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Role of mechanically-sensitive cation channels Piezo1 and TRPV4 in trabecular meshwork cell mechanotransduction
Glaucoma is one of the leading causes of irreversible blindness in developed countries, and intraocular pressure (IOP) is primary and only treatable...
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Sample Preparation from Plant Tissue for Gas Chromatography–Mass Spectrometry (GC-MS)we
Metabolites are intermediate products formed during metabolism. Metabolites play different roles, including providing energy, supporting structure,...
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Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3
BackgroundMelanocytes are an essential part of the epidermis, and their regeneration has received much attention because propagation of human adult...
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Label-free LC–MS/MS proteomics analyses reveal proteomic changes in oxidative stress and the SOD antioxidant strategy in TM cells
BackgroundTreatment for glaucoma has traditionally been limited to reducing intraocular pressure (IOP). Inhibiting oxidative stress in the trabecular...
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NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health
Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory...
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The Piezo1 ion channel in glaucoma: a new perspective on mechanical stress
Glaucomatous optic nerve damage caused by pathological intraocular pressure elevation is irreversible, and its course is often difficult to control....
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ER Membrane Lipid Composition and Metabolism: Lipidomic Analysis
Plant ER membranes are the major site of biosynthesis of several lipid families (phospholipids, sphingolipids, neutral lipids such as sterols and...
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Acute cannabinoids impair association learning via selectively enhancing synaptic transmission in striatonigral neurons
BackgroundCannabinoids and their derivatives attract strong interest due to the tremendous potential of their psychoactive effects for treating...
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Isolation of Plasmodesmata Membranes for Lipidomic and Proteomic Analysis
Plasmodesmata (PD) are membranous intercellular nanochannels crossing the plant cell wall to connect adjacent cells in plants. Our understanding of...
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GC-MS/MS Profiling of Plant Metabolites
Gas chromatography coupled to electron ionization (EI) quadrupole mass spectrometry (GC-MS) is currently one of the most developed and robust...
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Metabolic pathway of tebuconazole by soil fungus Cunninghamella elegans ATCC36112
Tebuconazole is the most widely used fungicide in agriculture. Due to its long half-life, tebuconazole residues can be found in the environment media...
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Biodegradation and metabolic pathway of quinalphos by Cunninghamella elegans ATCC36112
Quinalphos is a long-term, wide-spectrum organophosphate insecticide with residual problems in the natural environment. Cunninghamella elegans ( C....
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GC-MS based comparative metabolomic analysis of human cancellous bone reveals the critical role of linoleic acid metabolism in femur head necrosis
IntroductionFemur head necrosis (FHN) is a challenging clinical disease with unclear underlying mechanism, which pathologically is associated with...
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A comparative review on methods of detection and quantification of mycotoxins in solid food and feed: a focus on cereals and nuts
Many emerging factors and circumstances urge the need to develop and optimize the detection and quantification techniques of mycotoxins in solid food...
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Optimization of fecal sample homogenization for untargeted metabolomics
IntroductionFecal samples are highly complex and heterogeneous, containing materials at various stages of digestion. The heterogeneity and complexity...
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TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find...
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Effect of Treated Wastewater on the Distribution of Antibiotic-Resistant Microorganisms in the Aquatic Environment
AbstractThe effect of wastewater treatment plants in Pushchino, Russia, on abundance of antibiotic-resistant microorganisms and determinants of...
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Evaluation of normalization strategies for GC-based metabolomics
IntroductionFor many samples studied by GC-based metabolomics applications, extensive sample preparation involving extraction followed by a two-step...
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An exploratory investigation of the CSF metabolic profile of HIV in a South African paediatric cohort using GCxGC-TOF/MS
IntroductionBecause cerebrospinal fluid (CSF) samples are difficult to obtain for paediatric HIV, few studies have attempted to profile...
