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Ibuprofen, other NSAIDs and COVID-19: a narrative review
At the start of the coronavirus disease 2019 (COVID-19) pandemic (March 2020), there was speculation that non-steroidal anti-inflammatory drugs...
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Fluconazole-Loaded Ibuprofen In Situ Gel-Based Oral Spray for Oropharyngeal Candidiasis Treatment
Oral candidiasis is a fungal infection affecting the oral mucous membrane, and this research specifically addresses on a localized treatment through...
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Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis
Pyroptosis is a novel type of proinflammatory programmed cell death that is associated with inflammation, immunity, and cancer. Anaplastic thyroid...
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Analgesic effect of oral paracetamol 1000 mg/ibuprofen 400 mg, paracetamol 1000 mg/codeine 60 mg, paracetamol 1000 mg/ibuprofen 400 mg/codeine 60 mg, or placebo on acute postoperative pain: a single-dose, randomized, and double-blind study
PurposeCombining analgesics with different mechanisms of action may increase the analgesic efficacy. The multidimensional pharmacodynamic profiles of...
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Development of Delayed-Release Pellets of Ibuprofen Using Kollicoat® MAE 100P via Hot-Melt Extrusion Technology
PurposeThe present work was intended to develop the ibuprofen-Kollicoat ® MAE 100P delayed-release pellets using hot-melt extrusion technology, which...
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Comparative study of the effects of ibuprofen, acetaminophen, and codeine in a model of orofacial postoperative pain in male and female rats
Pain management is a primary goal after oral surgeries, but little is known about sex differences in the sensitivity to analgesics. This study aimed...
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Homocysteine May Decrease Glucose Uptake and Alter the Akt/GSK3β/GLUT1 Signaling Pathway in Hippocampal Slices: Neuroprotective Effects of Rivastigmine and Ibuprofen
Homocysteine (Hcy) is a risk factor for neurodegenerative diseases, such as Alzheimer’s Disease, and is related to cellular and tissue damage. In the...
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Acute ingestion of Ibuprofen does not influence the release of IL-6 or improve self-paced exercise in the heat despite altering cortical activity
The present study tested the hypothesis that ingesting 800 mg Ibuprofen prior to self-paced cycling at a fixed rating of perceived exertion (RPE)...
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Ultrasound-Assisted Anti-Solvent Crystallization of Ibuprofen: Effect of Ultrasonic Treatment and Additive
PurposeThis study aims to determine the effect of ultrasonic treatment and additive on the morphology, physicochemical properties, and dissolution of...
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Inclusion Complex of Ibuprofen-β-Cyclodextrin Incorporated in Gel for Mucosal Delivery: Optimization Using an Experimental Design
β-Cyclodextrin/ibuprofen inclusion complex was synthesized by freeze-drying method and characterized for phase solubility profiles, infrared spectra,...
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Acute administration of ibuprofen increases serum concentration of the neuroprotective kynurenine pathway metabolite, kynurenic acid: a pilot randomized, placebo-controlled, crossover study
RationaleAt least six different types of antidepressant treatments have been shown to either increase the neuroprotective kynurenine pathway (KP)...
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The effects of Ibuprofen and 1, 8- cineol on anxiety and spatial memory in hyperammonemic rats
In hepatic encephalopathy, hyperammonemia (HA) causes cognitive impairment and anxiety by causing neuroinflammation. Ibuprofen and 1,8- cineol have...
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Synthesis, theoretical investigations and biological evaluation of ibuprofen drug hybrids
In the present work, four Ibuprofen drug hybrids ( 1 – 4 ) were designed by modifying free amino groups of 4-aminoantipyrine, sulfamethoxazole,...
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Green Constant-wavelength Concurrent Selective Fluorescence Method for Assay of Ibuprofen and Chlorzoxazone in Presence of Chlorzoxazone Degradation Product
Lower back pain is a universal dilemma leaving a negative effect on both health and life quality. It was found that a fixed dose combination of...
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Evaluation of Emulgel and Nanostructured Lipid Carrier-Based Gel Formulations for Transdermal Administration of Ibuprofen: Characterization, Mechanical Properties, and Ex-Vivo Skin Permeation
In transdermal applications of nonsteroidal anti-inflammatory drugs, the rheological and mechanical properties of the dosage form affect the...
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Trichopus zeylanicus ameliorates ibuprofen inebriated hepatotoxicity and enteropathy: an insight into its modulatory impact on pro/anti-inflammatory cytokines and apoptotic signaling pathways
Ibuprofen is a nonsteroidal anti-inflammatory drug that is commonly used for its analgesic, antipyretic and anti-inflammatory effects worldwide....
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Robust Wet Milling Technique for Producing Micronized Ibuprofen Particles with Improved Solubility and Dissolution
This study investigated a systematic approach for producing ibuprofen (IBF) particles with leucine by wet milling. Using a high shear homogenizer,...
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Novel cytotoxicity study of strontium (Sr) doped iron oxide (Fe3O4) nanoparticles aided with ibuprofen for drug delivery applications
This work is aimed at studying the drug delivery applications of iron oxide (Fe 3 O 4 ) nanoparticles with strontium (Sr) do** with varying molar...
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Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers
Background and ObjectiveCombined acetaminophen and ibuprofen are common antipyretic and analgesic drugs. Formulation and feeding affect drug...
