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Measuring social cognition in frontotemporal lobar degeneration: a clinical approach

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Abstract

Alterations in social cognition, a broad term indicating our ability to understand others and adapt our behavior accordingly, have been the focus of growing attention in the past years. Some neurological conditions, such as those belonging to the frontotemporal lobar degeneration (FTLD) spectrum, are associated to varying degrees with social cognition deficits, encompassing problems with theory of mind (ToM), empathy, perception of social stimuli, and social behavior. In this review, we outline a clinical framework for the evaluation of social cognition and discuss its role in the assessment of patients affected by a range of FTLD conditions.

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Fig. 1
Fig. 2

Adapted from Shamay-Tsoory SG, Aharon-Peretz J (2007) Dissociable prefrontal networks for cognitive and affective theory of mind: a lesion study. Neuropsychologia 45 (13):3054–3067, with permission (b). Example stimuli of the RMET showing a serious man (top panel) and a reflective woman (bottom panel). Adapted from Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I (2001) The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 42 (2):241–251, with permission

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References

  1. Henry JD, von Hippel W, Molenberghs P, Lee T, Sachdev PS (2016) Clinical assessment of social cognitive function in neurological disorders. Nat Rev Neurol 12(1):28–39. https://doi.org/10.1038/nrneurol.2015.229

    Article  PubMed  Google Scholar 

  2. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134(Pt 9):2456–2477. https://doi.org/10.1093/brain/awr179

    Article  PubMed  PubMed Central  Google Scholar 

  3. Premack D, Woodruff G (1978) Does the chimpanzee have a theory of mind? Behav Brain Sci 1(4):515–526

    Article  Google Scholar 

  4. Fletcher PC, Happe F, Frith U, Baker SC, Dolan RJ, Frackowiak RS, Frith CD (1995) Other minds in the brain: a functional imaging study of “theory of mind” in story comprehension. Cognition 57(2):109–128. https://doi.org/10.1016/0010-0277(95)00692-r

    Article  CAS  PubMed  Google Scholar 

  5. Shamay-Tsoory SG, Harari H, Aharon-Peretz J, Levkovitz Y (2010) The role of the orbitofrontal cortex in affective theory of mind deficits in criminal offenders with psychopathic tendencies. Cortex 46(5):668–677. https://doi.org/10.1016/j.cortex.2009.04.008

    Article  PubMed  Google Scholar 

  6. Kalbe E, Schlegel M, Sack AT, Nowak DA, Dafotakis M, Bangard C, Brand M, Shamay-Tsoory S, Onur OA, Kessler J (2010) Dissociating cognitive from affective theory of mind: a TMS study. Cortex 46(6):769–780. https://doi.org/10.1016/j.cortex.2009.07.010

    Article  PubMed  Google Scholar 

  7. Sebastian CL, Fontaine NM, Bird G, Blakemore SJ, Brito SA, McCrory EJ, Viding E (2012) Neural processing associated with cognitive and affective theory of Mind in adolescents and adults. Soc Cogn Affect Neurosci 7(1):53–63. https://doi.org/10.1093/scan/nsr023

    Article  PubMed  Google Scholar 

  8. Baron-Cohen S, Leslie AM, Frith U (1985) Does the autistic child have a “theory of mind”? Cognition 21(1):37–46. https://doi.org/10.1016/0010-0277(85)90022-8

    Article  CAS  PubMed  Google Scholar 

  9. Wimmer H, Perner J (1983) Beliefs about beliefs: representation and constraining function of wrong beliefs in young children’s understanding of deception. Cognition 13(1):103–128. https://doi.org/10.1016/0010-0277(83)90004-5

    Article  CAS  PubMed  Google Scholar 

  10. McDonald S, Flanagan S, Rollins J, Kinch J (2003) TASIT: a new clinical tool for assessing social perception after traumatic brain injury. J Head Trauma Rehabil 18(3):219–238. https://doi.org/10.1097/00001199-200305000-00001

    Article  PubMed  Google Scholar 

  11. Stone VE, Baron-Cohen S, Knight RT (1998) Frontal lobe contributions to theory of mind. J Cogn Neurosci 10(5):640–656. https://doi.org/10.1162/089892998562942

    Article  CAS  PubMed  Google Scholar 

  12. Shamay-Tsoory SG, Aharon-Peretz J (2007) Dissociable prefrontal networks for cognitive and affective theory of mind: a lesion study. Neuropsychologia 45(13):3054–3067. https://doi.org/10.1016/j.neuropsychologia.2007.05.021

    Article  PubMed  Google Scholar 

  13. Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I (2001) The “Reading the Mind in the Eyes” Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 42(2):241–251

    Article  CAS  Google Scholar 

  14. Dodich A, Cerami C, Canessa N, Crespi C, Iannaccone S, Marcone A, Realmuto S, Lettieri G, Perani D, Cappa SF (2015) A novel task assessing intention and emotion attribution: Italian standardization and normative data of the Story-based Empathy Task. Neurol Sci 36(10):1907–1912. https://doi.org/10.1007/s10072-015-2281-3

    Article  PubMed  Google Scholar 

  15. Baron-Cohen S, Wheelwright S (2004) The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. J Autism Dev Disord 34(2):163–175. https://doi.org/10.1023/b:jadd.0000022607.19833.00

    Article  PubMed  Google Scholar 

  16. Davis MH (1983) Measuring individual differences in empathy: evidence for a multidimensional approach. J Pers Soc Psychol 44(1):113

    Article  Google Scholar 

  17. Dziobek I, Rogers K, Fleck S, Bahnemann M, Heekeren HR, Wolf OT, Convit A (2008) Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET). J Autism Dev Disord 38(3):464–473. https://doi.org/10.1007/s10803-007-0486-x

    Article  PubMed  Google Scholar 

  18. Benton AL (1994) Neuropsychological assessment. Annu Rev Psychol 45:1–23. https://doi.org/10.1146/annurev.ps.45.020194.000245

    Article  CAS  PubMed  Google Scholar 

  19. Duchaine B, Nakayama K (2006) The Cambridge Face Memory Test: results for neurologically intact individuals and an investigation of its validity using inverted face stimuli and prosopagnosic participants. Neuropsychologia 44(4):576–585. https://doi.org/10.1016/j.neuropsychologia.2005.07.001

    Article  PubMed  Google Scholar 

  20. Ekman P (1976) Pictures of facial affect. Consulting Psychologists Press

    Google Scholar 

  21. Froming K, Levy M, Schaffer S, Ekman P (2006) The comprehensive affect testing system. Psychology Software, Inc Available online at: http://www.psychologysoftware.com/CATS.htm

  22. de Gelder B, Van den Stock J (2011) The Bodily Expressive Action Stimulus Test (BEAST) construction and validation of a stimulus basis for measuring perception of whole body expression of emotions. Front Psychol 2:181. https://doi.org/10.3389/fpsyg.2011.00181

    Article  PubMed  PubMed Central  Google Scholar 

  23. Kennedy DP, Adolphs R (2012) The social brain in psychiatric and neurological disorders. Trends Cogn Sci 16(11):559–572. https://doi.org/10.1016/j.tics.2012.09.006

    Article  PubMed  PubMed Central  Google Scholar 

  24. Beer JS, John OP, Scabini D, Knight RT (2006) Orbitofrontal cortex and social behavior: integrating self-monitoring and emotion-cognition interactions. J Cogn Neurosci 18(6):871–879. https://doi.org/10.1162/jocn.2006.18.6.871

    Article  PubMed  Google Scholar 

  25. Fuster JM (2019) The prefrontal cortex in the neurology clinic. Handb Clin Neurol 163:3–15. https://doi.org/10.1016/B978-0-12-804281-6.00001-X

    Article  PubMed  Google Scholar 

  26. Moon Y, Moon WJ, Kim H, Han SH (2014) Regional atrophy of the insular cortex is associated with neuropsychiatric symptoms in Alzheimer’s disease patients. Eur Neurol 71(5–6):223–229. https://doi.org/10.1159/000356343

    Article  PubMed  Google Scholar 

  27. Moretti R, Signori R (2016) Neural correlates for apathy: frontal-prefrontal and parietal cortical-subcortical circuits. Front Aging Neurosci 8:289. https://doi.org/10.3389/fnagi.2016.00289

    Article  PubMed  PubMed Central  Google Scholar 

  28. Grace J (2001) Frontal systems behavior scale: professional manual. Psychological Assessment Resources

  29. Kertesz A, Nadkarni N, Davidson W, Thomas AW (2000) The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia. J Int Neuropsychol Soc 6(4):460–468. https://doi.org/10.1017/s1355617700644041

    Article  CAS  PubMed  Google Scholar 

  30. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 44(12):2308–2314. https://doi.org/10.1212/wnl.44.12.2308

    Article  CAS  PubMed  Google Scholar 

  31. Marin RS, Biedrzycki RC, Firinciogullari S (1991) Reliability and validity of the apathy evaluation scale. Psychiatry Res 38(2):143–162. https://doi.org/10.1016/0165-1781(91)90040-v

    Article  CAS  PubMed  Google Scholar 

  32. Magno MA, Canu E, Filippi M, Agosta F (2021) Social cognition in the FTLD spectrum: evidence from MRI. J Neurol. https://doi.org/10.1007/s00415-021-10892-0

    Article  PubMed  Google Scholar 

  33. Vogeley K (2017) Two social brains: neural mechanisms of intersubjectivity. Phil Trans R Soc B 372(1727):20160245

    Article  Google Scholar 

  34. Arioli M, Crespi C, Canessa N (2018) Social cognition through the lens of cognitive and clinical neuroscience. BioMed Res Int 2018:1–18

    Article  Google Scholar 

  35. Christidi F, Migliaccio R, Santamaría-García H, Santangelo G, Trojsi F (2018) Social cognition dysfunctions in neurodegenerative diseases: neuroanatomical correlates and clinical implications. Behav Neurol 2018:1–18

    Article  Google Scholar 

  36. Rabinovici GD, Miller BL (2010) Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs 24(5):375–398. https://doi.org/10.2165/11533100-000000000-00000

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Onyike CU, Diehl-Schmid J (2013) The epidemiology of frontotemporal dementia. Int Rev Psychiatry 25(2):130–137. https://doi.org/10.3109/09540261.2013.776523

    Article  PubMed  PubMed Central  Google Scholar 

  38. Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, Ogar JM, Rohrer JD, Black S, Boeve BF, Manes F, Dronkers NF, Vandenberghe R, Rascovsky K, Patterson K, Miller BL, Knopman DS, Hodges JR, Mesulam MM, Grossman M (2011) Classification of primary progressive aphasia and its variants. Neurology 76(11):1006–1014. https://doi.org/10.1212/WNL.0b013e31821103e6

    Article  PubMed  PubMed Central  Google Scholar 

  39. Bertoux M, O’Callaghan C, Dubois B, Hornberger M (2016) In two minds: executive functioning versus theory of mind in behavioural variant frontotemporal dementia. J Neurol Neurosurg Psychiatry 87(3):231–234. https://doi.org/10.1136/jnnp-2015-311643

    Article  PubMed  Google Scholar 

  40. Torralva T, Gleichgerrcht E, Torres Ardila MJ, Roca M, Manes FF (2015) Differential cognitive and affective theory of mind abilities at mild and moderate stages of behavioral variant frontotemporal dementia. Cogn Behav Neurol 28(2):63–70. https://doi.org/10.1097/WNN.0000000000000053

    Article  PubMed  Google Scholar 

  41. Dodich A, Crespi C, Santi GC, Luzzi S, Ranaldi V, Iannaccone S, Marcone A, Zamboni M, Cappa SF, Cerami C (2021) Diagnostic accuracy of affective social tasks in the clinical classification between the behavioral variant of frontotemporal dementia and other neurodegenerative disease. J Alzheimers Dis 80(4):1401–1411. https://doi.org/10.3233/JAD-201210

    Article  CAS  PubMed  Google Scholar 

  42. Adenzato M, Cavallo M, Enrici I (2010) Theory of mind ability in the behavioural variant of frontotemporal dementia: an analysis of the neural, cognitive, and social levels. Neuropsychologia 48(1):2–12. https://doi.org/10.1016/j.neuropsychologia.2009.08.001

    Article  PubMed  Google Scholar 

  43. Bora E, Walterfang M, Velakoulis D (2015) Theory of mind in behavioural-variant frontotemporal dementia and Alzheimer’s disease: a meta-analysis. J Neurol Neurosurg Psychiatry 86(7):714–719. https://doi.org/10.1136/jnnp-2014-309445

    Article  PubMed  Google Scholar 

  44. Schroeter ML, Pawelke S, Bisenius S, Kynast J, Schuemberg K, Polyakova M, Anderl-Straub S, Danek A, Fassbender K, Jahn H, Jessen F, Kornhuber J, Lauer M, Prudlo J, Schneider A, Uttner I, Thone-Otto A, Otto M, Diehl-Schmid J (2018) A modified reading the mind in the eyes test predicts behavioral variant frontotemporal dementia better than executive function tests. Front Aging Neurosci 10:11. https://doi.org/10.3389/fnagi.2018.00011

    Article  PubMed  PubMed Central  Google Scholar 

  45. Pardini M, Emberti Gialloreti L, Mascolo M, Benassi F, Abate L, Guida S, Viani E, Dal Monte O, Schintu S, Krueger F, Cocito L (2013) Isolated theory of mind deficits and risk for frontotemporal dementia: a longitudinal pilot study. J Neurol Neurosurg Psychiatry 84(7):818–821. https://doi.org/10.1136/jnnp-2012-303684

    Article  PubMed  Google Scholar 

  46. Delbeuck X, Pollet M, Pasquier F, Bombois S, Moroni C (2020) The clinical value of the faux pas test for diagnosing behavioral-variant frontotemporal dementia. J Geriatr Psychiatry Neurol. 891988720964253. https://doi.org/10.1177/0891988720964253

  47. Dodich A, Cerami C, Crespi C, Canessa N, Lettieri G, Iannaccone S, Marcone A, Cappa SF, Cacioppo JT (2016) Differential impairment of cognitive and affective mentalizing abilities in neurodegenerative dementias: evidence from behavioral variant of frontotemporal dementia, Alzheimer’s disease, and mild cognitive impairment. J Alzheimers Dis 50(4):1011–1022. https://doi.org/10.3233/JAD-150605

    Article  CAS  PubMed  Google Scholar 

  48. Gleichgerrcht E, Torralva T, Roca M, Pose M, Manes F (2011) The role of social cognition in moral judgment in frontotemporal dementia. Soc Neurosci 6(2):113–122. https://doi.org/10.1080/17470919.2010.506751

    Article  PubMed  Google Scholar 

  49. Gregory C, Lough S, Stone V, Erzinclioglu S, Martin L, Baron-Cohen S, Hodges JR (2002) Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer’s disease: theoretical and practical implications. Brain 125(Pt 4):752–764. https://doi.org/10.1093/brain/awf079

    Article  PubMed  Google Scholar 

  50. Narme P, Mouras H, Roussel M, Devendeville A, Godefroy O (2013) Assessment of socioemotional processes facilitates the distinction between frontotemporal lobar degeneration and Alzheimer’s disease. J Clin Exp Neuropsychol 35(7):728–744. https://doi.org/10.1080/13803395.2013.823911

    Article  PubMed  Google Scholar 

  51. Poletti M, Enrici I, Adenzato M (2012) Cognitive and affective Theory of Mind in neurodegenerative diseases: neuropsychological, neuroanatomical and neurochemical levels. Neurosci Biobehav Rev 36(9):2147–2164. https://doi.org/10.1016/j.neubiorev.2012.07.004

    Article  PubMed  Google Scholar 

  52. Snowden JS, Gibbons ZC, Blackshaw A, Doubleday E, Thompson J, Craufurd D, Foster J, Happe F, Neary D (2003) Social cognition in frontotemporal dementia and Huntington’s disease. Neuropsychologia 41(6):688–701. https://doi.org/10.1016/s0028-3932(02)00221-x

    Article  CAS  PubMed  Google Scholar 

  53. Henry JD, Phillips LH, von Hippel C (2014) A meta-analytic review of theory of mind difficulties in behavioural-variant frontotemporal dementia. Neuropsychologia 56:53–62. https://doi.org/10.1016/j.neuropsychologia.2013.12.024

    Article  PubMed  Google Scholar 

  54. Fernandez-Duque D, Baird JA, Black SE (2009) False-belief understanding in frontotemporal dementia and Alzheimer’s disease. J Clin Exp Neuropsychol 31(4):489–497. https://doi.org/10.1080/13803390802282688

    Article  PubMed  Google Scholar 

  55. Freedman M, Binns MA, Black SE, Murphy C, Stuss DT (2013) Theory of mind and recognition of facial emotion in dementia: challenge to current concepts. Alzheimer Dis Assoc Disord 27(1):56–61. https://doi.org/10.1097/WAD.0b013e31824ea5db

    Article  PubMed  Google Scholar 

  56. Kumfor F, Irish M, Leyton C, Miller L, Lah S, Devenney E, Hodges JR, Piguet O (2014) Tracking the progression of social cognition in neurodegenerative disorders. J Neurol Neurosurg Psychiatry 85(10):1076–1083. https://doi.org/10.1136/jnnp-2013-307098

    Article  PubMed  Google Scholar 

  57. Kipps CM, Nestor PJ, Acosta-Cabronero J, Arnold R, Hodges JR (2009) Understanding social dysfunction in the behavioural variant of frontotemporal dementia: the role of emotion and sarcasm processing. Brain 132(Pt 3):592–603. https://doi.org/10.1093/brain/awn314

    Article  CAS  PubMed  Google Scholar 

  58. Le Bouc R, Lenfant P, Delbeuck X, Ravasi L, Lebert F, Semah F, Pasquier F (2012) My belief or yours? Differential theory of mind deficits in frontotemporal dementia and Alzheimer’s disease. Brain 135(Pt 10):3026–3038. https://doi.org/10.1093/brain/aws237

    Article  PubMed  Google Scholar 

  59. Bertoux M, de Souza LC, O’Callaghan C, Greve A, Sarazin M, Dubois B, Hornberger M (2016) Social cognition deficits: the key to discriminate behavioral variant frontotemporal dementia from Alzheimer’s disease regardless of amnesia? J Alzheimers Dis 49(4):1065–1074. https://doi.org/10.3233/JAD-150686

    Article  PubMed  Google Scholar 

  60. Mariano LI, Caramelli P, Guimaraes HC, Gambogi LB, Moura MVB, Yassuda MS, Teixeira AL, de Souza LC (2020) Can social cognition measurements differentiate behavioral variant frontotemporal dementia from Alzheimer’s disease regardless of Apathy? J Alzheimers Dis 74(3):817–827. https://doi.org/10.3233/JAD-190861

    Article  PubMed  Google Scholar 

  61. Lough S, Gregory C, Hodges JR (2001) Dissociation of social cognition and executive function in frontal variant frontotemporal dementia. Neurocase 7(2):123–130. https://doi.org/10.1093/neucas/7.2.123

    Article  CAS  PubMed  Google Scholar 

  62. Lough S, Kipps CM, Treise C, Watson P, Blair JR, Hodges JR (2006) Social reasoning, emotion and empathy in frontotemporal dementia. Neuropsychologia 44(6):950–958. https://doi.org/10.1016/j.neuropsychologia.2005.08.009

    Article  PubMed  Google Scholar 

  63. Torralva T, Kipps CM, Hodges JR, Clark L, Bekinschtein T, Roca M, Calcagno ML, Manes F (2007) The relationship between affective decision-making and theory of mind in the frontal variant of fronto-temporal dementia. Neuropsychologia 45(2):342–349. https://doi.org/10.1016/j.neuropsychologia.2006.05.031

    Article  PubMed  Google Scholar 

  64. Carr AR, Mendez MF (2018) Affective empathy in behavioral variant frontotemporal dementia: a meta-analysis. Front Neurol 9:417. https://doi.org/10.3389/fneur.2018.00417

    Article  PubMed  PubMed Central  Google Scholar 

  65. Dermody N, Wong S, Ahmed R, Piguet O, Hodges JR, Irish M (2016) Uncovering the neural bases of cognitive and affective empathy deficits in Alzheimer’s disease and the behavioral-variant of frontotemporal dementia. J Alzheimers Dis 53(3):801–816. https://doi.org/10.3233/JAD-160175

    Article  PubMed  Google Scholar 

  66. Eslinger PJ, Moore P, Anderson C, Grossman M (2011) Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia. J Neuropsychiatry Clin Neurosci 23(1):74–82. https://doi.org/10.1176/appi.neuropsych.23.1.74

    Article  PubMed  PubMed Central  Google Scholar 

  67. 1176/jnp.23.1.jnp74

  68. Hsieh S, Irish M, Daveson N, Hodges JR, Piguet O (2013) When one loses empathy: its effect on carers of patients with dementia. J Geriatr Psychiatry Neurol 26(3):174–184. https://doi.org/10.1177/0891988713495448

    Article  PubMed  Google Scholar 

  69. Oliver LD, Mitchell DG, Dziobek I, MacKinley J, Coleman K, Rankin KP, Finger EC (2015) Parsing cognitive and emotional empathy deficits for negative and positive stimuli in frontotemporal dementia. Neuropsychologia 67:14–26. https://doi.org/10.1016/j.neuropsychologia.2014.11.022

    Article  PubMed  Google Scholar 

  70. Baez S, Manes F, Huepe D, Torralva T, Fiorentino N, Richter F, Huepe-Artigas D, Ferrari J, Montanes P, Reyes P, Matallana D, Vigliecca NS, Decety J, Ibanez A (2014) Primary empathy deficits in frontotemporal dementia. Front Aging Neurosci 6:262. https://doi.org/10.3389/fnagi.2014.00262

    Article  PubMed  PubMed Central  Google Scholar 

  71. Takeda A, Sturm VE, Rankin KP, Ketelle R, Miller BL, Perry DC (2019) Relationship turmoil and emotional empathy in frontotemporal dementia. Alzheimer Dis Assoc Disord 33(3):260–265. https://doi.org/10.1097/WAD.0000000000000317

    Article  PubMed  PubMed Central  Google Scholar 

  72. Kumfor F, Piguet O (2012) Disturbance of emotion processing in frontotemporal dementia: a synthesis of cognitive and neuroimaging findings. Neuropsychol Rev 22(3):280–297. https://doi.org/10.1007/s11065-012-9201-6

    Article  PubMed  Google Scholar 

  73. Bora E, Velakoulis D, Walterfang M (2016) Meta-analysis of facial emotion recognition in behavioral variant frontotemporal dementia: comparison with Alzheimer disease and healthy controls. J Geriatr Psychiatry Neurol 29(4):205–211. https://doi.org/10.1177/0891988716640375

    Article  PubMed  Google Scholar 

  74. Fernandez-Duque D, Black SE (2005) Impaired recognition of negative facial emotions in patients with frontotemporal dementia. Neuropsychologia 43(11):1673–1687. https://doi.org/10.1016/j.neuropsychologia.2005.01.005

    Article  PubMed  Google Scholar 

  75. Jastorff J, De Winter FL, Van den Stock J, Vandenberghe R, Giese MA, Vandenbulcke M (2016) Functional dissociation between anterior temporal lobe and inferior frontal gyrus in the processing of dynamic body expressions: Insights from behavioral variant frontotemporal dementia. Hum Brain Mapp 37(12):4472–4486. https://doi.org/10.1002/hbm.23322

    Article  PubMed  PubMed Central  Google Scholar 

  76. Van den Stock J, De Winter FL, de Gelder B, Rangarajan JR, Cypers G, Maes F, Sunaert S, Goffin K, Vandenberghe R, Vandenbulcke M (2015) Impaired recognition of body expressions in the behavioral variant of frontotemporal dementia. Neuropsychologia 75:496–504. https://doi.org/10.1016/j.neuropsychologia.2015.06.035

    Article  PubMed  Google Scholar 

  77. Downey LE, Blezat A, Nicholas J, Omar R, Golden HL, Mahoney CJ, Crutch SJ, Warren JD (2013) Mentalising music in frontotemporal dementia. Cortex 49(7):1844–1855. https://doi.org/10.1016/j.cortex.2012.09.011

    Article  PubMed  PubMed Central  Google Scholar 

  78. Hsieh S, Hornberger M, Piguet O, Hodges JR (2012) Brain correlates of musical and facial emotion recognition: evidence from the dementias. Neuropsychologia 50(8):1814–1822. https://doi.org/10.1016/j.neuropsychologia.2012.04.006

    Article  CAS  PubMed  Google Scholar 

  79. Russell LL, Greaves CV, Bocchetta M, Nicholas J, Convery RS, Moore K, Cash DM, van Swieten J, Jiskoot L, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Rotondo E, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonca A, Tagliavini F, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Otto M, Warren JD, Rohrer JD, Genetic Ftd Initiative G (2020) Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort. Cortex 133:384–398. https://doi.org/10.1016/j.cortex.2020.08.023

    Article  PubMed  PubMed Central  Google Scholar 

  80. Jiskoot LC, Poos JM, Vollebergh ME, Franzen S, van Hemmen J, Papma JM, van Swieten JC, Kessels RPC, van den Berg E (2021) Emotion recognition of morphed facial expressions in presymptomatic and symptomatic frontotemporal dementia, and Alzheimer’s dementia. J Neurol 268(1):102–113. https://doi.org/10.1007/s00415-020-10096-y

    Article  CAS  PubMed  Google Scholar 

  81. Couto B, Manes F, Montanes P, Matallana D, Reyes P, Velasquez M, Yoris A, Baez S, Ibanez A (2013) Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia. Front Hum Neurosci 7:467. https://doi.org/10.3389/fnhum.2013.00467

    Article  PubMed  PubMed Central  Google Scholar 

  82. Hutchings R, Palermo R, Piguet O, Kumfor F (2017) Disrupted face processing in frontotemporal dementia: a review of the clinical and neuroanatomical evidence. Neuropsychol Rev 27(1):18–30. https://doi.org/10.1007/s11065-016-9340-2

    Article  PubMed  Google Scholar 

  83. Shany-Ur T, Poorzand P, Grossman SN, Growdon ME, Jang JY, Ketelle RS, Miller BL, Rankin KP (2012) Comprehension of insincere communication in neurodegenerative disease: lies, sarcasm, and theory of mind. Cortex 48(10):1329–1341. https://doi.org/10.1016/j.cortex.2011.08.003

    Article  PubMed  Google Scholar 

  84. Piguet O, Hornberger M, Mioshi E, Hodges JR (2011) Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management. Lancet Neurol 10(2):162–172. https://doi.org/10.1016/S1474-4422(10)70299-4

    Article  PubMed  Google Scholar 

  85. Gola KA, Shany-Ur T, Pressman P, Sulman I, Galeana E, Paulsen H, Nguyen L, Wu T, Adhimoolam B, Poorzand P, Miller BL, Rankin KP (2017) A neural network underlying intentional emotional facial expression in neurodegenerative disease. Neuroimage Clin 14:672–678. https://doi.org/10.1016/j.nicl.2017.01.016

    Article  PubMed  PubMed Central  Google Scholar 

  86. O’Callaghan C, Bertoux M, Irish M, Shine JM, Wong S, Spiliopoulos L, Hodges JR, Hornberger M (2016) Fair play: social norm compliance failures in behavioural variant frontotemporal dementia. Brain 139(Pt 1):204–216. https://doi.org/10.1093/brain/awv315

    Article  PubMed  Google Scholar 

  87. Fittipaldi S, Ibanez A, Baez S, Manes F, Sedeno L, Garcia AM (2019) More than words: social cognition across variants of primary progressive aphasia. Neurosci Biobehav Rev 100:263–284. https://doi.org/10.1016/j.neubiorev.2019.02.020

    Article  PubMed  Google Scholar 

  88. Bejanin A, Chetelat G, Laisney M, Pelerin A, Landeau B, Merck C, Belliard S, de La Sayette V, Eustache F, Desgranges B (2017) Distinct neural substrates of affective and cognitive theory of mind impairment in semantic dementia. Soc Neurosci 12(3):287–302. https://doi.org/10.1080/17470919.2016.1168314

    Article  PubMed  Google Scholar 

  89. Duval C, Bejanin A, Piolino P, Laisney M, de La Sayette V, Belliard S, Eustache F, Desgranges B (2012) Theory of mind impairments in patients with semantic dementia. Brain 135(Pt 1):228–241. https://doi.org/10.1093/brain/awr309

    Article  PubMed  Google Scholar 

  90. Downey LE, Mahoney CJ, Buckley AH, Golden HL, Henley SM, Schmitz N, Schott JM, Simpson IJ, Ourselin S, Fox NC, Crutch SJ, Warren JD (2015) White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration. Neuroimage Clin 8:640–651. https://doi.org/10.1016/j.nicl.2015.06.005

    Article  PubMed  PubMed Central  Google Scholar 

  91. Rankin KP, Salazar A, Gorno-Tempini ML, Sollberger M, Wilson SM, Pavlic D, Stanley CM, Glenn S, Weiner MW, Miller BL (2009) Detecting sarcasm from paralinguistic cues: anatomic and cognitive correlates in neurodegenerative disease. Neuroimage 47(4):2005–2015. https://doi.org/10.1016/j.neuroimage.2009.05.077

    Article  PubMed  Google Scholar 

  92. Irish M, Hodges JR, Piguet O (2014) Right anterior temporal lobe dysfunction underlies theory of mind impairments in semantic dementia. Brain 137(Pt 4):1241–1253. https://doi.org/10.1093/brain/awu003

    Article  PubMed  Google Scholar 

  93. Borroni B, Alberici A, Agosti C, Cosseddu M, Padovani A (2009) Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy. Int Psychogeriatr 21(3):463–468. https://doi.org/10.1017/S1041610209008862

    Article  PubMed  Google Scholar 

  94. Irish M, Kumfor F, Hodges JR, Piguet O (2013) A tale of two hemispheres: contrasting socioemotional dysfunction in right-versus left-lateralised semantic dementia. Dement Neuropsychol 7(1):88–95. https://doi.org/10.1590/S1980-57642013DN70100014

    Article  PubMed  PubMed Central  Google Scholar 

  95. Chan D, Anderson V, Pijnenburg Y, Whitwell J, Barnes J, Scahill R, Stevens JM, Barkhof F, Scheltens P, Rossor MN, Fox NC (2009) The clinical profile of right temporal lobe atrophy. Brain 132(Pt 5):1287–1298. https://doi.org/10.1093/brain/awp037

    Article  PubMed  Google Scholar 

  96. Kumfor F, Miller L, Lah S, Hsieh S, Savage S, Hodges JR, Piguet O (2011) Are you really angry? The effect of intensity on facial emotion recognition in frontotemporal dementia. Soc Neurosci 6(5–6):502–514. https://doi.org/10.1080/17470919.2011.620779

    Article  PubMed  Google Scholar 

  97. Miller LA, Hsieh S, Lah S, Savage S, Hodges JR, Piguet O (2012) One size does not fit all: face emotion processing impairments in semantic dementia, behavioural-variant frontotemporal dementia and Alzheimer’s disease are mediated by distinct cognitive deficits. Behav Neurol 25(1):53–60. https://doi.org/10.3233/BEN-2012-0349

    Article  PubMed  Google Scholar 

  98. Borghesani V, Narvid J, Battistella G, Shwe W, Watson C, Binney RJ, Sturm V, Miller Z, Mandelli ML, Miller B, Gorno-Tempini ML (2019) “Looks familiar, but I do not know who she is”: the role of the anterior right temporal lobe in famous face recognition. Cortex 115:72–85. https://doi.org/10.1016/j.cortex.2019.01.006

    Article  PubMed  PubMed Central  Google Scholar 

  99. Binney RJ, Henry ML, Babiak M, Pressman PS, Santos-Santos MA, Narvid J, Mandelli ML, Strain PJ, Miller BL, Rankin KP, Rosen HJ, Gorno-Tempini ML (2016) Reading words and other people: a comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia. Cortex 82:147–163. https://doi.org/10.1016/j.cortex.2016.05.014

    Article  PubMed  PubMed Central  Google Scholar 

  100. Rankin KP, Gorno-Tempini ML, Allison SC, Stanley CM, Glenn S, Weiner MW, Miller BL (2006) Structural anatomy of empathy in neurodegenerative disease. Brain 129(Pt 11):2945–2956. https://doi.org/10.1093/brain/awl254

    Article  PubMed  Google Scholar 

  101. Shdo SM, Ranasinghe KG, Gola KA, Mielke CJ, Sukhanov PV, Miller BL, Rankin KP (2018) Deconstructing empathy: neuroanatomical dissociations between affect sharing and prosocial motivation using a patient lesion model. Neuropsychologia 116(Pt A):126–135. https://doi.org/10.1016/j.neuropsychologia.2017.02.010

    Article  PubMed  Google Scholar 

  102. Sollberger M, Rosen HJ, Shany-Ur T, Ullah J, Stanley CM, Laluz V, Weiner MW, Wilson SM, Miller BL, Rankin KP (2014) Neural substrates of socioemotional self-awareness in neurodegenerative disease. Brain Behav 4(2):201–214. https://doi.org/10.1002/brb3.211

    Article  PubMed  PubMed Central  Google Scholar 

  103. Rosen HJ, Allison SC, Ogar JM, Amici S, Rose K, Dronkers N, Miller BL, Gorno-Tempini ML (2006) Behavioral features in semantic dementia vs other forms of progressive aphasias. Neurology 67(10):1752–1756. https://doi.org/10.1212/01.wnl.0000247630.29222.34

    Article  CAS  PubMed  Google Scholar 

  104. Battista P, Capozzo R, Rizzo G, Zecca C, Anastasia A, De Blasi R, Logroscino G (2019) Early pathological gambling in co-occurrence with semantic variant primary progressive aphasia: a case report. Clin Interv Aging 14:727–733. https://doi.org/10.2147/CIA.S197484

    Article  PubMed  PubMed Central  Google Scholar 

  105. Woolley JD, Strobl EV, Sturm VE, Shany-Ur T, Poorzand P, Grossman S, Nguyen L, Eckart JA, Levenson RW, Seeley WW, Miller BL, Rankin KP (2015) Impaired recognition and regulation of disgust is associated with distinct but partially overlap** patterns of decreased gray matter volume in the ventroanterior insula. Biol Psychiatry 78(7):505–514. https://doi.org/10.1016/j.biopsych.2014.12.031

    Article  PubMed  PubMed Central  Google Scholar 

  106. Marshall CR, Hardy CJD, Russell LL, Clark CN, Dick KM, Brotherhood EV, Bond RL, Mummery CJ, Schott JM, Rohrer JD, Kilner JM, Warren JD (2017) Impaired interoceptive accuracy in semantic variant primary progressive Aphasia. Front Neurol 8:610. https://doi.org/10.3389/fneur.2017.00610

    Article  PubMed  PubMed Central  Google Scholar 

  107. Van Langenhove T, Leyton CE, Piguet O, Hodges JR (2016) Comparing longitudinal behavior changes in the primary progressive aphasias. J Alzheimers Dis 53(3):1033–1042. https://doi.org/10.3233/JAD-160010

    Article  PubMed  Google Scholar 

  108. Hazelton JL, Irish M, Hodges JR, Piguet O, Kumfor F (2017) Cognitive and affective empathy disruption in non-fluent primary progressive aphasia syndromes. Brain Impairment 18(1):117–129

    Article  Google Scholar 

  109. Kumfor F, Ibanez A, Hutchings R, Hazelton JL, Hodges JR, Piguet O (2018) Beyond the face: how context modulates emotion processing in frontotemporal dementia subtypes. Brain 141(4):1172–1185. https://doi.org/10.1093/brain/awy002

    Article  PubMed  Google Scholar 

  110. Kumfor F, Irish M, Hodges JR, Piguet O (2013) Discrete neural correlates for the recognition of negative emotions: insights from frontotemporal dementia. PLoS One 8(6):e67457. https://doi.org/10.1371/journal.pone.0067457

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Marshall CR, Hardy CJD, Russell LL, Bond RL, Sivasathiaseelan H, Greaves C, Moore KM, Agustus JL, van Leeuwen JEP, Wastling SJ, Rohrer JD, Kilner JM, Warren JD (2019) The functional neuroanatomy of emotion processing in frontotemporal dementias. Brain 142(9):2873–2887. https://doi.org/10.1093/brain/awz204

    Article  PubMed  PubMed Central  Google Scholar 

  112. Piguet O, Leyton CE, Gleeson LD, Hoon C, Hodges JR (2015) Memory and emotion processing performance contributes to the diagnosis of non-semantic primary progressive aphasia syndromes. J Alzheimers Dis 44(2):541–547. https://doi.org/10.3233/JAD-141854

    Article  PubMed  Google Scholar 

  113. Rohrer JD, Sauter D, Scott S, Rossor MN, Warren JD (2012) Receptive prosody in nonfluent primary progressive aphasias. Cortex 48(3):308–316. https://doi.org/10.1016/j.cortex.2010.09.004

    Article  PubMed  PubMed Central  Google Scholar 

  114. Gomez-Tortosa E, Rigual R, Prieto-Jurczynska C, Mahillo-Fernandez I, Guerrero-Lopez R, Perez-Perez J, Sainz MJ (2016) Behavioral evolution of progressive semantic aphasia in comparison with nonfluent aphasia. Dement Geriatr Cogn Disord 41(1–2):1–8. https://doi.org/10.1159/000439521

    Article  PubMed  Google Scholar 

  115. Rohrer JD, Warren JD (2010) Phenomenology and anatomy of abnormal behaviours in primary progressive aphasia. J Neurol Sci 293(1–2):35–38. https://doi.org/10.1016/j.jns.2010.03.012

    Article  PubMed  PubMed Central  Google Scholar 

  116. Burrell JR, Halliday GM, Kril JJ, Ittner LM, Gotz J, Kiernan MC, Hodges JR (2016) The frontotemporal dementia-motor neuron disease continuum. Lancet 388(10047):919–931. https://doi.org/10.1016/S0140-6736(16)00737-6

    Article  PubMed  Google Scholar 

  117. van der Hulst EJ, Bak TH, Abrahams S (2015) Impaired affective and cognitive theory of mind and behavioural change in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 86(11):1208–1215. https://doi.org/10.1136/jnnp-2014-309290

    Article  PubMed  Google Scholar 

  118. Meier SL, Charleston AJ, Tippett LJ (2010) Cognitive and behavioural deficits associated with the orbitomedial prefrontal cortex in amyotrophic lateral sclerosis. Brain 133(11):3444–3457. https://doi.org/10.1093/brain/awq254

    Article  PubMed  Google Scholar 

  119. Carluer L, Mondou A, Buhour MS, Laisney M, Pelerin A, Eustache F, Viader F, Desgranges B (2015) Neural substrate of cognitive theory of mind impairment in amyotrophic lateral sclerosis. Cortex 65:19–30. https://doi.org/10.1016/j.cortex.2014.12.010

    Article  PubMed  Google Scholar 

  120. Staios M, Fisher F, Lindell AK, Ong B, Howe J, Reardon K (2013) Exploring sarcasm detection in amyotrophic lateral sclerosis using ecologically valid measures. Front Hum Neurosci 7:178. https://doi.org/10.3389/fnhum.2013.00178

    Article  PubMed  PubMed Central  Google Scholar 

  121. Cavallo M, Adenzato M, Macpherson SE, Karwig G, Enrici I, Abrahams S (2011) Evidence of social understanding impairment in patients with amyotrophic lateral sclerosis. PLoS One 6(10):e25948. https://doi.org/10.1371/journal.pone.0025948

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. Burke T, Elamin M, Bede P, Pinto-Grau M, Lonergan K, Hardiman O, Pender N (2016) Discordant performance on the “Reading the Mind in the Eyes” Test, based on disease onset in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 17(7–8):467–472. https://doi.org/10.1080/21678421.2016.1177088

    Article  CAS  PubMed  Google Scholar 

  123. Trojsi F, Siciliano M, Russo A, Passaniti C, Femiano C, Ferrantino T, De Liguoro S, Lavorgna L, Monsurro MR, Tedeschi G, Santangelo G (2016) Theory of mind and its neuropsychological and quality of life correlates in the early stages of amyotrophic lateral sclerosis. Front Psychol 7:1934. https://doi.org/10.3389/fpsyg.2016.01934

    Article  PubMed  PubMed Central  Google Scholar 

  124. Cerami C, Dodich A, Canessa N, Crespi C, Iannaccone S, Corbo M, Lunetta C, Consonni M, Scola E, Falini A, Cappa SF (2014) Emotional empathy in amyotrophic lateral sclerosis: a behavioural and voxel-based morphometry study. Amyotroph Lateral Scler Frontotemporal Degener 15(1–2):21–29. https://doi.org/10.3109/21678421.2013.785568

    Article  PubMed  Google Scholar 

  125. Strong MJ, Abrahams S, Goldstein LH, Woolley S, McLaughlin P, Snowden J, Mioshi E, Roberts-South A, Benatar M, HortobaGyi T, Rosenfeld J, Silani V, Ince PG, Turner MR (2017) Amyotrophic lateral sclerosis—frontotemporal spectrum disorder (ALS-FTSD): revised diagnostic criteria. Amyotroph Lateral Scler Frontotemporal Degener 18(3–4):153–174. https://doi.org/10.1080/21678421.2016.1267768

    Article  PubMed  PubMed Central  Google Scholar 

  126. Arshad F, Paplikar A, Mekala S, Varghese F, Purushothaman VV, Kumar DJ, Shingavi L, Vengalil S, Ramakrishnan S, Yadav R, Pal PK, Nalini A, Alladi S (2020) Social cognition deficits are pervasive across both classical and overlap frontotemporal dementia syndromes. Dement Geriatr Cogn Dis Extra 10(3):115–126. https://doi.org/10.1159/000511329

    Article  PubMed  PubMed Central  Google Scholar 

  127. Oh SI, Oh KW, Kim HJ, Park JS, Kim SH (2016) Impaired perception of emotional expression in amyotrophic lateral sclerosis. J Clin Neurol 12(3):295–300. https://doi.org/10.3988/jcn.2016.12.3.295

    Article  PubMed  PubMed Central  Google Scholar 

  128. Zimmerman EK, Eslinger PJ, Simmons Z, Barrett AM (2007) Emotional perception deficits in amyotrophic lateral sclerosis. Cogn Behav Neurol 20(2):79–82. https://doi.org/10.1097/WNN.0b013e31804c700b

    Article  PubMed  Google Scholar 

  129. Aho-Ozhan HE, Keller J, Heimrath J, Uttner I, Kassubek J, Birbaumer N, Ludolph AC, Lule D (2016) Perception of emotional facial expressions in Amyotrophic Lateral Sclerosis (ALS) at behavioural and brain metabolic level. PLoS One 11(10):e0164655. https://doi.org/10.1371/journal.pone.0164655

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  130. Bora E (2017) Meta-analysis of social cognition in amyotrophic lateral sclerosis. Cortex 88:1–7. https://doi.org/10.1016/j.cortex.2016.11.012

    Article  PubMed  Google Scholar 

  131. Girardi A, MacPherson SE, Abrahams S (2011) Deficits in emotional and social cognition in amyotrophic lateral sclerosis. Neuropsychology 25(1):53–65. https://doi.org/10.1037/a0020357

    Article  PubMed  Google Scholar 

  132. Martins AP, Prado LGR, Lillo P, Mioshi E, Teixeira AL, de Souza LC (2019) Deficits in emotion recognition as markers of frontal behavioral dysfunction in amyotrophic lateral sclerosis. J Neuropsychiatry Clin Neurosci 31(2):165–169. https://doi.org/10.1176/appi.neuropsych.18040086

    Article  PubMed  Google Scholar 

  133. Andrews SC, Staios M, Howe J, Reardon K, Fisher F (2017) Multimodal emotion processing deficits are present in amyotrophic lateral sclerosis. Neuropsychology 31(3):304–310. https://doi.org/10.1037/neu0000323

    Article  PubMed  Google Scholar 

  134. Savage SA, Lillo P, Kumfor F, Kiernan MC, Piguet O, Hodges JR (2014) Emotion processing deficits distinguish pure amyotrophic lateral sclerosis from frontotemporal dementia. Amyotroph Lateral Scler Frontotemporal Degener 15(1–2):39–46. https://doi.org/10.3109/21678421.2013.809763

    Article  PubMed  Google Scholar 

  135. Watermeyer TJ, Brown RG, Sidle KC, Oliver DJ, Allen C, Karlsson J, Ellis CM, Shaw CE, Al-Chalabi A, Goldstein LH (2015) Executive dysfunction predicts social cognition impairment in amyotrophic lateral sclerosis. J Neurol 262(7):1681–1690. https://doi.org/10.1007/s00415-015-7761-0

    Article  PubMed  Google Scholar 

  136. Lule D, Kurt A, Jurgens R, Kassubek J, Diekmann V, Kraft E, Neumann N, Ludolph AC, Birbaumer N, Anders S (2005) Emotional responding in amyotrophic lateral sclerosis. J Neurol 252(12):1517–1524. https://doi.org/10.1007/s00415-005-0907-8

    Article  PubMed  Google Scholar 

  137. Pender N, Pinto-Grau M, Hardiman O (2020) Cognitive and behavioural impairment in amyotrophic lateral sclerosis. Curr Opin Neurol 33(5):649–654. https://doi.org/10.1097/WCO.0000000000000862

    Article  PubMed  Google Scholar 

  138. Saxon JA, Thompson JC, Harris JM, Richardson AM, Langheinrich T, Rollinson S, Pickering-Brown S, Chaouch A, Ealing J, Hamdalla H, Young CA, Blackburn D, Majeed T, Gall C, Jones M, Snowden JS (2020) Cognition and behaviour in frontotemporal dementia with and without amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 91(12):1304–1311. https://doi.org/10.1136/jnnp-2020-323969

    Article  PubMed  Google Scholar 

  139. Caga J, Tu S, Dharmadasa T, Tse NY, Zoing MC, Huynh W, Mahoney C, Ahmed RM, Kiernan MC (2021) Apathy is associated with parietal cortical-subcortical dysfunction in ALS. Cortex. https://doi.org/10.1016/j.cortex.2021.02.029

    Article  PubMed  Google Scholar 

  140. Radakovic R, Stephenson L, Newton J, Crockford C, Swingler R, Chandran S, Abrahams S (2017) Multidimensional apathy and executive dysfunction in amyotrophic lateral sclerosis. Cortex 94:142–151. https://doi.org/10.1016/j.cortex.2017.06.023

    Article  PubMed  Google Scholar 

  141. Witgert M, Salamone AR, Strutt AM, Jawaid A, Massman PJ, Bradshaw M, Mosnik D, Appel SH, Schulz PE (2010) Frontal-lobe mediated behavioral dysfunction in amyotrophic lateral sclerosis. Eur J Neurol 17(1):103–110. https://doi.org/10.1111/j.1468-1331.2009.02801.x

    Article  CAS  PubMed  Google Scholar 

  142. Gibbons ZC, Richardson A, Neary D, Snowden JS (2008) Behaviour in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 9(2):67–74. https://doi.org/10.1080/17482960701642437

    Article  PubMed  Google Scholar 

  143. Burrell JR, Hodges JR, Rowe JB (2014) Cognition in corticobasal syndrome and progressive supranuclear palsy: a review. Mov Disord 29(5):684–693. https://doi.org/10.1002/mds.25872

    Article  PubMed  Google Scholar 

  144. Toller G, Brown J, Sollberger M, Shdo SM, Bouvet L, Sukhanov P, Seeley WW, Miller BL, Rankin KP (2018) Individual differences in socioemotional sensitivity are an index of salience network function. Cortex 103:211–223. https://doi.org/10.1016/j.cortex.2018.02.012

    Article  PubMed  PubMed Central  Google Scholar 

  145. Ghosh BC, Rowe JB, Calder AJ, Hodges JR, Bak TH (2009) Emotion recognition in progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 80(10):1143–1145. https://doi.org/10.1136/jnnp.2008.155846

    Article  CAS  PubMed  Google Scholar 

  146. Ghosh BC, Calder AJ, Peers PV, Lawrence AD, Acosta-Cabronero J, Pereira JM, Hodges JR, Rowe JB (2012) Social cognitive deficits and their neural correlates in progressive supranuclear palsy. Brain 135(Pt 7):2089–2102. https://doi.org/10.1093/brain/aws128

    Article  PubMed  PubMed Central  Google Scholar 

  147. Pontieri FE, Assogna F, Stefani A, Pierantozzi M, Meco G, Benincasa D, Colosimo C, Caltagirone C, Spalletta G (2012) Sad and happy facial emotion recognition impairment in progressive supranuclear palsy in comparison with Parkinson’s disease. Parkinsonism Relat Disord 18(7):871–875. https://doi.org/10.1016/j.parkreldis.2012.04.023

    Article  PubMed  Google Scholar 

  148. Aarsland D, Litvan I, Larsen JP (2001) Neuropsychiatric symptoms of patients with progressive supranuclear palsy and Parkinson’s disease. J Neuropsychiatry Clin Neurosci 13(1):42–49. https://doi.org/10.1176/jnp.13.1.42

    Article  CAS  PubMed  Google Scholar 

  149. Gerstenecker A, DuffMast KB, Litvan I, Group E-PS (2013) Behavioral abnormalities in progressive supranuclear palsy. Psychiatry Res 210(3):1205–1210. https://doi.org/10.1016/j.psychres.2013.08.045

    Article  PubMed  Google Scholar 

  150. Santangelo G, Cuoco S, Pellecchia MT, Erro R, Barone P, Picillo M (2018) Comparative cognitive and neuropsychiatric profiles between Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy. J Neurol 265(11):2602–2613. https://doi.org/10.1007/s00415-018-9038-x

    Article  PubMed  Google Scholar 

  151. Ahmed Z, Josephs KA, Gonzalez J, DelleDonne A, Dickson DW (2008) Clinical and neuropathologic features of progressive supranuclear palsy with severe pallido-nigro-luysial degeneration and axonal dystrophy. Brain 131(Pt 2):460–472. https://doi.org/10.1093/brain/awm301

    Article  PubMed  Google Scholar 

  152. Rittman T, Coyle-Gilchrist IT, Rowe JB (2016) Managing cognition in progressive supranuclear palsy. Neurodegener Dis Manag 6(6):499–508. https://doi.org/10.2217/nmt-2016-0027

    Article  PubMed  PubMed Central  Google Scholar 

  153. Schrag A, Selai C, Davis J, Lees AJ, Jahanshahi M, Quinn N (2003) Health-related quality of life in patients with progressive supranuclear palsy. Mov Disord 18(12):1464–1469. https://doi.org/10.1002/mds.10583

    Article  PubMed  Google Scholar 

  154. Poletti M, Bonuccelli U (2012) Impairment of affective theory of mind in corticobasal degeneration. J Neuropsychiatry Clin Neurosci 24(1):E7. https://doi.org/10.1176/appi.neuropsych.11010021

    Article  PubMed  Google Scholar 

  155. Southi N, Honan CA, Hodges JR, Piguet O, Kumfor F (2019) Reduced capacity for empathy in corticobasal syndrome and its impact on carer burden. Int J Geriatr Psychiatry 34(3):497–503. https://doi.org/10.1002/gps.5045

    Article  PubMed  Google Scholar 

  156. Kluger BM, Heilman KM (2007) Dysfunctional facial emotional expression and comprehension in a patient with corticobasal degeneration. Neurocase 13(3):165–168. https://doi.org/10.1080/13554790701448192

    Article  PubMed  Google Scholar 

  157. Kumfor F, Sapey-Triomphe LA, Leyton CE, Burrell JR, Hodges JR, Piguet O (2014) Degradation of emotion processing ability in corticobasal syndrome and Alzheimer’s disease. Brain 137(Pt 11):3061–3072. https://doi.org/10.1093/brain/awu246

    Article  PubMed  Google Scholar 

  158. Litvan I, Cummings JL, Mega M (1998) Neuropsychiatric features of corticobasal degeneration. J Neurol Neurosurg Psychiatry 65(5):717–721. https://doi.org/10.1136/jnnp.65.5.717

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  159. Kertesz A, McMonagle P (2010) Behavior and cognition in corticobasal degeneration and progressive supranuclear palsy. J Neurol Sci 289(1–2):138–143. https://doi.org/10.1016/j.jns.2009.08.036

    Article  PubMed  Google Scholar 

  160. Lansdall CJ, Coyle-Gilchrist ITS, Vazquez Rodriguez P, Wilcox A, Wehmann E, Robbins TW, Rowe JB (2019) Prognostic importance of apathy in syndromes associated with frontotemporal lobar degeneration. Neurology 92(14):e1547–e1557. https://doi.org/10.1212/WNL.0000000000007249

    Article  PubMed  PubMed Central  Google Scholar 

  161. Cordato NJ, Duggins AJ, Halliday GM, Morris JG, Pantelis C (2005) Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy. Brain 128(Pt 6):1259–1266. https://doi.org/10.1093/brain/awh508

    Article  CAS  PubMed  Google Scholar 

  162. Brooks BR, Miller RG, Swash M, Munsat TL (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1(5):293–299

    Article  CAS  Google Scholar 

  163. Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL (2017) Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord 32(6):853–864

    Article  Google Scholar 

  164. Armstrong MJ, Litvan I, Lang AE, Bak TH, Bhatia KP, Borroni B, Boxer AL, Dickson DW, Grossman M, Hallett M (2013) Criteria for the diagnosis of corticobasal degeneration. Neurology 80(5):496–503

    Article  Google Scholar 

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Funding

European Research Council (StG-2016_714388_NeuroTRACK).

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Authors and Affiliations

  1. Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy

    Maria Antonietta Magno, Elisa Canu, Federica Agosta & Massimo Filippi

  2. Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

    Federica Agosta & Massimo Filippi

  3. Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy

    Massimo Filippi

  4. Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

    Massimo Filippi

  5. Vita-Salute San Raffaele University, Milan, Italy

    Federica Agosta & Massimo Filippi

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  3. Federica Agosta
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  4. Massimo Filippi
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Contributions

M.A. Magno, E. Canu, F. Agosta, and M. Filippi: design/conceptualization of study; interpretation of data; drafted and revised the manuscript for intellectual content.

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Correspondence to Massimo Filippi.

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Conflicts of interest

M.A. Magno report no disclosures. E. Canu has received research supports from the Italian Ministry of Health. F. Agosta is Section Editor of NeuroImage: Clinical; received compensation for consulting services and/or speaking activities from Philips, Biogen Idec and Roche; and receives or has received research supports from the Italian Ministry of Health, AriSLA (Fondazione Italiana di Ricerca per la SLA), and the European Research Council. M. Filippi is Editor-in-Chief of the Journal of Neurology, Associate Editor of Human Brain Map**, Associate Editor of Radiology, and Associate Editor of Neurological Sciences; received compensation for consulting services and/or speaking activities from Alexion, Almirall, Bayer, Biogen, Celgene, Eli Lilly, Genzyme, Merck-Serono, Novartis, Roche, Sanofi, Takeda, and Teva Pharmaceutical Industries; and receives research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA).

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Magno, M.A., Canu, E., Agosta, F. et al. Measuring social cognition in frontotemporal lobar degeneration: a clinical approach. J Neurol 269, 2227–2244 (2022). https://doi.org/10.1007/s00415-021-10889-9

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  • DOI: https://doi.org/10.1007/s00415-021-10889-9

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