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Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri

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Abstract

Nadia Chaudhri worked with us as a graduate student in the Center for Neuroscience at the University of Pittsburgh from 1999 until she earned her PhD in 2005, a time that coincided with the discovery in our lab of the dual reinforcing actions of nicotine, a concept that she played an important role in sha**. The research that was described in her doctoral thesis is among the foundational pillars of the now well-accepted notion that nicotine acts as both a primary reinforcer and an amplifier of other reinforcer stimuli. This reinforcement-enhancing action of nicotine is robust and likely to be a powerful driver of nicotine use. Below, we discuss the evidence that these two actions of nicotine — primary reinforcement and reinforcement enhancement — are distinct and dissociable, a finding that Nadia was closely associated with. We go on to address two other topics that greatly interested Nadia during that time, the generalizability of the reinforcement-enhancing action of nicotine to multiple classes of reinforcing stimuli and potential sex differences in the dual reinforcing actions of nicotine. The research has greatly expanded since Nadia’s involvement, but the core ideas that she helped to develop remain central to the concept of the dual reinforcing actions of nicotine and its importance for understanding the drivers of nicotine use.

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  1. Departments of Neuroscience, Psychiatry and Psychology and the Center for Neuroscience, University of Pittsburgh, 210 Langley Hall, Pittsburgh, PA, 15260, USA

    Alan F. Sved

  2. Departments of Psychology and Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15260, USA

    Anthony R. Caggiula

  3. Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA

    Eric C. Donny

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Sved, A.F., Caggiula, A.R. & Donny, E.C. Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri. Psychopharmacology 240, 417–430 (2023). https://doi.org/10.1007/s00213-022-06266-7

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