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Association between polymorphisms of anti-inflammatory gene alleles and periodontitis risk in a Chinese Han population
ObjectiveCytokines that mediate the immune responses are important in the pathogenesis of periodontitis. The genetic polymorphisms of IL-10, TNFAIP3...
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New insights into the genetics of mandibular retrognathism: novel candidate genes
PurposeMandibular retrognathism (MR) is a common skeletal malocclusion in humans with a strong genetic component. Single nucleotide polymorphisms...
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Chromatin conformation of human oral epithelium can identify orofacial cleft missing functional variants
Genome-wide association studies (GWASs) are the most widely used method to identify genetic risk loci associated with orofacial clefts (OFC)....
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Genetic and Developmental Pathology
A genetic disorder is a disease caused in whole or in part by a change in the DNA sequence away from the normal sequence. These are categorised as...
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Gene variants for the WNT pathway are associated with severity in periodontal disease
ObjectiveStudies of Wnt variants-related to bone resorption in periodontitis are limited. The aim of this study was to establish the genotype and...
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Medication-related osteonecrosis of the jaw (MRONJ) and eNOS Polymorphisms in multiple myeloma patients: a single center experience
BackgroundMultiple myeloma (MM) constitutes approximately 10% of hematological malignancies. Bisphosphonates have established themselves in solid...
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Genetic Aspects of Oral Submucous Fibrosis
Oral cancer is a multistep process which may be preceded by oral potentially malignant disorders (OPMDs), such as oral submucous fibrosis (OSF) [1]....
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Family-based GWAS for dental class I malocclusion and clefts
BackgroundIndividuals born with cleft lip and/or palate who receive corrective surgery regularly have abnormal growth in the midface region such that...
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Identification of copy neutral loss of heterozygosity on chromosomes 1p, 1q, and 6p among nonsyndromic cleft lip and/or without cleft palate with hypodontia
BackgroundNonsyndromic cleft lip and/or without cleft palate (NSCL/P) with or without hypodontia is a common developmental aberration in humans and...
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TUSC3, p53 and p21 genetic association with development of oral submucous fibrosis and oral squamous cell carcinoma among addictive tobacco chewers of Pakistan
BackgroundThis study delves into the intricate landscape of oral cancer, a global concern with a high incidence in Asian countries. We focus on oral...
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Blisters and Ulcers on the Soft Palate : Pemphigus
Pemphigus is a potentially life-threatening autoimmune disease that causes blisters and erosions of the mucous membrane and the skin. The autoimmune...
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Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis
ObjectivesThe FTO gene has been reported as an obesity-associated gene and is also considered a risk gene for osteoarthritis (OA). However, its exact...
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Association of exposure factors and their causal relationship with oral cancer: A Mendelian randomization study
ObjectivesThere is a strong association among risk factors for oral cancer (ORCA), such as smoking, alcohol consumption, fiber intake, and red meat...
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Association of interleukin-8 polymorphism (+ 781 C/T) with the risk of oral Lichen Planus disease
BackgroundOral Lichen Planus (OLP) is a chronic inflammatory mucosal disease. The pathogenesis of OLP is unknown. The Single Nucleotide Polymorphism...
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Evaluation of matrix metalloproteinase-1, -2, -3, -7, and -13 gene polymorphisms in patients with chronic periodontitis and healthy controls
ObjectivesThe current study aimed to investigate the association of matrix metalloproteinase- (MMP-) 1, -2, -3, -7, and -13 gene polymorphisms with...
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Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men
ObjectiveSLC22A4/5 single nucleotide polymorphisms (SNPs) have been reported to affect inflammatory diseases. We report the relationship of these...
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Involvement of interlukin-17A (IL-17A) gene polymorphism and interlukin-23 (IL-23) level in the development of peri-implantitis
BackgroundDental implantation has been practiced since ancient times and has gone through several stages. Dentists use dental implants to support...
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AMELX gene association to early childhood caries in south-Indian children: a case–control study
PurposeGenetic variants of AMELX gene can affect the protein content, organization of enamel prisms, microstructure and microhardness of the enamel,...
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Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study
BackgroundGlutathione S-transferases (GSTs) play important roles in protecting cells against oxidative stress and toxic chemicals. This study aimed...
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The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development
The cranial neural crest plays a fundamental role in orofacial development and morphogenesis. Accordingly, mutations with impact on the cranial...
