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Global signal peptide profiling reveals principles of selective Sec61 inhibition
Cotransins target the Sec61 translocon and inhibit the biogenesis of an undefined subset of secretory and membrane proteins. Remarkably, cotransin...
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Thermostable in vitro transcription-translation compatible with microfluidic droplets
BackgroundIn vitro expression involves the utilization of the cellular transcription and translation machinery in an acellular context to produce one...
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Serum lipidomic profiling by UHPLC-MS/MS may be able to detect early-stage endometrial cancer
Nowadays, screening for endometrial cancer (EC) primarily relies on clinical symptoms and imaging, which makes it difficult to detect early-stage...
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Quantitation of Aldosterone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Accurate determination of serum and plasma aldosterone is essential for screening, diagnosis, and subtype classification of primary aldosteronism...
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Nucleic Acid Based Testing (NABing): A Game Changer Technology for Public Health
Timely and accurate detection of the causal agent of a disease is crucial to restrict suffering and save lives. Mere symptoms are often not enough to...
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Interaction Between Soy Protein Isolate (SPI) and Water-Soluble Persian Gum to Form Stable Colloidal Complexes
This study aimed to investigate the electrostatic interaction between soy protein isolate (SPI) and water-soluble part of Persian gum (PG) as...
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Linear Calibration Methods
Unary linear regression is the simplest linear regression with the formula of y = b0 + bx + ε, where x is an observable and controllable variable,...
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Identification of Ubiquitination-Associated Proteins Using 2D-DIGE
Ubiquitination is a post-translational modification, in which a small regulatory protein (~8.6 kDa) is tagged as a single moiety or as a chain to...
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A novel electrochemical platform for assay of alkaline phosphatase based on amifostine and ATRP signal amplification
Alkaline phosphatase (ALP), an important hydrolase involved in dephosphorylation, is a common clinical indicator of many diseases. In the present...
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Synthetic acid stress-tolerance modules improve growth robustness and lysine productivity of industrial Escherichia coli in fermentation at low pH
BackgroundDuring fermentation, industrial microorganisms encounter multiple stresses that inhibit cell growth and decrease fermentation yields, in...
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Chitosan/luminol/AgNPs nanocomposite for electrochemiluminescent determination of prostate-specific antigen
A green, environmentally friendly protocol was developed for ultrasensitive and highly specific recognition of prostate-specific antigen (PSA) based...
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High-throughput phase elucidation of polycrystalline materials using serial rotation electron diffraction
Rapid phase elucidation of polycrystalline materials is essential for develo** new materials of chemical, pharmaceutical and industrial interest....
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Design and Selection of Ionic Liquids Via COSMO for Pharmaceuticals and Medicine
Ionic liquids (ILs) have been used significantly in pharmaceutics and medicine because of their exceptional “green” properties and tailor-made...
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Interaction of Atomic Oxygen with a Polycrystalline Au Surface: XPS and TPD Study
AbstractAdsorption of atomic oxygen on the surface of polycrystalline gold is studied in detail by XPS and TPD methods. It is shown that the action...
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In situ formation of reactive (di)gallenes for bond activation
Access to reactive low-valent main-group complexes capable of bond activation commonly requires multistep syntheses, limiting options for electronic...
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CRISPR Deletion of miR-27 Impacts Recombinant Protein Production in CHO Cells
MicroRNAs represent an interesting group of regulatory molecules with the unique ability of a single miRNA able to regulate the expression of...
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Scaffold Generator: a Java library implementing molecular scaffold functionalities in the Chemistry Development Kit (CDK)
The concept of molecular scaffolds as defining core structures of organic molecules is utilised in many areas of chemistry and cheminformatics, e.g....
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Computational Approach and Its Application in the Nutraceutical Industry
In recent years, application of the computational approach, a predictive tool, in food and nutritional sciences has outweighed classical analytical...
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Identification of potent, non-toxic, selective CDK2 inhibitor through the pharmacophore-based scaffold hop**, molecular dynamics simulation-assisted molecular docking study, Lee Richard contour map analysis, and ADMET properties
In the present research, efforts were made to develop the novel, selective, and nontoxic CDK2 inhibitors. Previously reported potent CDK2 inhibitors...
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Read-Across and Quantitative Structure–Activity Relationships (QSAR) for Making Predictions and Data Gap-Filling
Read-across is originally a non-statistical grou** approach for data gap filling. The grou** of chemicals may be done based on similarities in...