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TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness
IntroductionWe previously reported that TRPM7 regulates glioma cells’ stemness through STAT3. In addition, we demonstrated that FOSL1 is a response...
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The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis
Cancer or endothelial cells preferably catabolize glucose through aerobic glycolysis rather than oxidative phosphorylation. Intracellular ionic...
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Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
BackgroundSepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by...
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TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt
Hyperaldosteronism causes cardiovascular disease as well as hypomagnesemia. Mechanisms are ill-defined but dysregulation of TRPM7, a Mg 2+ -permeable...
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Involvement of TRPM7 Channel on the Induction of Diabetic Neuropathic Pain in Mice: Protective Role of Selenium and Curcumin
Excessive levels of the mitochondrial reactive oxygen radical (mitSOX) and Ca 2+ influx were found to cause neuropathic pain in patients with diabetes...
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Structural mechanism of TRPM7 channel regulation by intracellular magnesium
Zn 2+ , Mg 2+ and Ca 2+ are essential divalent cations implicated in many metabolic processes and signalling pathways. An emerging new paradigm is that...
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TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel
Animal cells can regulate their volume after swelling by the regulatory volume decrease (RVD) mechanism. In epithelial cells, RVD is attained through...
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CD82-TRPM7-Numb signaling mediates age-related cognitive impairment
Aging is a crucial cause of cognitive decline and a major risk factor for Alzheimer’s disease (AD); however, AD’s underlying molecular mechanisms...
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Identification of RNA reads encoding different channels in isolated rat ventricular myocytes and the effect of cell stretching on L-type Ca2+current
BackgroundThe study aimed to identify transcripts of specific ion channels in rat ventricular cardiomyocytes and determine their potential role in...
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Simulated Microgravity Changes the Number of Mechanically Gated and Mechanosensitive Ion Channels Genes Transcripts in Rat Ventricular Cardiomyocytes
AbstractThe mechanoelectrical feedback in the heart is based on the work of mechanically gated (MGCs) and mechanosensitive (MSCs) channels. Since...
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Role of the chanzyme TRPM7 in the nervous system in health and disease
The channel kinase (chanzyme) transient receptor potential melastatin-like 7 (TRPM7) has a unique dual protein structure composed of an ion channel...
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Structural and functional comparison of magnesium transporters throughout evolution
Magnesium (Mg 2+ ) is the most prevalent divalent intracellular cation. As co-factor in many enzymatic reactions, Mg 2+ is essential for protein...
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Map** the expression of transient receptor potential channels across murine placental development
Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is...
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Magnesium transport in the aglomerular kidney of the Gulf toadfish (Opsanus beta)
Despite having an aglomerular kidney, Gulf toadfish can survive in water ranging from nearly fresh up to 70 parts per thousand salinity. In...
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Proteomic studies of VEGFR2 in human placentas reveal protein associations with preeclampsia, diabetes, gravidity, and labor
VEGFR2 (Vascular endothelial growth factor receptor 2) is a central regulator of placental angiogenesis. The study of the VEGFR2 proteome of...
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Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice
TRIC-A and TRIC-B proteins form homotrimeric cation-permeable channels in the endoplasmic reticulum (ER) and nuclear membranes and are thought to...
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Interaction of NF-κB and FOSL1 drives glioma stemness
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor; GBM’s inevitable recurrence suggests that glioblastoma stem cells...
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Emerging Anticancer Metabolite, Carvacrol, and its Action Mechanism
Across the world, cancer is a major health problem in the population, causing ten million deaths a year in most countries. Studies on a promising...
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Insight into the pathophysiological advances and molecular mechanisms underlying cerebral stroke: current status
Molecular pathways involved in cerebral stroke are diverse. The major pathophysiological events that are observed in stroke comprises of...
