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1. Frontotemporal lobar degeneration

   Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset dementia and presents with early...

   Murray Grossman, William W. Seeley, ... John C. van Swieten in Nature Reviews Disease Primers

   Article 10 August 2023
   

2. Frontotemporal lobar degeneration in the “Annual of the Pathological Autopsy Cases in Japan”

   Background

   Good accuracy for the clinical diagnosis of frontotemporal lobar degeneration (FTLD) by specialists in an early onset dementia clinic has...

   Yoshihiko Horimoto, Chikako Sato, ... Hiroshi Inagaki in Journal of Neurology

   Article 22 June 2024
   

3. Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration

   Frontotemporal lobar degeneration (FTLD) is a common cause of young onset dementia and is characterised by focal neuropathology. The reasons for the...

   Yu Nie, Alexander Murley, ... Patrick F. Chinnery in Acta Neuropathologica

   Article Open access 30 April 2022
   

4. Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes

   Frontotemporal lobar degeneration (FTLD) is an umbrella term describing the neuropathology of a clinically, genetically and pathologically...

   Katherine Fodder, Megha Murthy, ... Conceição Bettencourt in Acta Neuropathologica

   Article Open access 07 May 2023
   

5. Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration

   Frontotemporal lobar degeneration with MAPT pathogenic variants (FTLD-MAPT) has heterogeneous tau pathological inclusions postmortem, consisting of...

   Lucia A. A. Giannini, Daniel T. Ohm, ... David J. Irwin in Acta Neuropathologica

   Article Open access 06 September 2022
   

6. The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration

   There is a pressing need to accelerate therapeutic strategies against the syndromes caused by frontotemporal lobar degeneration, including...

   Alistair Perry, Laura E. Hughes, ... James B. Rowe in Translational Psychiatry

   Article Open access 27 August 2022
   

7. Resting state functional brain networks associated with emotion processing in frontotemporal lobar degeneration

   This study investigated the relationship between emotion processing and resting-state functional connectivity (rs-FC) of the brain networks in...

   Elisa Canu, Davide Calderaro, ... Federica Agosta in Molecular Psychiatry

   Article Open access 20 May 2022
   

8. Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration

   Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of...

   Sidhartha Mahali, Rita Martinez, ... Celeste M. Karch in Translational Psychiatry

   Article Open access 10 December 2022
   

9. Frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43): its journey of more than 100 years

   Frontotemporal lobar degeneration (FTLD) with TDP-43-immunoreactive inclusions (FTLD–TDP) is a neurodegenerative disease associated with clinical,...

   Arenn F. Carlos, Keith A. Josephs in Journal of Neurology

   Article 23 March 2022
   

10. Elecsys Cerebrospinal Fluid Assays Accurately Distinguish Alzheimer’s Disease from Frontotemporal Lobar Degeneration

    Background

    Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) are heterogeneous in their clinical presentation and underlying...

    Marion Ortner, O. Goldhardt, ... T. Grimmer in The Journal of Prevention of Alzheimer's Disease

    Article Open access 04 March 2022
    

11. Measuring social cognition in frontotemporal lobar degeneration: a clinical approach

    Alterations in social cognition, a broad term indicating our ability to understand others and adapt our behavior accordingly, have been the focus of...

    Maria Antonietta Magno, Elisa Canu, ... Massimo Filippi in Journal of Neurology

    Article 19 November 2021
    

12. Signature laminar distributions of pathology in frontotemporal lobar degeneration

    Frontotemporal lobar degeneration (FTLD) with either tau (FTLD-tau) or TDP-43 (FTLD-TDP) inclusions are distinct proteinopathies that frequently...

    Daniel T. Ohm, Katheryn A. Q. Cousins, ... David J. Irwin in Acta Neuropathologica

    Article Open access 08 January 2022
    

13. TDP-43 pathology in the retina of patients with frontotemporal lobar degeneration

    Anke A. Dijkstra, Tjado H. J. Morrema, ... Jeroen J. M. Hoozemans in Acta Neuropathologica

    Article Open access 19 August 2023
    

14. Annexin A11 aggregation in FTLD–TDP type C and related neurodegenerative disease proteinopathies

    TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein found within ribonucleoprotein granules tethered to lysosomes via annexin A11. TDP-43...

    John L. Robinson, EunRan Suh, ... Edward B. Lee in Acta Neuropathologica

    Article Open access 19 June 2024
    

15. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches

    Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal neurodegenerative diseases and, to date, no validated diagnostic or...

    Nadine Huber, Sonja Korhonen, ... Annakaisa Haapasalo in Molecular Psychiatry

    Article Open access 19 November 2021
    

16. Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions

    Frontotemporal lobar degeneration (FTLD) is a group of heterogeneous neurodegenerative disorders affecting the frontal and temporal lobes of the...

    Rahat Hasan, Jack Humphrey, ... Towfique Raj in Acta Neuropathologica

    Article 28 December 2021
    

17. HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing

    Heterogeneous nuclear ribonucleoproteins (HnRNPs) are a group of ubiquitously expressed RNA-binding proteins implicated in the regulation of all...

    Alexander Bampton, Ariana Gatt, ... Tammaryn Lashley in Acta Neuropathologica

    Article Open access 18 July 2021
    

18. Neuroimaging-guided diagnosis of possible FTLD-FUS pathology: a case report

    Background

    This case report presents a patient with progressive memory loss and choreiform movements.

    Case presentation

    Neuropsychological tests...

    Gregory Mathoux, Cecilia Boccalini, ... Valentina Garibotto in EJNMMI Research

    Article Open access 04 April 2024
    

19. Awareness impairment in Alzheimer’s disease and frontotemporal dementia: a systematic MRI review

    This review aims to define awareness impairment and related disturbances in neurodegenerative diseases, including Alzheimer’s disease (AD) and...

    Michela Leocadi, Elisa Canu, ... Massimo Filippi in Journal of Neurology

    Article 13 December 2022
    

20. Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database

    TDP-43 proteinopathy is a salient neuropathologic feature in a subset of frontotemporal lobar degeneration (FTLD-TDP), in amyotrophic lateral...

    Davis C. Woodworth, Katelynn M. Nguyen, ... S. Ahmad Sajjadi in Acta Neuropathologica

    Article Open access 19 June 2024