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Small-molecule discovery through DNA-encoded libraries
The development of bioactive small molecules as probes or drug candidates requires discovery platforms that enable access to chemical diversity and...
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Artificial Intelligence Generative Chemistry Design of Target-Specific Scaffold-Focused Small Molecule Drug Libraries
The de novo design of scaffold-focused and target-specific molecular structures using deep learning generative modeling introduces a promising...
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The landscape of small-molecule prodrugs
Prodrugs are derivatives with superior properties compared with the parent active pharmaceutical ingredient (API), which undergo biotransformation...
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Biomarkers and Target-Specific Small-Molecule Drugs in Alzheimer’s Diagnostic and Therapeutic Research: From Amyloidosis to Tauopathy
Alzheimer’s disease (AD) is the most common type of human dementia and is responsible for over 60% of diagnosed dementia cases worldwide. Abnormal...
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Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal
Unprecedented efforts of the researchers have been witnessed in the recent past towards the development of vaccine platforms for the control of the...
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Recent Advances in Organic Small-Molecule Fluorescent Probes for the Detection of Zinc Ions (Zn2+)
Zinc(II) ions (Zn 2g ) play crucial roles in the growth, propagation, and metabolism of animals, plants, and humans. Abnormal concentrations of Zn 2+ in...
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Next-generation neuropeptide Y receptor small-molecule agonists inhibit mosquito-biting behavior
BackgroundFemale Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required for egg...
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MM165 - A Small Hybrid Molecule Modulates the Kynurenine Pathway and Attenuates Lipopolysaccharide-Induced Memory Deficits and Inflammation
Cognitive dysfunctions are now recognized as core symptoms of various psychiatric disorders e.g., major depressive disorder. Sustained immune...
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Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth
PurposeAberrant activation of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases drives oncogenic signaling through its...
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Designing Studies in Pharmaceutical and Medicinal Chemistry
The discovery of medicine started years ago with the use of medicinal plant parts for the benefit or improvement of physiological conditions. The...
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Peptidomimetics in Medicinal Chemistry: The Art of Transforming Peptides to Drugs
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or...
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The Genesis and Future Prospects of Small Molecule HIV-1 Attachment Inhibitors
Gp120 is a critical viral proteins required for HIV-1 entry and infection. It facilitates HIV-1 binding to target cells, human-to-human transmission,...
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Deep Learning and Computational Chemistry
Within the context of the latest resurgence in the application of artificial intelligence approaches, deep learning has undergone a renaissance over...
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Forensic Drug Chemistry: Unravelling Evidence Through Scientific Analysis
Forensic drug chemistry plays a pivotal role in modern criminal investigations by utilising scientific methods to identify, analyse, and interpret...
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Know your molecule: pharmacological characterization of drug candidates to enhance efficacy and reduce late-stage attrition
Despite advances in chemical, computational and biological sciences, the rate of attrition of drug candidates in clinical development is still high....
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Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects
RAS mutations prevalent in high-risk leukemia have been linked to relapse and chemotherapy resistance. Efforts to directly target RAS proteins have...
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Background to Chemistry of Small and Large Molecules
What are small and large drug molecules exactly? How do they physically interact with their protein targets to activate or inhibit them? How are...
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Small Molecule Screening Discovers Compounds that Reduce FMRpolyG Protein Aggregates and Splicing Defect Toxicity in Fragile X-Associated Tremor/Ataxia Syndrome
Expansion of CGG trinucleotide repeats in 5′ untranslated region of the FMR1 gene is the causative mutation of neurological diseases such as fragile...
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Molecule Ideation Using Matched Molecular Pairs
Matched Molecular Pair Analysis (MMP) is a very important tool during the lead optimization stage in drug discovery. The usefulness of this tool in...
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Recognition Units Built of Small Macrocyclic Molecules
The possibilities of organic chemistry to synthesize new molecules with increasing complexity and with more and more specialized functional behavior...