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Unusual effects of a nanoporous gold substrate on cell adhesion and differentiation because of independent multi-branch signaling of focal adhesions
A variety of cell behaviors, such as cell adhesion, motility, and fate, can be controlled by substrate characteristics such as surface topology and...
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Intracellular pH-responsive iron-catechin nanoparticles with osteogenic/anti-adipogenic and immunomodulatory effects for efficient bone repair
Osteoimmunomodulation was identified as a new and important strategy to enhance osteogenic differentiation together with other osteogenic approaches....
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The Emerging Role of Curcumin in Inducing Neuronal Trans-differentiation of Mesenchymal Stem Cells: a Review
PurposeThis review focused on the effectiveness of utilising natural compounds like curcumin to induce the trans-differentiation of mesenchymal stem...
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Monocytes and pyrophosphate promote mesenchymal stem cell viability and early osteogenic differentiation
Pyrophosphate-containing calcium phosphate implants promote osteoinduction and bone regeneration. The role of pyrophosphate for inflammatory...
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Tailoring the Microenvironment of Cells Towards Osteogenic Differentiation Using Multilayers of Glycosaminoglycans and Growth Factor Immobilization
The extracellular matrix (ECM) provides the structural support and signals important for cell fate, tissue homeostasis and regeneration....
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Black Phosphorus Nanoparticles Promote Osteogenic Differentiation of EMSCs Through Upregulated TG2 Expression
At bio-safe concentrations, black phosphorus nanoparticles activated TG2, and promote the expression of ECM, which further promoted osteogenic...
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Plasma Electrolytic Oxidation (PEO) Coated CP-Ti: Wear Performance on Reciprocating Mode and Chondrogenic–Osteogenic Differentiation
Biocompatible oxide coatings obtained by plasma electrolyte oxidation (PEO) have been used to improve the surface properties of bone grafts made of...
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Enhanced osteogenic differentiation of alendronate-conjugated nanodiamonds for potential osteoporosis treatment
BackgroundAlendronate (Alen) is promising material used for bone-targeted drug delivery due to its high bone affinity and therapeutic effects on bone...
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Rediscovery of poly(ethylene glycol)s as a cryoprotectant for mesenchymal stem cells
BackgroundA medium containing dimethyl sulfoxide (DMSO) (10% v/v) is most widely used for cell cryopreservation at –196 °C. However, residual DMSO...
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Xenogeneic Stem Cell–Induced Cardiac Progenitor Cells Regenerated Infarcted Myocardium in Rat Model
PurposeWe aim to investigate the role of stem cell–based regenerative medicine to repair or regrow the infarcted myocardium and restore normal...
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Non-homogeneous dispersion of graphene in polyacrylonitrile substrates induces a migrastatic response and epithelial-like differentiation in MCF7 breast cancer cells
BackgroundRecent advances from studies of graphene and graphene-based derivatives have highlighted the great potential of these nanomaterials as...
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Chondrogenic Differentiation of Mesenchymal Stem Cells from Rat Bone Marrow on the Elastic Modulus of Electrospun Silk Fibroin Scaffolds
AbstractTissue engineering can be considered a promising tool for cartilage regeneration in which mesenchymal stem cells (MSCs) and a suitable...
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AFM Assessment of the Mechanical Properties of Stem Cells During Differentiation
The dynamic mechanical force transmitted through microenvironments during tissue formation and regeneration continuously impacts the mechanics of...
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Mild heat treatment in vitro potentiates human adipose stem cells: delayed aging and improved quality for long term culture
BackgroundMesenchymal stem cells (MSCs) have gained significant attention for diverse biomedical applications, including cell-based therapy. Hence,...
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Self-Assembling Peptide Nanofibers Anchored Parathyroid Hormone Derivative for Bone Tissue Engineering
Parathyroid hormone (PTH) has been used for bone regeneration through intermittent subcutaneous injection; however, the topical administration of PTH...
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Investigating Neurogenic Differentiation of Dental Pulp Stem Cells Using PLA and Graphene Thin-Film and Electrospun Fiber Scaffolds in Vitro
Dental pulp derived cells are pluripotent stem cells which can be differentiated along odontogenic, osteogenic, adipogenic, or neurogenic lineages....
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Size-controlled human adipose-derived stem cell spheroids hybridized with single-segmented nanofibers and their effect on viability and stem cell differentiation
BackgroundFabrication of three-dimensional stem cell spheroids have been studied to improve stem cell function, but the hypoxic core and limited...
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Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)
The use of mesenchymal stem cells (MSCs) for clinical purposes has skyrocketed in the past decade. Their multilineage differentiation potentials and...
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Investigatıon of Neurosphere Activity of Injectable 3D Graphene Bioink Biomaterial
PurposeThe aim of this study includes the comparative examination of neurosphere formation by WJ-derived mesenchymal stem cells in both 2D media and...
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Self-organized insulin-producing β-cells differentiated from human omentum-derived stem cells and their in vivo therapeutic potential
BackgroundHuman omentum-derived mesenchymal stem cells (hO-MSCs) possess great potential to differentiate into multiple lineages and have...
