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p53-dependent DNA repair during the DNA damage response requires actin nucleation by JMY
The tumour suppressor p53 is a nuclear transcription factor with key roles during DNA damage to enable a variety of cellular responses including cell...
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DNA Damage Responses Methods and Protocols
This volume provides detailed methods and key approaches used to mechanistically study DNA damage, as well as the factors involved in the damage...
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Involvement of H2A variants in DNA damage response of zygotes
Phosphorylated H2AX, known as γH2AX, forms in response to genotoxic insults in somatic cells. Despite the high abundance of H2AX in zygotes, the...
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ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response
Downregulation of the urea cycle enzyme argininosuccinate synthase (ASS1) in multiple tumors is associated with a poor prognosis partly because of...
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The DNA damage response pathway regulates the expression of the immune checkpoint CD47
CD47 is a cell surface ligand expressed on all nucleated cells. It is a unique immune checkpoint protein acting as “don’t eat me” signal to prevent...
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Interaction between lncRNAs and RNA-binding proteins (RBPs) influences DNA damage response in cancer chemoresistance
The DNA damage response (DDR) is a crucial cellular signaling pathway activated in response to DNA damage, including damage caused by chemotherapy....
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Interactome Profiling of DNA Damage Response (DDR) Mediators with Immunoprecipitation-Mass Spectrometry
Immunoprecipitation-mass spectrometry (IP-MS) is a versatile tool to probe for global protein–protein interactions (PPIs) in biological samples. Such...
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Expression variations of DNA damage response genes ATM and ATR in blood cancer patients
Hematological malignancies (HM) constitute a variety of cancers originating in blood, bone marrow (BM), and lymphatic systems. During the last two...
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The mechanistic role of cardiac glycosides in DNA damage response and repair signaling
Cardiac glycosides (CGs) are a class of bioactive organic compounds well-known for their application in treating heart disease despite a narrow...
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The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer
AXL is a receptor tyrosine kinase that is often overexpressed in cancers. It contributes to pathophysiology in cancer progression and therapeutic...
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Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells
Females have a lower probability to develop somatic cancers and a better response to chemotherapy than males. However, the reasons for these...
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Filamentous nuclear actin regulation of PML NBs during the DNA damage response is deregulated by prelamin A
Nuclear actin participates in a continuously expanding list of core processes within eukaryotic nuclei, including the maintenance of genomic...
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Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response inhibitors
Combination therapy is well established as a key intervention strategy for cancer treatment, with the potential to overcome monotherapy resistance...
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The regulatory subunits of CK2 complex mediate DNA damage response and virulence in Candida Glabrata
BackgroundCandida glabrata which belongs to normal microbiota, has caused significant concern worldwide due to its high prevalence and drug...
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Checkpoint and Coordinated Cellular Responses to DNA Damage
The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
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When DNA-damage responses meet innate and adaptive immunity
When cells proliferate, stress on DNA replication or exposure to endogenous or external insults frequently results in DNA damage. DNA-Damage Response...
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Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage
Our previous studies have shown that p53 isoform expression is altered in breast cancer and related to prognosis. In particular, a high ∆40p53:p53α...
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Assessing SIRT7 Activity In Vivo and In Vitro in Response to DNA Damage
The class III histone deacetylase (HDACs) also known as sirtuins (SIRTs 1–7) are ubiquitously expressed, but SIRT7 mainly resides as nucleolar...
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Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response
In response to DNA double-strand breaks (DSBs), DNA damage repair factors are recruited to DNA lesions and form nuclear foci. However, the underlying...
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Identification of a DNA damage repair-related LncRNA signature for predicting the prognosis and immunotherapy response of hepatocellular carcinoma
BackgroundDNA damage repair (DDR) may affect tumorigenesis and therapeutic response in hepatocellular carcinoma (HCC). Long noncoding RNAs (LncRNAs)...
