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1. Metabolic kinetic modeling of [¹¹C]methionine based on total-body PET in multiple myeloma

   Purpose

   Multiple myeloma (MM) is a malignant disease characterized by the secretion of monoclonal immunoglobulins and has a high demand for amino...

   Jia** Li, Beiwen Ni, ... Yumei Chen in European Journal of Nuclear Medicine and Molecular Imaging

   Article 11 April 2023
   

2. Feasibility of using abbreviated scan protocols with population-based input functions for accurate kinetic modeling of [¹⁸F]-FDG datasets from a long axial FOV PET scanner

   Background

   Accurate kinetic modeling of 18F-fluorodeoxyglucose ([ ¹⁸ F]-FDG) positron emission tomography (PET) data requires accurate knowledge of the...

   Hasan Sari, Lars Eriksson, ... Axel Rominger in European Journal of Nuclear Medicine and Molecular Imaging

   Article Open access 04 October 2022
   

3. Comparison of tracer kinetic models for ⁶⁸Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients

   Background

   ⁶⁸ Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional...

   Nathaniel J. Smith, Mark A. Green, ... Gary D. Hutchins in EJNMMI Research

   Article Open access 10 January 2024
   

4. Endometrial carcinoma: use of tracer kinetic modeling of dynamic contrast-enhanced MRI for preoperative risk assessment

   Background

   To compare two tracer kinetic models in predicting of preoperative risk types in endometrial carcinoma (EC) using DCE-MRI.

   Methods ...

   Zhijun Ye, Gang Ning, ... Haibo Qu in Cancer Imaging

   Article Open access 09 March 2022
   

5. DOCK–PET: database of CNS kinetic parameters in the healthy human brain for existing PET tracers

   Purpose

   Information about developed positron emission tomography (PET) tracers and obtained clinical PET images is publicly available in a database....

   Itsuki Miyajima, Ayano Yoshikawa, ... Miho Shidahara in Annals of Nuclear Medicine

   Article 30 May 2024
   

6. Drug characteristics derived from kinetic modeling: combined ¹¹C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A

   Background

   Antiepileptic drugs, levetiracetam (LEV) and brivaracetam (BRV), bind to synaptic vesicle glycoprotein 2A (SV2A). In their anti-seizure...

   Mika Naganawa, Jean-Dominique Gallezot, ... Richard E. Carson in EJNMMI Research

   Article Open access 08 November 2022
   

7. Population-based input function for TSPO quantification and kinetic modeling with [¹¹C]-DPA-713

   Introduction

   Quantitative positron emission tomography (PET) studies of neurodegenerative diseases typically require the measurement of arterial input...

   Mercy I. Akerele, Sara A. Zein, ... Sadek A. Nehmeh in EJNMMI Physics

   Article Open access 29 April 2021
   

8. Kinetic coupling in distal foot joints during walking

   Background

   Kinematic coupling between the first metatarsophalangeal (MTP) and midtarsal joints is evident during gait and other movement tasks,...

   Lauren R. Williams, Elisa S. Arch, Dustin A. Bruening in Journal of Foot and Ankle Research

   Article Open access 25 July 2023
   

9. Dynamic total-body PET/CT imaging with reduced acquisition time shows acceptable performance in quantification of [¹⁸F]FDG tumor kinetic metrics

   Purpose

   To investigate the feasibility of reducing the acquisition time for continuous dynamic positron emission tomography (PET) while retaining...

   Guobing Liu, Yimeng Shi, ... Hongcheng Shi in European Journal of Nuclear Medicine and Molecular Imaging

   Article 11 December 2023
   

10. Spatially constrained kinetic modeling with dual reference tissues improves ¹⁸F-flortaucipir PET in studies of Alzheimer disease

    Purpose

    Recent studies have shown that standard compartmental models using plasma input or the cerebellum reference tissue input are generally not...

    Yun Zhou, Shaney Flores, ... Tammie L. S. Benzinger in European Journal of Nuclear Medicine and Molecular Imaging

    Article 18 February 2021
    

11. Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain

    Purpose

    Translocator protein 18-kDa (TSPO) imaging with positron emission tomography (PET) is widely used in research studies of brain diseases that...

    Catriona Wimberley, Sonia Lavisse, ... Paolo Zanotti-Fregonara in European Journal of Nuclear Medicine and Molecular Imaging

    Article Open access 11 March 2021
    

12. Short-term PET-derived kinetic estimation for the diagnosis of hepatocellular carcinoma: a combination of the maximum-slope method and dual-input three-compartment model

    Background

    Kinetic estimation provides fitted parameters related to blood flow perfusion and fluorine-18-fluorodeoxyglucose ( ¹⁸ F-FDG) transport and...

    Tao Wang, Boqiao Li, ... Shaobo Wang in Insights into Imaging

    Article Open access 24 May 2023
    

13. Pharmacokinetics–Pharmacodynamics Modeling for Evaluating Drug–Drug Interactions in Polypharmacy: Development and Challenges

    Polypharmacy is commonly employed in clinical settings. The potential risks of drug–drug interactions (DDIs) can compromise efficacy and pose serious...

    Di Zhao, ** Huang, ... Yu He in Clinical Pharmacokinetics

    Article 18 June 2024
    

14. Application of physiologically based pharmacokinetics modeling in the research of small-molecule targeted anti-cancer drugs

    Introduction

    Physiologically based pharmacokinetics (PBPK) models are increasingly used in the drug research and development, especially in...

    **aowen Wang, Fang Chen, ... Bing Han in Cancer Chemotherapy and Pharmacology

    Article 19 July 2023
    

15. Mixing Matrix-corrected Whole-body Pharmacokinetic Modeling Using Longitudinal Micro-computed Tomography and Fluorescence-mediated Tomography

    Purpose

    Pharmacokinetic modeling can be applied to quantify the kinetics of fluorescently labeled compounds using longitudinal micro-computed...

    Simin Zuo, Wa’el Al Rawashdeh, ... Felix Gremse in Molecular Imaging and Biology

    Article Open access 06 July 2021
    

16. Dynamic chaotic gravitational search algorithm-based kinetic parameter estimation of hepatocellular carcinoma on ¹⁸F-FDG PET/CT

    Background

    Kinetic parameters estimated with dynamic ¹⁸ F-FDG PET/CT can help to characterize hepatocellular carcinoma (HCC). We aim to evaluate the...

    Jianfeng He, Tao Wang, ... Shaobo Wang in BMC Medical Imaging

    Article Open access 06 February 2022
    

17. Physiologically Based Pharmacokinetic Modeling to Simulate CYP3A4-Mediated Drug-Drug Interactions for Pyrotinib

    Introduction

    Pyrotinib is a newly developed tyrosine kinase inhibitor whose in vivo clearance relies heavily on cytochrome P450 3A4 (CYP3A4) activity....

    Liang Ni, Liang Zheng, ... ****g Chen in Advances in Therapy

    Article 16 July 2023
    

18. Combining deep learning with a kinetic model to predict dynamic PET images and generate parametric images

    Background

    Dynamic positron emission tomography (PET) images are useful in clinical practice because they can be used to calculate the metabolic...

    Ganglin Liang, **peng Zhou, ... Zhanli Hu in EJNMMI Physics

    Article Open access 24 October 2023
    

19. Cardiac amyloidosis characterization by kinetic model fitting on [18F]florbetaben PET images

    Objective

    To evaluate the feasibility of kinetic modeling-based approaches from [18F]-Flobetaben dynamic PET images as a non-invasive diagnostic...

    M. F. Santarelli, D. Genovesi, ... P. Marzullo in Journal of Nuclear Cardiology

    Article 16 April 2021
    

20. Kinetic Evaluation of the Hypoxia Radiotracers [¹⁸F]FMISO and [¹⁸F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging

    Purpose

    We evaluated the kinetics of the hypoxia PET radiotracers, [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluoroazomycin-arabinoside...

    Sangkyung Choen, Michael S. Kent, ... Allison L. Zwingenberger in Nuclear Medicine and Molecular Imaging

    Article Open access 11 October 2022