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Solubility Enhancement of Aripiprazole via Mesoporous Silica: Preparation, Characterization, In vitro Drug Release, and Solubility Determination
PurposeHollow types of mesoporous silica have been extensively used as drug delivery carriers owing to their excessive drug loading competence in the...
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Role of Block Copolymers in the Enhancement of Poor Solubility of Drugs
Low water solubility is the fundamental challenge in formulating both branded and generic formulations, which could result in insufficient absorption...
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Solid-State Techniques for Improving Solubility
Poor aqueous solubility of a drug substance can often be attributed to strong intermolecular forces within its crystal lattice, which, in turn,...
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Enhancing the Stability, Solubility, and Antioxidant Activity of Cinchonine through Pharmaceutical Cocrystallization
PurposeCinchoninze hydrochloride solves the problem of the low solubility of cinchonine, but it is unstable and susceptible to deliquescence. In this...
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Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements
Lutein (Lut) is a recognized nutritional supplement known for its antioxidative and anti-inflammatory properties, crucial in mitigating ocular...
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Comparative Drug Solubility Studies Using Shake-Flask Versus a Laser-Based Robotic Method
Drug solubility is of central importance to the pharmaceutical sciences, but reported values often show discrepancies. Various factors have been...
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Solubility vs Dissolution in Physiological Bicarbonate Buffer
BackgroundPhosphate buffer is often used as a replacement for the physiological bicarbonate buffer in pharmaceutical dissolution testing, although...
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Solubility and Dissolution Enhancement of Luliconazole by a Cocrystal Engineering Technique with Different Coformers
IntroductionIn this article, we demonstrate the application of cooling crystallization to generate novel solid forms of drug-coformer cocrystal...
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Green Tea Catechins Decrease Solubility of Raloxifene In Vitro and Its Systemic Exposure in Mice
PurposeGreen tea is a widely consumed beverage. A recent clinical study reported green tea decreased systemic exposure of raloxifene and its...
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Multivariate Analysis of Solubility Parameters for Drug-Polymer Miscibility Assessment in Preparing Raloxifene Hydrochloride Amorphous Solid Dispersions
The success of obtaining solid dispersions for solubility improvement invariably depends on the miscibility of the drug and polymeric carriers. This...
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Third Generation Solid Dispersion-Based Formulation of Novel Anti-Tubercular Agent Exhibited Improvement in Solubility, Dissolution and Biological Activity
The long treatment period and development of drug resistance in tuberculosis (TB) necessitates the discovery of new anti-tubercular agents. The drug...
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Nanofibers of Glycyrrhizin/Hydroxypropyl-β-Cyclodextrin Inclusion Complex: Enhanced Solubility Profile and Anti-inflammatory Effect of Glycyrrhizin
Despite having a wide range of therapeutic advantages, glycyrrhizin (GL) has few commercial applications due to its poor aqueous solubility. In this...
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Study on the Correlation Between Nimodipine (BCS Class II) Solubility, Dissolution Improvement, and Brain Tissue Concentration Through Cocrystallization
BackgroundCocrystallization by solvent evaporation was used to enhance the dissolution, physicochemical properties, and bioavailability of nimodipine...
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Co-Processed Crystalline Solids of Ivermectin with Span® 60 as Solubility Enhancers of Ivermectin in Natural Oils
Despite being discovered over five decades ago, little is still known about ivermectin. Ivermectin has several physico-chemical properties that can...
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Challenges and Strategies for Solubility Measurements and Dissolution Method Development for Amorphous Solid Dispersion Formulations
This manuscript represents the view of the Dissolution Working Group of the IQ Consortium on the challenges of and recommendations on solubility...
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Para-Hydroxy Benzoic Acid Coformer Enable Enhanced Solubility, Dissolution, and Antifungal Activity of Ketoconazole Cocrystals
PurposeThe present investigation was aimed at preparing ketoconazole cocrystals using phenolic acid coformers.
MethodThe slow solvent evaporation...
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Enhancing the Dissolution of Flutamide Through Supersaturation Using Beta-Cyclodextrin: a Promising Approach for Improved Solubility of Poorly Water-Soluble Drugs
PurposeThe study aims to explore the potential of amorphous solid dispersion (ASD) technology in improving the solubility and bioavailability of...
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Robust Wet Milling Technique for Producing Micronized Ibuprofen Particles with Improved Solubility and Dissolution
This study investigated a systematic approach for producing ibuprofen (IBF) particles with leucine by wet milling. Using a high shear homogenizer,...
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Enhancing Solubility and Dissolution Behavior of Finasteride Using Solid Dispersion Technique by Carrier Screening and the New Preparation Instrument
PurposeThe purpose of this study was to improve the solubility and dissolution rate of finasteride (FIN) by searching for an optimal carrier to...
