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Frontotemporal lobar degeneration in the “Annual of the Pathological Autopsy Cases in Japan”

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Abstract

Background

Good accuracy for the clinical diagnosis of frontotemporal lobar degeneration (FTLD) by specialists in an early onset dementia clinic has been reported.

Objective

To assess the diagnostic accuracy of FTLD in an entire population, without restrictions related to patient age or diagnosing physician.

Methods

Volumes of the “Annual of the Pathological Autopsy Cases in Japan,” with reports of 130,105 autopsies throughout Japan from 2007 to 2016, were descriptively analyzed.

Results

There were 219 patients with clinical and/or pathological diagnoses of FTLD. The sensitivity and specificity were 24.5% and 76.9%, respectively. Age at death for pathologically confirmed patients was 76.3 ± 11.6 years (mean ± standard deviation). Overlooked patients died significantly older than patients with an accurate clinical diagnosis.

Conclusions

Clinical diagnoses of FTLD had low sensitivity. Furthermore, the age at death of pathologically confirmed patients suggests that FTLD affects a wide age range and is not restricted to presenile individuals.

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Availability of data and materials

Anonymized data are available by request from the corresponding author.

Code availability

Not applicable.

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Acknowledgements

This study was funded by The Rehabilitation Research Fund of Social Welfare Corporation Nagoya City Rehabilitation Agency. We deeply appreciate the Japanese Society of Pathology for publishing “Annual of the Pathological Autopsy Cases in Japan” each year. We are especially grateful to Dr. Hidehiro Kabasawa, former director of Nagoya City Rehabilitation Center Hospital, to the late Dr. Michitaka Matsubara, former Director of Department of Planning and Research, Nagoya City Rehabilitation Center, and to the late Professor Tomoyuki Shirai, former President of Nagoya City Rehabilitation Center and Professor Emeritus of Nagoya City University, for their kind assistances.

Funding

This study was funded by The Rehabilitation Research Fund of Social Welfare Corporation Nagoya City Rehabilitation Agency.

Author information

Authors and Affiliations

  1. Department of Neurology, Nagoya City Rehabilitation Center, 1-2, Mikan-yama, Yatomi-cho, Mizuho, Nagoya, 467-8622, Japan

    Yoshihiko Horimoto, Chikako Sato, Ayuko Suzuki, Aki Inagaki, Toshihisa Tajima & Hiroaki Hibino

  2. Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University, Mizuho, Nagoya, 467-8601, Japan

    Hiroshi Inagaki

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  1. Yoshihiko Horimoto
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Contributions

All authors have read the manuscript and approved this submission. Yoshihiko Horimoto: Research project (Conception, Organization, Execution), Recruitment of patients who met the inclusion criteria, Analyzing patient information, Statistical Analysis (Design, Execution, Review and Critique), Manuscript Preparation (Writing of the first draft, Review and Critique). Chikako Sato: Recruitment of patients who met the inclusion criteria, Manuscript Preparation (Review and Critique). Ayuko Suzuki: Recruitment of patients who met the inclusion criteria, Manuscript Preparation (Review and Critique). Aki Inagaki: Recruitment of patients who met the inclusion criteria, Manuscript Preparation (Review and Critique). Toshihisa Tajima: Recruitment of patients who met the inclusion criteria, Manuscript Preparation (Review and Critique). Hiroaki Hibino: Recruitment of patients who met the inclusion criteria, Manuscript Preparation (Review and Critique). Hiroshi Inagaki: Research project (Execution), Negotiations with the Japanese Society of Pathology, Manuscript Preparation (Review and Critique).

Corresponding author

Correspondence to Yoshihiko Horimoto.

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Conflicts of interest

The authors declare that they have no conflict of interest or competing interests. The authors also declare that they have no financial or non-financial interests that are directly or indirectly related to the work submitted for publication.

Ethical approval

This study was a retrospective review of published data; ethics committee approval was therefore not required. The study was conducted in accordance with the Declaration of Helsinki, 1975, and was authorized by the Japanese Society of Pathology.

Informed consent

Because this study was a retrospective review of published data, consent of participants was not applicable.

Consent for publication

Because this study was a retrospective review of published data, consent for publication was not applicable.

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Horimoto, Y., Sato, C., Suzuki, A. et al. Frontotemporal lobar degeneration in the “Annual of the Pathological Autopsy Cases in Japan”. J Neurol (2024). https://doi.org/10.1007/s00415-024-12528-5

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