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Passaging of gingival fibroblasts from periodontally healthy and diseased sites upregulates osteogenesis-related genes
To investigate biological processes of the periodontium, in vitro primary cell models have been established. To study the biology of the gingiva,...
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Boric Acid Reverses Nicotine-Induced Cytokine Expressions of Human Gingival Fibroblasts
Nicotine, the major bioactive ingredient in tobacco, is a major risk factor for periodontal disease and destruction. Nicotine has been shown to...
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Development of 3D gingival in vitro models using primary gingival cells
Since March 2013, animal testing for toxicity evaluation of cosmetic ingredients is banned in Europe. This directive applies to all personal care...
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Effects of an aryl hydrazone derivative of naproxen on HepG2 liver cancer and HGF gingival fibroblasts cell lines
Nonsteroidal anti-inflammatory drugs are suggested to have anti-cancer effects in many studies, but elucidation of mode of action remains a...
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Cl-amidine attenuates lipopolysaccharide-induced inflammation in human gingival fibroblasts via the JNK/MAPK, NF-κB, and Nrf2 signalling pathways
Cl-amidine has been reported to have anti-inflammatory properties in a variety of diseases. However, the role of Cl-amidine in periodontal disease...
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Combined use of hydrogen-rich water and enzyme-digested edible bird’s nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents
Gingival wound healing plays a critical role in maintaining oral health. However, this process can be delayed by oxidative stress and excessive...
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Use of Human Gingival Fibroblasts for Pre-Vascularization Strategies in Oral Tissue Engineering
Background:Cocultures of human gingival fibrobasts (hGF) and endothelial cells could enhance regeneration and repair models as well as improve...
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Xeno-free generation of human induced pluripotent stem cells from donor-matched fibroblasts isolated from dermal and oral tissues
BackgroundInduced pluripotent stem cells (iPS) can be generated from various somatic cells and can subsequently be differentiated to multiple cell...
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D-aspartic acid protects against gingival fibroblasts inflammation by suppressing pyroptosis
BackgroundPeri-implantitis is the main cause of dental implant failure, which is associated with pyroptosis. The roles of D-aspartic acid (D-Asp) on...
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The Effects of Injectable Platelet-Rich Fibrin and Advanced-Platelet Rich Fibrin on Gingival Fibroblast Cell Vitality, Proliferation, Differentiation
Background:Injectable Platelet Rich Fibrin (I-PRF) and Advanced-Platelet Rich Fibrin (A-PRF) are autologous materials derived from patients’ blood...
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Long-term cryopreservation of whole gingival tissue
Stem cells obtained from the body tissue, such as adipose tissue, dental pulp and gingival tissue. Fresh tissue is often used to isolate and culture...
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Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice
Periodontitis is a highly prevalent disease leading to uncontrolled osteoclastic jawbone resorption and ultimately edentulism; however, the disease...
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A high-throughput, 28-day, microfluidic model of gingival tissue inflammation and recovery
Nearly half of American adults suffer from gum disease, including mild inflammation of gingival tissue, known as gingivitis. Currently, advances in...
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Insulin-producing cell clusters derived from human gingival mesenchymal stem cells as a model for diabetes research
BackgroundThe human gingiva-derived mesenchymal stem cells (hGMSCs) possess a great potential to develop the cell-based therapy for diabetes due to...
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Efficient isolation of human gingival stem cells in a new serum-free medium supplemented with platelet lysate and growth hormone for osteogenic differentiation enhancement
BackgroundThe use of distant autografts to restore maxillary bone defects is clinically challenging and has unpredictable outcomes. This variation...
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The spatial transcriptomic landscape of human gingiva in health and periodontitis
The gingiva is a key oral barrier that protects oral tissues from various stimuli. A loss of gingival tissue homeostasis causes periodontitis, one of...
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Gingival mesenchymal stem cell therapy, immune cells, and immunoinflammatory application
MSC-based therapeutic strategies have proven to be incredibly effective. Robust self-renewal, multilineage differentiation, and potential for tissue...
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EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma
Lymph node metastasis, primarily caused by the migration of oral squamous cell carcinoma (OSCC) cells, stands as a crucial prognostic marker. We have...
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Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method
Background:An in vitro study on rapid culturing method of human gingival fibroblast cells (HGFCs) was established to investigate the potential use...
