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Interaction of NF-κB and FOSL1 drives glioma stemness
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor; GBM’s inevitable recurrence suggests that glioblastoma stem cells...
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TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness
IntroductionWe previously reported that TRPM7 regulates glioma cells’ stemness through STAT3. In addition, we demonstrated that FOSL1 is a response...
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m6A demethylation of FOSL1 mRNA protects hepatoma cells against necrosis under glucose deprivation
Stress-adaptive mechanisms enabling cancer cells to survive under glucose deprivation remain elusive. N 6 -methyladenosine (m 6 A) modification plays...
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HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells
BackgroundVasculogenic mimicry (VM) is an enigmatic physiological feature that influences blood supply within glioblastoma (GBM) tumors for their...
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Exosome-transmitted FOSL1 from cancer-associated fibroblasts drives colorectal cancer stemness and chemo-resistance through transcriptionally activating ITGB4
Cancer-associated fibroblasts (CAFs) have been proved to facilitate colorectal cancer (CRC) development, either with boosting chemo-resistance by...
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ALKBH5 promotes the progression of infantile hemangioma through regulating the NEAT1/miR-378b/FOSL1 axis
Our work aims to investigate long non-coding RNA (lncRNA) N6-methyladenosine (m 6 A) modification and its role in infantile hemangioma (IH). The mRNA...
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Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis
Basal-like breast cancers (BLBCs) are among the most aggressive cancers, partly due to their enrichment of cancer stem cells (CSCs). Breast CSCs can...
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Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation
BackgroundAs one of the most common malignancies, esophageal cancer has two subtypes, squamous cell carcinoma and adenocarcinoma, arising from...
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H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition
BackgroundThe exit from pluripotency or pluripotent-somatic transition (PST) landmarks an event of early mammalian embryonic development,...
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The transcriptomic signature of respiratory sensitizers using an alveolar model
Environmental contaminants are ubiquitous in the air we breathe and can potentially cause adverse immunological outcomes such as respiratory...
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Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer
Kras-activating mutations display the highest incidence in pancreatic ductal adenocarcinoma. Pancreatic inflammation accelerates mutant Kras-driven...
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Decoding the principle of cell-fate determination for its reverse control
Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is determined by intricate and nonlinear interactions among...
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Transcriptome profiling revealed early vascular smooth muscle cell gene activation following focal ischemic stroke in female rats – comparisons with males
BackgroundWomen account for 60% of all stroke deaths and are more often permanently disabled than men, despite their higher observed stroke...
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Particulate matter-induced gene expression patterns in human-derived cells based on 11 public gene expression datasets
BackgroundExposure to particulate matter (PM) and house dust mite (HDM) can change the expression patterns of inflammation-, oxidative stress-, and...
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DeepCAC: a deep learning approach on DNA transcription factors classification based on multi-head self-attention and concatenate convolutional neural network
Understanding gene expression processes necessitates the accurate classification and identification of transcription factors, which is supported by...
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Mature neurons from iPSCs unveil neurodegeneration-related pathways in mucopolysaccharidosis type II: GSK-3β inhibition for therapeutic potential
Mucopolysaccharidosis (MPS) type II is caused by a deficiency of iduronate-2-sulfatase and is characterized by the accumulation of glycosaminoglycans...
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Identification of key apoptosis-related genes and immune infiltration in the pathogenesis of psoriasis
BackgroundPsoriasis is a condition in which skin cells build up and form itchy scales and dry patches. It is also considered a common lifelong...
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Dual inhibition of P38 MAPK and JNK pathways preserves stemness markers and alleviates premature activation of muscle stem cells during isolation
BackgroundAdult skeletal muscle contains resident muscle stem cells (MuSC) with high myogenic and engraftment potentials, making them suitable for...
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Now that We Got There, What Next?
As seen in the protocols in this book, the opportunities to pursue work at the cellular and molecular work in salamanders have considerably broadened...
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Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice
RationaleGenetic studies have proved the involvement of Tuberous sclerosis complex subunit 2 (Tsc2) in aortic aneurysm. However, the exact role of...
