this work, a series of new sulfonyl hydrazones were synthesized and screened for antioxidant and anticholinesterase, tyrosinase and urease enzyme...
-
α-Glucosidase Inhibitors from Marrubium astracanicum: Isolation and Molecular Docking
Marrubium astracanicum Jacq., Lamiaceae, is an herbaceous plant distributed in Iran, Turkey, and southern Caucasia. In the present study,...
-
Metabolomic Profiling and Cytotoxic Activity of Launaea nudicaulis: Molecular Docking with Topoisomerases
Launaea nudicaulis (L.) Hook. f., Asteraceae, is a wild plant growing in Egypt, used traditionally for treatment of many diseases. LC-HRMS analysis...
-
Chemical Constituents of Alocasia odora Rhizomes and Their Biological Activities: Experimental and Molecular Docking Approaches
Chemical research of the ethyl acetate extract from rhizomes of Alocasia odora (Roxb.) K.Koch, Araceae, led to the isolation and NMR determination of...
-
Synthesis, Molecular Docking and Biological Evaluation of Diaryl Pyrimidine Derivatives as Urease Inhibitors
Urease is a dinickel enzyme that is responsible for the hydrolysis of urea to ammonia and carbon dioxide. A series of bacteria like Helicobacter pylori ...
-
Synthesis, Antileishmanial Activity and Molecular Docking Study of New 3,4-Dihydropyrimidinones/Thiones
Appearance of drug-unresponsive strains of Leishmania genus and toxic side effects of current chemotherapies necessitate the search for novel...
-
Analysis of Artabotrys hexapetalus Stem Bark and Leaf Ethanol Extracts as α-Glucosidase Inhibitors: In Vitro Analysis, LC-MS/MS, Machine Learning, and Molecular Docking
Artabotrys hexapetalus (L.f.) Bhandari, Annonaceae, is one of Artabotrys species found in Asia, such as Sri Lanka, India, China, Malaysia, Indonesia,...
-
Synthesis, Antimalarial Activity Evaluation and Molecular Docking Studies of Some New Substituted Spiro-1,2,4,5-Tetraoxane Derivatives
Eight new substituted spiro-1,2,4,5-tetraoxane derivatives were synthesized and characterized by a number of analytical and spectroscopic techniques....
-
New Non-Carboxylic Acid Chalcones as Anti-Inflammatory Agents: Molecular Docking, Synthesis and Admet Studies
Chalcones in combination with heterocyclic moieties have been reported to exhibit diverse biological activities. The present study was aimed to...
-
Design, Synthesis and Molecular Docking of Vanillic Acid Derivatives as Amylolytic Enzyme Inhibitors
In the present work, a series of vanillic acid derivatives have been synthesized and tested to exhibit promising amylolytic enzymes inhibition....
