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Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells
BackgroundIntestinal barrier plays key roles in maintaining intestinal homeostasis. Inflammation damage can severely destroy the intestinal integrity...
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Effect of embelin on inhibition of cell growth and induction of apoptosis in Acanthamoeba castellanii
Acanthamoeba castellanii is the causative agent of fatal encephalitis and blinding keratitis. Current therapies remain a challenge, hence there is a...
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Qualitative Analysis of Few Bioactive Compounds from Ardisia solanacea Roxb., Odisha, India
To maintain the novelty of plant bioactive compounds within several formulations and to delimit usage of adulterants, suitable cultivable alternate...
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Identification of Plant-Based Bio-Actives in the Treatment of Ulcerative Colitis Using Virtual Screening and In Vivo Approaches
Ulcerative colitis (UC) is a kind of persistent inflammatory bowel disease that is a root cause for lifelong soreness in the colon and rectum...
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Phytochemical analysis, antioxidant activities and optimized extraction of embelin from different genotypes of Embelia ribes Burm f.: a woody medicinal climber from Western Ghats of India
Medicinal importance of Embelia ribes Burm f. is known since ancient time. Its berries are the main ingredient in Vidanga’ or ‘Baibidanga’—a...
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Evaluating genetic diversity of geographically diverse populations of Embelia ribes Burm f., a highly medicinal woody liana from the Western Ghats of India, using random amplified polymorphic DNA (RAPD) and intersimple sequence repeats (ISSR) markers
BackgroundEmbelia ribes Burm f. (Primulaceae) is a medicinal and vulnerable woody liana distributed throughout India. Embelin, a well-recognized...
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Indian Herbs with Hepato-Protectant Potentials
India has a fine history of herbs used as medicine, based upon different therapeutic systems. Indian Ayurvedic pharmacopoeia has recorded around 540...
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Prognostic risk assessment model and drug sensitivity analysis of colon adenocarcinoma (COAD) based on immune-related lncRNA pairs
PurposeThe aim of this study was to identify and screen long non-coding RNA (lncRNA) associated with immune genes in colon cancer, construct...
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Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome
Inflammatory bowel disease (IBD) is considered a chronic inflammatory and multifactorial disease of the gastrointestinal tract. Crohn’s disease (CD)...
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Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2
The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. Here we show that BIRC2 accumulates in the...
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Repression of resistance mechanisms of Pseudomonas aeruginosa: implications of the combination of antibiotics and phytoconstituents
Antimicrobial resistance is a prevalent problem witnessed globally and creating an alarming situation for the treatment of infections caused by...
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Nanotechnology in Delivery and Targeting of Phytochemicals for Lifestyle Diseases
In many cases, conventional therapeutics are not able to cure diseases in a proper and safe manner. Conversely, plants and their derivatives have...
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Extracellular Matrix Remodeling Enzymes as Targets for Natural Antiangiogenic Compounds
Angiogenesis, or new blood vessels formation, comprises a series of tight regulated and coordinated steps guided by the balance between proangiogenic...
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Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell–cell interactions in the pathophysiology of neurological disease
Neuroserpin is an axonally secreted serpin that is involved in regulating plasminogen and its enzyme activators, such as tissue plasminogen activator...
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Plant Disease Management Using Anti-quorum Sensing Cues with an Emphasis on Pseudomonas syringae Pathovars
Plant microbiomes encompass different communities of microorganisms either as epiphytic regions such as phyllosphere, or rhizosphere regions and as...
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Neuroserpin: structure, function, physiology and pathology
Neuroserpin is a serine protease inhibitor identified in a search for proteins implicated in neuronal axon growth and synapse formation. Since its...
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Essential Oils: From Traditional to Modern-Day Applications with Special Reference to Medicinal and Aromatic Plants in India
Essential oils (EOs) are complex mixtures of volatile secondary metabolites extracted from different parts of aromatic plants such as leaves,...
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Forest-Based Medicinal Plants for Cancer Cure
Cancer is the world’s second leading cause of death after cardiovascular disease. Medicinal plants are important natural sources of herbs that have...
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The Chemistry of Antidiabetic Plants
A great many plant species that demonstrate activity against hyperglycemia are listed in literature. They are known to contain classes of compounds...
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Bioinformatic analysis and experimental validation of cuproptosis-related LncRNA as a novel biomarker for prognosis and immunotherapy of oral squamous cell carcinoma
BackgroundThe novel form of regulatory cell death, cuproptosis, is characterized by proteotoxicity, which ultimately leads to cell death. Its...
