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High-Resolution Mass Spectrometry in NPS Analysis
The gold standard for the new psychoactive substance (NPS)New psychoactive substance (NPS) detection in toxicology is high-resolution mass...
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High-Resolution Mass Spectrometry in Identification of New Analytes & Metabolites
Numerous forensic institutes including the National Board of Forensic Medicine in Sweden have been using high-resolution mass spectrometry to...
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A Spike-Control Approach that Evaluates High Resolution Mass Spectrometry-Based Sequence Variant Analytical Method Performance for Therapeutic Proteins
An amino acid sequence variant (SV) is defined as an unintended amino acid substitution in protein drug products. SVs contribute to product...
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Elucidating hippocampal proteome dynamics in moderate hepatic encephalopathy rats: insights from high-resolution mass spectrometry
Hepatic encephalopathy (HE) is a debilitating neurological disorder associated with liver failure and characterized by impaired brain function....
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Mass Spectrometry-Based Metabolomics Multi-platform for Alzheimer’s Disease Research
The integration of complementary analytical platforms is nowadays the most common strategy for comprehensive metabolomics analysis of complex...
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Ultra-performance liquid chromatography coupled with quadrupole high-resolution time-of-flight mass spectrometry for metabolite profiling and biological activity of Stellaria pallida (Dumort) Piré
Medicinal plants have a wide variety of valuable biological activities. Stellaria pallida (Dumort) Piré is a well-known plant; however, this species’...
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Mass Spectrometry for the Advancement of Lipid Analysis in Alzheimer’s Research
Recent technical advances in mass spectrometry, as applied to the analytical chemistry of lipid molecules, enable the simultaneous detection of the...
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Flow Infusion ESI High Resolution Mass Spectrometry Metabolomics Analytical Platforms
Flow infusion ESI high resolution (0.4–3 ppm mass error) mass spectrometric metabolomics allows for the analysis of a broad array of metabolites of...
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High-Resolution Imaging Mass Spectrometry of Human Donor Eye: Photoreceptors Cells and Basal Laminar Deposit of Age-Related Macular Degeneration
Pathologies of the retina are clinically visualized in vivo with OCT and ex vivo with immunohistochemistry. Although both techniques provide valuable...
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Mass Spectrometry-Based Vitreous Proteomics: Validated Methods and Analysis Pipeline
Retinal diseases like diabetic retinopathy and age-related macular degeneration affect millions of individuals worldwide and often lead to vision...
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Biophysical Characterization of RAS-SOS Complexes by Native Mass Spectrometry
RAS is regulated by specific guanine nucleotide exchange factors, such as Son of Sevenless (SOS), that activates RAS by facilitating the exchange of...
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Highly stable peptide adducts from hard keratins as biomarkers to verify local sulfur mustard exposure of hair by high-resolution mass spectrometry
In the recent past, the blister agent sulfur mustard (SM) deployed by the terroristic group Islamic State has caused a huge number of civilian and...
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Mass Spectrometry-Based Tissue Imaging of the Tumor Microenvironment
Multiplex ion beam imaging (MIBI) and imaging mass cytometry (IMC) enable highly multiplexed antibody (40+) staining of frozen or formalin fixed,...
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MALDI-TOF Mass Spectrometry-Based Assay for Measuring Covalent Target Engagement of KRAS G12C Inhibitors
MALDI-TOF mass spectrometry enables high-throughput screening of covalent fragment libraries and SAR compound progressions of selective KRAS G12C...
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Progress in mass spectrometry approaches to profiling protein–protein interactions in the studies of the innate immune system
Understanding protein–protein interactions (PPIs) is pivotal for deciphering the intricacies of biological processes. Dysregulation of PPIs underlies...
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Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology
BackgroundAntibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in...
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Automated Multidimensional Nanoscale Chromatography for Ultrasensitive Targeted Mass Spectrometry
Recent advances in nanoscale separations and high-resolution mass spectrometry permit highly sensitive and accurate analyses of complex protein...
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Spatial visualization of drug uptake and distribution in Fasciola hepatica using high-resolution AP-SMALDI mass spectrometry imaging
Understanding drug penetration, distribution, and metabolization is fundamental for understanding drug efficacy. This also accounts for parasites...
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Mass Spectrometry Multiplexed Detection of SARS-CoV-2
Testing of large populations for virus infection is now a reality worldwide due to the coronavirus (SARS-CoV-2) pandemic. The demand for SARS-CoV-2...
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Falsified and problematic methandienone products available online: active pharmaceutical ingredient identification by portable Raman spectrometers and quantification by ultra-high-performance liquid chromatography–Fourier transform mass spectrometry
This study aimed on the one hand to clarify the quality, authenticity, safety, and other issues related to products of the anabolic-androgenic...
