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Role of Block Copolymers in the Enhancement of Poor Solubility of Drugs
Low water solubility is the fundamental challenge in formulating both branded and generic formulations, which could result in insufficient absorption...
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Neural Network Models for Predicting Solubility and Metabolism Class of Drugs in the Biopharmaceutics Drug Disposition Classification System (BDDCS)
Background and ObjectiveThe biopharmaceutics drug disposition classification system (BDDCS) categorizes drugs into four classes on the basis of their...
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Soluplus® polymeric nanomicelles improve solubility of BCS-class II drugs
The issue of poor aqueous solubility is often a great hitch in the development of liquid dosage forms for those drugs that the Biopharmaceutics...
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Enhancing the Dissolution of Flutamide Through Supersaturation Using Beta-Cyclodextrin: a Promising Approach for Improved Solubility of Poorly Water-Soluble Drugs
PurposeThe study aims to explore the potential of amorphous solid dispersion (ASD) technology in improving the solubility and bioavailability of...
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Combination of co-crystal and nanocrystal techniques to improve the solubility and dissolution rate of poorly soluble drugs
PurposeSolubility and dissolution rate are essential for the oral absorption and bioavailability of poorly soluble drugs. The aim of this study was...
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Natural Products as Nano-Antidiabetic Drugs
Natural products have emerged as promising candidates for the development of nano-antidiabetic drugs, presenting a novel approach to combat the...
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Solubility Enhancement of Aripiprazole via Mesoporous Silica: Preparation, Characterization, In vitro Drug Release, and Solubility Determination
PurposeHollow types of mesoporous silica have been extensively used as drug delivery carriers owing to their excessive drug loading competence in the...
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Advanced Drug Delivery Strategies for Metal-Based Anticancer Drugs
Metal-based anticancer drugs, such as platinum complexes (e.g., cisplatin, carboplatin, and oxaliplatin), have demonstrated remarkable efficacy in...
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Comparative Drug Solubility Studies Using Shake-Flask Versus a Laser-Based Robotic Method
Drug solubility is of central importance to the pharmaceutical sciences, but reported values often show discrepancies. Various factors have been...
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Green Tea Catechins Decrease Solubility of Raloxifene In Vitro and Its Systemic Exposure in Mice
PurposeGreen tea is a widely consumed beverage. A recent clinical study reported green tea decreased systemic exposure of raloxifene and its...
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Enhancing the Stability, Solubility, and Antioxidant Activity of Cinchonine through Pharmaceutical Cocrystallization
PurposeCinchoninze hydrochloride solves the problem of the low solubility of cinchonine, but it is unstable and susceptible to deliquescence. In this...
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Solubility and Dissolution Enhancement of Luliconazole by a Cocrystal Engineering Technique with Different Coformers
IntroductionIn this article, we demonstrate the application of cooling crystallization to generate novel solid forms of drug-coformer cocrystal...
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Solid-State Techniques for Improving Solubility
Poor aqueous solubility of a drug substance can often be attributed to strong intermolecular forces within its crystal lattice, which, in turn,...
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Nanomedicines to Improve Oral Delivery of Antiretroviral Drugs
Over the years, oral drug delivery has been the route of choice for drug administration, and with no exception, the marketed antiretroviral...
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The Influence of Drugs Solubilities and Chitosan-TPP Formulation Parameters on the Mean Hydrodynamic Diameters and Drugs Entrapment Efficiencies into Chitosan-TPP Nanoparticles
Chitosan is a natural, biocompatible polymer. The aim of this work was to study the influence of drug solubility in 2% v/v acetic acid, formulation...
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Amorphization of Low Soluble Drug with Amino Acids to Improve Its Therapeutic Efficacy: a State-of-Art-Review
Low aqueous solubility of drug candidates is an ongoing challenge and pharmaceutical manufacturers pay close attention to amorphization (AMORP)...
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Importance of Considering Fed-State Gastrointestinal Physiology in Predicting the Reabsorption of Enterohepatic Circulation of Drugs
PurposeThe purpose of this study was to develop a simulation model for the pharmacokinetics (PK) of drugs undergoing enterohepatic circulation (EHC)...
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Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements
Lutein (Lut) is a recognized nutritional supplement known for its antioxidative and anti-inflammatory properties, crucial in mitigating ocular...
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A Potential Breakthrough in the Enhancement of Glimepiride Solubility and Dissolution Rate by Binary and Ternary Solid Dispersion Technique and In Vitro Comparison with Marketed Formulation
PurposeGlimepiride, an anti-diabetic and third-generation sulfonylurea drug belonging to class II BCS (Biopharmaceutical Classification System) type,...
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Clinical and Structural Highlights for Nanoparticle Formulations of Anticancer Drugs
Safety and efficacy are crucial to achieving clinical authorization to use anticancer drugs. Nevertheless, at the regulatory level, anticancer drugs...