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Chromatin Immunoprecipitation Sequencing (ChIP-Seq) Assay in Food Allergy Research
Chromatin immunoprecipitation (ChIP) analysis followed by genome-wide sequencing represents the most efficient method for studying the complex...
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Develop quantitative FRET (qFRET) technology as a high-throughput universal assay platform for basic quantitative biomedical and translational research and development
Protein–protein interactions and enzyme-catalyzed reactions are the fundamental processes in life, and the quantification and manipulation, kinetics...
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Chromatin Immunoprecipitation Assay in Mouse Retinal Tissue
Chromatin immunoprecipitation (ChIP) is one of the most widely used methods for investigating interactions between proteins and DNA sequences. ChIP...
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Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue
The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining...
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Engineered extracellular vesicle-encapsulated CHIP as novel nanotherapeutics for treatment of renal fibrosis
Renal interstitial fibrosis (RIF) is a fundamental pathological feature of chronic kidney disease (CKD). However, toxicity and poor renal enrichment...
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Vascularized organoid-on-a-chip: design, imaging, and analysis
Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more physiologically relevant...
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CHIP promotes CAD ubiquitination and degradation to suppress the proliferation and colony formation of glioblastoma cells
PurposeCancer cells are characterized as the uncontrolled proliferation, which demands high levels of nucleotides that are building blocks for DNA...
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The Chromatin Immunoprecipitation (ChIP) Protocol for African Turquoise Killifish
DNA-binding proteins and epigenetic modifications coordinate to regulate the spatiotemporal pattern of gene expression during development, and thus,...
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Integrative analyses of RNA-seq and ChIP-seq Reveal MITF as a Target Gene of TFPI-2 in MDA231 Cells
Breast cancer is the most prevalent cance
r in female patients worldwide. Tissue factor pathway inhibitor 2 (TFPI-2) is identified as an important...
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Microfluidics-on-a-chip for designing celecoxib-based amorphous solid dispersions: when the process shapes the product
The fundamental idea underlying the use of amorphous solid dispersions (ASDs) is to make the most of the solubility advantage of the amorphous form...
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Skin-on-Chip
In the last few decades, skin bioengineering has undergone several advancements. The need, understanding, and importance of develo** artificial...
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A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications
A crucial step in lead selection during drug development is accurate estimation and optimization of hepatic clearance using in vitro methods....
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Validation Procedures for Quantification of Food Allergens by Enzyme-Linked Immunosorbent Assay (ELISA)
Enzyme-linked immunosorbent assay (ELISA) is a widely used analytical technique for food allergen detection and quantification. Validating ELISA...
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Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants
Mutations in the TP53 tumor suppressor gene occur in >80% of the triple-negative or basal-like breast cancer. To test whether neomorphic functions of...
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Digital Quantification of Human Viral RNA and DNA Using a Self-Digitization Chip
Digital nucleic acid quantitation methods show excellent sensitivity and specificity for pathogen detection. Droplet digital PCR (ddPCR) is the most...
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A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma
Rapid, accurate and frequent detection of the RNA of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and of serological host antibodies...
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Tumor-on-a-Chip: Microfluidic Models of Hypoxic Tumor Microenvironment
Cancer is ranked as the deadliest prime health issue, albeit with mammoth efforts to panacea the ailment. To subdue the vast constraints in tumor...
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RepEnTools: an automated repeat enrichment analysis package for ChIP-seq data reveals hUHRF1 Tandem-Tudor domain enrichment in young repeats
BackgroundRepeat elements (REs) play important roles for cell function in health and disease. However, RE enrichment analysis in short-read...
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A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity
The development of inhaled drugs for respiratory diseases is frequently impacted by lung pathology in non-clinical safety studies. To enable design...
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Proximity Extension Assay (PEA) Platform to Detect Vitreous Biomarkers of Diabetic Retinopathy
Diabetic retinopathy (DR) is one of the leading causes of blindness, affecting more than 100 million people worldwide. Currently, DR prognosis and...