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Circular RNA AGAP1 Stimulates Immune Escape and Distant Metastasis in Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most representative subtype of renal cancer, with a highly aggressive phenotype and extremely poor...
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Circ_0082374 Promotes the Tumorigenesis and Suppresses Ferroptosis in Non-small Cell Lung Cancer by Up-Regulating GPX4 Through Sequestering miR-491-5p
Circular RNAs (circRNAs) have been identified to be dysregulated in non-small cell lung cancer (NSCLC) and implicated in the progression of this...
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Curcumin Loaded onto Folic acid Carbon dots as a Potent drug Delivery System for Antibacterial and Anticancer Applications
Numerous malignancies have been shown to be successfully treated with Curcumin. Despite its promising effects, Curcumin has limitations in clinical...
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Hsa_circ_0084912 Drives the Progression of Cervical Cancer Via Regulating miR-429/SOX2 Pathway
We focus on hsa_circ_0084912’s role in Cervical cancer (CC) and its molecular pathways. In order to determine the expression of Hsa_circ_0084912,...
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miR-497/195 Cluster Affects the Development of Colorectal Cancer by Targeting FRA1
The miR-497-195 cluster facilitates the occurrence and development of cancer. This study aims to investigate whether the miR-195-497 cluster could...
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Regulatory Components of Oxidative Stress and Inflammation and Their Complex Interplay in Carcinogenesis
Cancer progression is closely linked to oxidative stress (OS) inflammation. OS is caused by an imbalance between the amount of reactive oxygen...
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Activation of MAL2 by RAD21 inhibits the expression of MHC-I in immune evasion of endometrial cancer
CD8 + T cells are the primary mediators of anticancer immunity, and modulation of the CD8 + T cell response has been a central focus of immunotherapy...
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Anti-cancer Effect of Hyoscyamus muticus Extract via Its Activation of Fas/FasL-ASK1-p38 Pathway
Hyoscyamus muticus L. is a traditional medicine used as antispasmodic and sedative. Herein, we aimed to determine the phytochemical constituents and...
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Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer
Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are...
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Recent insights into the microRNA and long non-coding RNA-mediated regulation of stem cell populations
Stem cells are undifferentiated cells that have multi-lineage differentiation. The transition from self-renewal to differentiation requires rapid and...
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miR-197-3p reduces epithelial–mesenchymal transition by targeting ABCA7 in ovarian cancer cells
The present study was designed to explore the role of microRNA-197-3p in regulating the epithelial–mesenchymal cellular transition in ovarian cancer....
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Assessing MTT and sulforhodamine B cell proliferation assays under multiple oxygen environments
Cell proliferation can be measured directly by counting cells or indirectly using assays that quantitate total protein or metabolic activity....
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A Novel Copper Oxide Nanoparticle Conjugated by Thiosemicarbazone Promote Apoptosis in Human Breast Cancer Cell Line
The current study highlights the apoptotic activity of copper oxide (CuO) nanoparticles functionalized by Glutamic acid and conjugated by...
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Novel strategies for designing regenerative skin products for accelerated wound healing
Healthy skin protects from pathogens, water loss, ultraviolet rays, and also maintains homeostasis conditions along with sensory perceptions in...
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Polysaccharide-Based Hydrogels for Bioengineering 3D Tumor Models
Cancer is the leading cause of death worldwide and its incidence is expected to rise. Despite overwhelming efforts to design innovative preclinical...
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MiR-485-5p Suppress the Malignant Characteristics of the Lung Adenocarcinoma via Targeting NADPH Quinone Oxidoreductase-1 to Inhibit the PI3K/Akt
Lung adenocarcinoma (LUAD), a prevalent form of non-small cell lung cancer (NSCLC), has a high incidence and mortality rate. However, its molecular...
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Polysaccharide-Based Drug Delivery Systems
Due to the incredible diversity of polysaccharides and their natural origin, these systems are essential because they can offer compatibility and...
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Insights into an NEk2 inhibitory profile of nitidine chloride by molecular docking and biological evaluation
Deregulation of NEK2(NIMA-related serine/threonine 2) confers chemotherapeutic resistance to apoptosis and is closely correlated with poor prognosis...
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Deregulation of miR-375 Inhibits HOXA5 and Promotes Migration, Invasion, and Cell Proliferation in Breast Cancer
Breast cancer (BC) is a highly aggressive tumour and one of the women’s leading causes of cancer-related deaths in worldwide. MiR-375 overexpressed...
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Targeting growth of breast cancer cell line (MCF-7) with curcumin-pyrimidine analogs
A series of curcumin-pyrimidine analogs ( 3a - 3h ) were synthesized with good yields using phase transfer catalysis. The antiproliferative activities of...
