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High-Resolution Mass Spectrometry in NPS Analysis
The gold standard for the new psychoactive substance (NPS)New psychoactive substance (NPS) detection in toxicology is high-resolution mass...
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Mass Spectrometry-Based Vitreous Proteomics: Validated Methods and Analysis Pipeline
Retinal diseases like diabetic retinopathy and age-related macular degeneration affect millions of individuals worldwide and often lead to vision...
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Mass Spectrometry-Based Metabolomics Multi-platform for Alzheimer’s Disease Research
The integration of complementary analytical platforms is nowadays the most common strategy for comprehensive metabolomics analysis of complex...
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Mass Spectrometry for the Advancement of Lipid Analysis in Alzheimer’s Research
Recent technical advances in mass spectrometry, as applied to the analytical chemistry of lipid molecules, enable the simultaneous detection of the...
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Mass Spectrometry Analysis of the Human Brain Sphingolipidome
In recent decades, mass spectrometry-based lipidomics has provided a fertile environment for scientific investigations of biochemical and mechanistic...
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Urinary Profiling with Liquid Chromatography-Mass Spectrometry
Prediabetes is a metabolic syndrome characterized by an elevated blood sugar. About 5–10% of prediabetes developed into diabetes. Prediabetes usually...
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Mass Spectrometry-Based Proteomics Analysis Unveils PTPRS Inhibits Proliferation and Inflammatory Response of Keratinocytes in Psoriasis
In this study, we used data-independent acquisition-mass spectrometry (DIA-MS) to analyze the serum proteome in psoriasis vulgaris (PsO). The serum...
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Progress in mass spectrometry approaches to profiling protein–protein interactions in the studies of the innate immune system
Understanding protein–protein interactions (PPIs) is pivotal for deciphering the intricacies of biological processes. Dysregulation of PPIs underlies...
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Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology
BackgroundAntibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in...
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Biophysical Characterization of RAS-SOS Complexes by Native Mass Spectrometry
RAS is regulated by specific guanine nucleotide exchange factors, such as Son of Sevenless (SOS), that activates RAS by facilitating the exchange of...
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Mass Spectrometry-Based Tissue Imaging of the Tumor Microenvironment
Multiplex ion beam imaging (MIBI) and imaging mass cytometry (IMC) enable highly multiplexed antibody (40+) staining of frozen or formalin fixed,...
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Mass Spectrometry Multiplexed Detection of SARS-CoV-2
Testing of large populations for virus infection is now a reality worldwide due to the coronavirus (SARS-CoV-2) pandemic. The demand for SARS-CoV-2...
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Mass spectrometry-based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta-analysis of individual patient data
BackgroundThe cerebrospinal fluid (CSF) proteome could offer important insights into central nervous system (CNS) malignancies. To advance proteomic...
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Analysis of Carbohydrates by Mass Spectrometry
Mass spectrometry has become the favorite technique for glycomics analysis. This chapter describes the different ionization methods and provides...
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Salivary Proteomic Analysis of Canine Oral Melanoma by MALDI-TOF Mass Spectrometry and LC-Mass Spectrometry/Mass Spectrometry
Canine oral melanoma (COM) is a common oral cancer with aggressiveness and high metastasis. A tumor in a dog’s mouth makes it difficult to be...
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Isolation and Mass Spectrometry-Based Profiling of Major Lipids in Brown Adipose Tissue
Brown adipose tissue (BAT) is an important regulator of metabolic homeostasis through its role in adaptive thermogenesis and control of whole-body...
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High-Resolution Mass Spectrometry in Identification of New Analytes & Metabolites
Numerous forensic institutes including the National Board of Forensic Medicine in Sweden have been using high-resolution mass spectrometry to...
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Identification of the protein coding capability of coronavirus defective viral genomes by mass spectrometry
During coronavirus infection, in addition to the well-known coronavirus genomes and subgenomic mRNAs, an abundance of defective viral genomes (DVGs)...
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MALDI-TOF Mass Spectrometry-Based Assay for Measuring Covalent Target Engagement of KRAS G12C Inhibitors
MALDI-TOF mass spectrometry enables high-throughput screening of covalent fragment libraries and SAR compound progressions of selective KRAS G12C...