Definition
In understanding how a drug behaves once dosed to a body, a drug’s solubility in an aqueous media is a key parameter in controlling the subsequent in vivo levels [1]. Many solubility methods have been developed to provide in vitro solubility measurements. These methods expose a compound to a solvent for a period of time and then determine the concentration of the dissolved compound. For what is a relatively simple experiment to perform, there are numerous experimental factors that can affect a solubility measurement and, consequently, influence drug discovery decisions to varying extents.
The Importance of Solubility to a Drug
In the scenarios where a drug’s route of administration relies...
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Wenlock, M.C., Butler, P. (2022). Drug Solubility Assessment. In: Talevi, A. (eds) The ADME Encyclopedia. Springer, Cham. https://doi.org/10.1007/978-3-030-84860-6_143
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DOI: https://doi.org/10.1007/978-3-030-84860-6_143
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