A nonsteroidal anti-inflammatory drug (NSAID) is ibuprofen. It lowers hormones that lead to pain and inflammation in the body. Ibuprofen is commonly prescribed as an analgesic, antipyretic, and anti-inflammatory drug for several extremely painful musculoskeletal illnesses, including osteoarthritis and others. Ibuprofen’s medicinal actions are caused by reversible binding to COX receptors on prostaglandin synthase, commonly known as cyclooxygenase (COX), which blocks arachidonic acid from attaching to these sites. This stops arachidonic acid from being transformed into the numerous prostaglandins that are responsible for the inflammation like pain (dolor), swelling (tumor), heat (calor), and redness (rubor). The analgesic action of ibuprofen and other NSAIDs is caused by prostaglandins, which also contribute to the sensitization of pain-sensing nerve fibers. To reduce fever, ibuprofen also affects the hypothalamic thermoregulatory area. Prostaglandins have crucial functions in many...
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(2024). Ibuprofen. In: Dictionary of Toxicology. Springer, Singapore. https://doi.org/10.1007/978-981-99-9283-6_1299
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DOI: https://doi.org/10.1007/978-981-99-9283-6_1299
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