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Pathophysiological functions of semaphorins in the sympathetic nervous system
Upon exposure to external stressors, the body senses them and activates the sympathetic nervous system (SNS) to maintain the homeostasis, which is...
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SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia
Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer...
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A pan-cancer study of class-3 semaphorins as therapeutic targets in cancer
BackgroundInitially characterized as axon guidance factors, semaphorins also have been implicated to have critical roles in multiple physiological...
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The emerging role of the semaphorin family in cartilage and osteoarthritis
In the pathogenesis of osteoarthritis, various signaling pathways may influence the bone joint through a common terminal pathway, thereby...
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Axon guidance molecules in immunometabolic diseases
The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic...
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Semaphorin 4B promotes tumor progression and associates with immune infiltrates in lung adenocarcinoma
BackgroundSemaphorins have been found to play important roles in multiple malignancy-related processes. However, the role of Semaphorin 4B (SEMA4B)...
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Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients
Focal cortical dysplasia (FCD) is a malformation of the cerebral cortex with poorly-defined epileptogenic zones (EZs), and poor surgical outcome in...
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Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by progressive memory decline and cognitive dysfunctions. Although the...
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Low Urine Secretion of Semaphorin3A in Lupus Patients with Proteinuria
Immune semaphorins are important in controlling both innate and adaptive immune responses. The regulatory role of semaphorin3A (sema3A) in systemic...
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LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms
Fibroblasts mediate tissue remodeling in eosinophilic esophagitis (EoE), a chronic allergen-driven inflammatory pathology. Diverse fibroblast...
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Semaphorin 3 C enhances putative cancer stemness and accelerates peritoneal dissemination in pancreatic cancer
PurposeSemaphorins, axon guidance cues in neuronal network formation, have been implicated in cancer progression. We previously identified semaphorin...
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Neuropilin-2 acts a critical determinant for epithelial-to-mesenchymal transition and aggressive behaviors of human head and neck cancer
PurposeNeuropilin-2 (NRP2) is a multifunctional single-pass transmembrane receptor that binds to two disparate ligands, namely, vascular endothelial...
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Neuroimmune semaphorins as costimulatory molecules and beyond
Several neuronal guidance proteins, known as semaphorin molecules, function in the immune system. This dual tissue performance has led to them being...
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Neural Crest
This chapter discusses the role of cardiac neural crest cells in the formation of the septum that divides the cardiac arterial pole into separate...
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Axonal Guidance: Making Connections
The vertebrate brain contains millions of neuronal and glial cells arranged in a highly organized manner forming functional neural circuits. To form...
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Loss-of-function variants in SEMA3F and PLXNA3 encoding semaphorin-3F and its receptor plexin-A3 respectively cause idiopathic hypogonadotropic hypogonadism
PurposeIdiopathic hypogonadotropic hypogonadism (IHH) is characterized by absent puberty and subsequent infertility due to gonadotropin-releasing...
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Regressive Phenomena: Refining Connections
Progressive events, such as the elaboration of axons and dendrites, create a template for the circuits that govern the many functions of our nervous...
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Proteome profile of nucleus accumbens (NAc) uncovers the differential and sex-specific role of CRMP2 in CVMS-induced mouse model of depression
Chronic stress plays a very important role in building pathogenesis of psychiatric disorders including major depressive disorder (MDD). Despite of...
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Molecular Pathways and Animal Models of Atrial Septal Defect
The relative simplicity of the clinical presentation and management of an atrial septal defect belies the complexity of the developmental...
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Total Anomalous Pulmonary Venous Connections, Human Genetics
Partial anomalous pulmonary venous connections (PAVC) have been found after abnormal gene expressions involving several syndromes. Total anomalous...