Search
Search Results
-
Reinforcement Motor Learning After Cerebellar Damage Is Related to State Estimation
Recent work showed that individuals with cerebellar degeneration could leverage intact reinforcement learning (RL) to alter their movement. However,...
-
Operant novelty seeking predicts cue-induced reinstatement following cocaine but not water reinforcement in male rats
RationaleAn important facet of cocaine addiction is a high propensity to relapse, with increasing research investigating factors that predispose...
-
The secondary visual cortex mediated the enhancement of associative learning on methamphetamine self-administration behaviors
RationaleMethamphetamine addiction is a persistent and intractable pathological learning and memory, whereas no approved therapeutics is available....
-
Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement
RationaleNicotine dependence is highly comorbid with opioid use disorders (OUDs). The use of nicotine-containing products increases the propensity to...
-
Involvement of Midbrain Dopamine Neuron Activity in Negative Reinforcement Learning in Mice
The activity of the midbrain dopamine system reflects the valence of environmental events and modulates various brain structures to modify an...
-
Repetitive transcranial magnetic stimulation (rTMS) as a tool for cognitive enhancement in healthy adults: a review study
As human beings, we have always sought to expand on our abilities, including our cognitive and motor skills. One of the still-underrated tools...
-
Single Exposure to Cocaine Impairs Reinforcement Learning by Potentiating the Activity of Neurons in the Direct Striatal Pathway in Mice
Plasticity in the glutamatergic synapses on striatal medium spiny neurons (MSNs) is not only essential for behavioral adaptation but also extremely...
-
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Many social behaviours are evolutionarily conserved and are essential for the healthy development of an individual. The neuropeptide oxytocin (OXT)...
-
Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria
The breakdown of the gut’s mucosal barrier that prevents the infiltration of microorganisms, inflammatory cytokines and toxins into bodily tissues...
-
Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri
Nadia Chaudhri worked with us as a graduate student in the Center for Neuroscience at the University of Pittsburgh from 1999 until she earned her PhD...
-
Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects
Rationale and objectivesThe reinforcement-enhancing effect (REE) of nicotine refers to the drug’s ability to enhance the strength of other primary...
-
Biomechanical Effect of Using Cement Augmentation to Prevent Proximal Junctional Kyphosis in Long-Segment Fusion: A Finite Element Study
PurposeThe purpose of this study was to compare the biomechanical effects of cement-reinforced vertebrae at different levels and with different...
-
Vision Augmentation by Pharmacological Enhancement of the Visual Experience
Cortical plasticity, attention, and learning lead to perceptual learning and might robustly enhance sensory perception in rodents and humans. Central...
-
Depressive symptoms bias the prediction-error enhancement of memory towards negative events in reinforcement learning
RationaleDepression is a disorder characterized by sustained negative affect and blunted positive affect, suggesting potential abnormalities in...
-
The Rate-Correlation Theory of Goal-Directed Behavior: An Update
Over half a century ago, Baum (J Exp Anal Behav 20:137–153, 1973) proposed a theory based on the idea that behavior should be analyzed in terms of...
-
Effects of isoflurane anesthesia on addictive behaviors in rats
RationaleRecently, it has been suggested that isoflurane might reduce dopamine release from rat midbrain dopaminergic neurons, the neurobiological...
-
Dynamical systems model of development of the action differentiation in early infancy: a requisite of physical agency
Young infants are sensitive to whether their body movements cause subsequent events or not during the interaction with the environment. This ability...
-
Transcranial Direct Current Electrical Stimulation Modulates the Feedback-Related Negativity Component in a Monetary Game
The present study addressed the neurophysiological effects of transcranial direct current stimulation (tDCS) on a component of evoked potentials...
-
Blockade of the Dopamine D3 Receptor Attenuates Opioids-Induced Addictive Behaviours Associated with Inhibiting the Mesolimbic Dopamine System
Opioid use disorder (OUD) has become a considerable global public health challenge; however, potential medications for the management of OUD that are...
-
Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma
ObjectiveThe aim of this study was to investigate the clinical, imaging and pathological features of extraskeletal osteosarcoma (EOS) and to improve...
