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The Nuclear Localization Signal of NF-κB p50 Enters the Cells via Syndecan-Mediated Endocytosis and Inhibits NF-κB Activity
It is well established that cationic peptides can enter cells following attachment to polyanionic membrane components. We report that the basic...
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Interaction of NF-κB and FOSL1 drives glioma stemness
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor; GBM’s inevitable recurrence suggests that glioblastoma stem cells...
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NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB...
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The role of NF-κB in carcinogenesis of cervical cancer: opportunities and challenges
The nuclear factor-κB (NF-κB) family, consisting of several transcription factors, has been implicated in the regulation of cell proliferation and...
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Role of Transcription Factor NF-κB in Neuroimmunoendocrine Mechanisms of Respiratory Diseases
AbstractOne of the current challenges of biomedicine is to elucidate the multicomponent and multilevel mechanism of integrated...
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NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression
Gliomas are highly invasive and chemoresistant cancers, making them challenging to treat. Chronic inflammation is a key driver of glioma progression...
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Insights on the NF-κB system in polycystic ovary syndrome, attractive therapeutic targets
The nuclear factor κappa B (NF-κB) signaling plays a well-known function in inflammation and regulates a wide variety of biological processes....
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Quantitative Imaging Analysis of NF-κB for Mathematical Modeling Applications
Mathematical models can integrate different types of experimental datasets, reconstitute biological systems in silico, and identify previously...
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SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1
Metastasis accounts for the major cause of colorectal cancer (CRC) related mortality due to the lack of effective treatments. In this study, we...
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NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive type of lung cancer driven by combined loss of the tumor suppressors RB1 and TP53 . SCLC is highly...
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Mechanism of miR-7 mediating TLR4/TRAF6/NF-κB inflammatory pathway in colorectal cancer
This study is aimed at investigating the roles of Toll-like receptor 4 (TLR4) and microRNA-7 (miR-7) in colorectal cancer (CRC) development and...
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Lactate dehydrogenase A promotes nasopharyngeal carcinoma progression through the TAK1/NF-κB Axis
BackgroundNasopharyngeal carcinoma (NPC) is a malignant tumor that originates in the nasopharyngeal mucosa and is common in China and Southeast Asian...
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Thrombospondin-2 Couples Pressure-Promoted Chondrogenesis through NF-κB Signaling
BACKGROUND:Our previous studies found that the mechanical stimulation promote chondrogenic differentiation of bone marrow mesenchymal stem cells...
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Cucumber seed polypeptides regulate RANKL-induced osteoclastogenesis through OPG/RANKL/RANK and NF-κB
Postmenopausal osteoporosis (PMOP) is a common disease that endangers the health of elderly women. Cucumber seeds have shown excellent therapeutic...
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Rutin alleviates Sjogren’s syndrome via CaR/NLRP3/NF-κB signal pathway
Sjogren’s syndrome (SS) is an autoimmune disease. Its mechanism and treatment methods are unclear. The purpose of this study was to investigate the...
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Strontium Attenuates LPS-Induced Inflammation via TLR4/MyD88/NF-κB Pathway in Bovine Ruminal Epithelial Cells
Subacute ruminal acidosis (SARA) is a common nutritional metabolic disease in ruminants that causes significant economic losses to dairy farming....
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Overexpression of TRIM44 mediates the NF-κB pathway to promote the progression of ovarian cancer
BackgroundOvarian cancer (OC) is the second most commonly seen cancer in the US, and patients with OC are commonly diagnosed in the advanced stage....
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IDO1 facilitates esophageal carcinoma progression by driving the direct binding of NF-κB and CXCL10
Esophageal carcinoma (EC), one of the most lethal human malignancies, lacks effective targeted therapies. Indoleamine 2,3-dioxygenase 1 (IDO1) plays...
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Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells
Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that...
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FGF21 Inhibits Hypoxia/Reoxygenation-induced Renal Tubular Epithelial Cell Injury by Regulating the PPARγ/NF-κB Signaling Pathway
As a predominant trigger of acute kidney injury, renal ischemia-reperfusion injury can cause permanent renal impairment, and the effective therapies...
