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Associations of Polymorphisms in Leptin and Leptin Receptor Genes with Meat Quality in Pigs of the Ukrainian Large White Breed
AbstractThe associations of SNP in leptin gene ( LEP g.2845A>T, LEP g.3996T>C, LEP g.3469T>C) and leptin receptor gene ( LEPR c.232A>T, LEPR ...
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Obstructive Sleep Apnea in an Infant with Suspected Congenital Leptin Hormone Receptor Deficiency
An 8-month-old female child, born of a consanguineous marriage, presented to the Paediatrics department, with complaints of excessive weight gain,...
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Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport
BackgroundThe hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most...
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Serum Leptin as a Biomarker in Diabetes
Acromegaly is a rare disease caused by an overproduction of growth hormone and revealed by progressive clinical features. Due to the abundance of...
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Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages
BackgroundObesity-related asthma is a kind of nonallergic asthma with excessive neutrophil infiltration in the airways. However, the underlying...
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Circulating MiRNAs Are Associated With Low-grade Systemic Inflammation and Leptin Levels in Older Adults
Inflammaging refers to the low-grade systemic inflammation that occurs with aging present in chronic non-communicable diseases. MicroRNAs (miRNAs)...
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Association of Single Nucleotide Polymorphism LEP-R c.668A>G (p.Gln223Arg, rs1137101) of leptin receptor gene with endometrial cancer
BackgroundThe aim of this study was to analyze the frequencies of genotypes and alleles of Single Nucleotide Polymorphism (SNP) LEP-R c.668A>G ( p.Gln...
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Regulatory Basis of Adipokines Leptin and Adiponectin in Epilepsy: from Signaling Pathways to Glucose Metabolism
Epilepsy is a common and severe neurological disorder in which impaired glucose metabolism leads to changes in neuronal excitability that slow or...
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High Intensity Interval Training can Ameliorate Hypothalamic Appetite Regulation in Male Rats with Type 2 Diabetes: The Role of Leptin
Disruption of leptin (LEP) signaling in the hypothalamus caused by type 2 diabetes (T2D) can impair appetite regulation. The aim of this study was to...
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Serum Leptin as a Biomarker in Diabetes
Acromegaly is a rare disease caused by an overproduction of growth hormone and revealed by progressive clinical features. Due to the abundance of...
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Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors
BackgroundFetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood. Epigenetic alterations may be a mechanism in programming the...
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Hypolipidemic effect of ethanol extract from Chimonanthus nitens Oliv. leaves in hyperlipidemia rats via activation of the leptin/JAK2/STAT3 pathway
BackgroundThis study aims to explore the protective role of ethanol extract from Chimonanthus nitens Oliv. leaf (COE) in hyperlipidemia via the...
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Early adversity promotes binge-like eating habits by remodeling a leptin-responsive lateral hypothalamus–brainstem pathway
Early-life trauma (ELT) is a risk factor for binge eating and obesity later in life, yet the neural circuits that underlie this association have not...
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Aberrant miR-874-3p/leptin/EGFR/c-Myc signaling contributes to nasopharyngeal carcinoma pathogenesis
BackgroundLeptin is important in physiological and pathological functions in various cancers, however, the significance and mechanisms of leptin in...
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Effect of white tea consumption on serum leptin, TNF-α and UCP1 gene expression in ovariectomized rats
BackgroundObesity and dyslipidemia due to estrogen deficiency are among the important health problems in menopausal women. Increasing evidence...
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Association of gastric inhibitory polypeptide receptor (GIPR) gene polymorphism with type 2 diabetes mellitus in iranian patients
IntroductionGastric inhibitory polypeptide receptor (GIPR) encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was...
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Neuropeptide Y receptor Y8b (npy8br) regulates feeding and digestion in Japanese medaka (Oryzias latipes) larvae: evidence from gene knockout
Neuropeptide Y receptor Y8 (NPY8R) is a fish-specific receptor with two subtypes, NPY8AR and NPY8BR. Changes in expression levels during...
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Role of melatonin receptor 1B gene polymorphism and its effect on the regulation of glucose transport in gestational diabetes mellitus
Melatonin receptor 1B (MT2, encoded by the MTNR1B gene), a high-affinity receptor for melatonin, is associated with glucose homeostasis including...
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Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention
Diabetic kidney disease (DKD) is a major health burden closely related to lipid metabolism disorders. Leptin has lipid-lowering efficacy, but the...
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Immunolocalization of leptin and leptin receptor in colorectal mucosa of ulcerative colitis, Crohn’s disease and control subjects with no inflammatory bowel disease
The expression of leptin and leptin receptor (Ob-R) has been partially elucidated in colon of patients with inflammatory bowel diseases (IBDs), even...
